公开(公告)号：US20120028359A1

公开(公告)日：2012-02-02

申请号：US13263182

申请日：2010-04-06

申请人： In Ho Choi ,  Dong Mok Lee ,  Jong Soo Chang ,  Hyun Jeong Lee ,  Eun Ju Lee ,  Bajracharya Prati ,  Yu Mi Shin

发明人： In Ho Choi ,  Dong Mok Lee ,  Jong Soo Chang ,  Hyun Jeong Lee ,  Eun Ju Lee ,  Bajracharya Prati ,  Yu Mi Shin

IPC分类号： G01N33/12 ,  C07C57/03 ,  C07H21/02 ,  C07C53/00 ,  G01N33/92 ,  C07K16/18

CPC分类号： G01N33/92 ,  C12Q1/6883 ,  C12Q1/6888 ,  C12Q2600/124 ,  G01N33/743 ,  G01N2800/044

摘要： The present invention relates to a production process of a gender-specific serum and a biomarker using the serum. More specifically, the present invention uses a fatty acid that exhibits a specific expression pattern in a gender-specific serum as a biomarker not only for diagnosis of obesity or a disease related to obesity, but also for diagnosis of meat quality since the fatty acid promotes differentiation of muscle derived stem cells into adipose cells. In addition, the present invention can establish a research system studying the effects of steroid hormones on the cell culture by using sera separated from blood that is collected from individual mammal carcasses being disposed, and provide important clues for discovering a gene associated with the synthesis of steroid hormone and for developing treatments for human diseases. Further, the present invention may contribute to increased profits derived from producing high quality sera, a reduced cost with treatment for carcass wastes, and promotion of the eco-industry for reducing environmental hormones.

摘要翻译： 本发明涉及使用血清的性别特异性血清和生物标志物的制备方法。 更具体地，本发明使用在性别特异性血清中表现出特异性表达模式的脂肪酸作为生物标志物，不仅用于诊断肥胖症或与肥胖有关的疾病，而且还用于肉质量的诊断，因为脂肪酸促进 将肌肉干细胞分化为脂肪细胞。 此外，本发明可以建立研究系统，通过使用从被处置的各个哺乳动物尸体收集的血液分离的血清，研究类固醇激素对细胞培养物的作用，并提供发现与合成相关的基因的重要线索 类固醇激素和用于开发人类疾病的治疗。 此外，本发明可以有助于生产高质量血清的利润增加，屠体废物处理成本降低，促进生态工业减少环境激素。