公开(公告)号：US20190055601A1

公开(公告)日：2019-02-21

申请号：US16110989

申请日：2018-08-23

申请人： CY O'Connor ERADE Village Foundation

发明人： Roger Letts Dawkins ,  John Anthony Millman ,  Joseph Frederick Williamson ,  Patrick Robert Carnegie

IPC分类号： C12Q1/6876 ,  C12Q1/6883

CPC分类号： C12Q1/6876 ,  C12Q1/6883 ,  C12Q2600/124 ,  C12Q2600/156 ,  C12Q2600/172

摘要： The present invention relates to methods of genotyping for selecting an animal with a desired trait such as the level monounsaturated fats in muscle tissue, the types and/or ratio of different monounsaturated fats in muscle tissue, marbling, carcass weight, meat quality, speed of finishing, feedlot efficiency and/or consumer preference. In particular the invention relates to methods of selecting an animal with a desired trait by analysing the M-RIP, NT5M and/or TCAP genes for one or more polymorphisms.

公开(公告)号：US20190051418A1

公开(公告)日：2019-02-14

申请号：US16167463

申请日：2018-10-22

申请人： The Translational Genomics Research Institute ,  University of Georgia Research Foundation, Inc.

发明人： Matthew Huentelman ,  Scott Schatzberg ,  Renee Barber

IPC分类号： G16H50/30 ,  C12Q1/6883 ,  A01K67/02

CPC分类号： G16H50/30 ,  A01K67/02 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/118 ,  C12Q2600/124 ,  C12Q2600/156 ,  C12Q2600/172

摘要： The present invention provides method of classifying a subject into a necrotizing meningoencephalitis (NME) disease risk group. The method may include assessing the presence of one or more marker (e.g., SNPs or risk loci) in a sample from the subject. For example, detection of the presence of one or more markers that are associated with an increased risk of NME can indicate that the subject should be classified into a risk group.

公开(公告)号：US10000811B2

公开(公告)日：2018-06-19

申请号：US14896736

申请日：2014-06-25

申请人： Elanco US Inc. ,  McGill University

发明人： Roger K. Prichard ,  Catherine Bourguinat ,  Timothy G. Geary

IPC分类号： C07H21/04 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6888 ,  C12Q2600/124 ,  C12Q2600/136 ,  C12Q2600/156

摘要： Disclosed are nucleic acid molecules from the genome of Dirofilaria spp. nematodes that contain single nucleotide polymorphisms related to reduced responsiveness of the nematodes to macrocyclic lactones. In one example, the species of Dirofilaria is Dirofilaria immitis (the agent of heartworm in animals). Also disclosed are methods for determining the responsiveness of Dirofilaria spp. nematodes to macrocyclic lactones, methods for selecting a treatment to treat an animal infected with a Dirofilaria spp. nematode, and kits for determining the responsiveness of Dirofilaria spp. nematodes to macrocyclic lactones.

公开(公告)号：US09994904B2

公开(公告)日：2018-06-12

申请号：US15011830

申请日：2016-02-01

申请人： Robert Philibert ,  Anup Madan

发明人： Robert Philibert ,  Anup Madan

IPC分类号： C07H21/02 ,  G01N33/44 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6869 ,  C12Q2600/112 ,  C12Q2600/124 ,  C12Q2600/154 ,  Y10T436/143333 ,  C12Q2523/125

摘要： The present invention provides screening kits, compositions, and diagnostic methods for determining whether a subject has a predisposition to, or likelihood of having, a substance use disorder by determining a nucleic acid methylation profile from a biological sample from the subject, wherein a given profile indicates that the subject has a predisposition to a substance use disorder.

公开(公告)号：US20180142295A1

公开(公告)日：2018-05-24

申请号：US15865225

申请日：2018-01-08

申请人： Xiangyang MIAO

发明人： Xiangyang MIAO

IPC分类号： C12Q1/6876 ,  C12N15/113

CPC分类号： C12Q1/6876 ,  C12N15/113 ,  C12N2310/141 ,  C12Q2600/124 ,  C12Q2600/158 ,  C12Q2600/178

摘要： A kit for real-time fluorescence quantitative PCR adapted to detect an expression level of a miRNA-4749-5 having a sequence of SEQ ID NO: 1 is disclosed. The kit includes a specific primer consisting of SEQ ID NO: 5 or a primer pair consisting of SEQ ID NO: 3 and SEQ ID NO: 4.

公开(公告)号：US09856531B2

公开(公告)日：2018-01-02

申请号：US14990810

申请日：2016-01-08

申请人： WISCONSIN ALUMNI RESEARCH FOUNDATION

发明人： Hasan Khatib

IPC分类号： A61D19/02 ,  A61D19/04 ,  C12Q1/68 ,  C12P19/34 ,  C07H21/04

CPC分类号： C12Q1/6876 ,  A61D19/02 ,  A61D19/04 ,  C07H21/04 ,  C12Q1/6888 ,  C12Q2600/124 ,  C12Q2600/156 ,  C12Q2600/172

摘要： An isolated nucleic acid molecule comprising a polymorphic site selected from the group consisting of positions 164, 269, 284, 407 and 989 of SEQ ID NO: 1, an array or a kit comprising the same. Also provided are a method for detecting single nucleotide polymorphism (SNP) in bovine proteinase inhibitor (PI) gene, a method for haplotyping a bovine cell, a method for progeny testing of cattle based on said haplotyping, a method for selectively breeding of cattle based on haplotyping a parent animal. The present invention further provides a method for testing a dairy cattle for its milk production trait, comprising haplotyping its cells, wherein a cattle having haplotypes 1, 3, 4 or 5 indicates that the cattle has desirable milk production trait. Haplotype 1 indicates that the cattle has the most desirable milk production trait.

公开(公告)号：US20170363615A1

公开(公告)日：2017-12-21

申请号：US15613312

申请日：2017-06-05

申请人： SENOMYX, INC.

发明人： Mark ZOLLER ,  Xiaodong LI ,  Lena Staszewski ,  Shawn O'Connell ,  Sergey Zozulya ,  Jon Elliot Adler ,  Hong Xu ,  Fernando Echeverri

IPC分类号： G01N33/50 ,  C12Q1/68 ,  G01N33/566 ,  C07K14/705

CPC分类号： G01N33/5041 ,  A01K2217/05 ,  C07K14/705 ,  C07K2319/00 ,  C12Q1/6876 ,  C12Q2600/124 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/566 ,  G01N2333/4719 ,  G01N2333/705 ,  G01N2333/726 ,  G01N2500/04

摘要： The present invention relates to the discovery that the T1R receptors assemble to form functional taste receptors. Particularly, it has been discovered that co-expression of T1R1 and T1R3 results in a taste receptor that responds to umami taste stimuli, including monosodium glutamate. Also, it has been discovered that co-expression of the T1 R2 and T1R3 receptors results in a taste receptor that responds to sweet taste stimuli including naturally occurring and artificial sweeteners.Also the present invention relates to the use of hetero-oligomeric taste receptors comprising T1R1/T1R3 and T1R2/T1R3 in assays to identify compounds that respectively respond to umami taste stimuli and sweet taste stimuli.Further, the invention relates to the constitutive of cell lines that stably or transiently co-express a combination of T1R1 and T1R3; or T1R2 and T1R3; under constitutive or inducible conditions. The use of these cells lines in cell-based assays to identify umami and sweet taste modulatory compounds is also provided, particularly high throughput screening assays that detect receptor activity by use of fluorometric imaging.Finally, the invention relates to the discovery that some compounds, e.g., lactisole, inhibit both the activities of human T1R2/T1R3 and T1R1/T1R3 receptors, and accordingly the sweet and umami taste, suggesting that these receptors may be the only sweet and umami receptors.

公开(公告)号：US20170306408A1

公开(公告)日：2017-10-26

申请号：US15594775

申请日：2017-05-15

申请人： Behavioral Diagnostics, LLC

发明人： Robert Philibert ,  Anup Madan

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q1/6869 ,  C12Q2600/112 ,  C12Q2600/124 ,  C12Q2600/154 ,  Y10T436/143333 ,  C12Q2523/125

摘要： The present invention provides screening kits, compositions, and diagnostic methods for determining whether a subject has a predisposition to, or likelihood of having, a substance use disorder by determining a nucleic acid methylation profile from a biological sample from the subject, wherein a given profile indicates that the subject has a predisposition to a substance use disorder.

公开(公告)号：US20170159122A1

公开(公告)日：2017-06-08

申请号：US15129830

申请日：2014-03-28

申请人： Kunming Institute of Zoology, Chinese Acadermy of Sciences ,  Jiangxi Agricultural University

发明人： Yaping ZHANG ,  Lusheng HUANG ,  Haibing XIE ,  Jun REN ,  Huashui AI

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/124 ,  C12Q2600/156

摘要： Methods and kits useful for identifying a pig as producing an increased litter size are provided. Genetic makers, in particular SNP markers are provided that are useful in distinguishing pigs for a phenotype associated with increased litter size.

公开(公告)号：US20170058362A1

公开(公告)日：2017-03-02

申请号：US15253150

申请日：2016-08-31

申请人： Recombinetics, Inc.

发明人： Scott C. Fahrenkrug ,  Tad S. Sonstegard ,  Daniel F. Carlson

IPC分类号： C12Q1/68 ,  A01K67/027

CPC分类号： C12Q1/6888 ,  C12Q2600/124 ,  C12Q2600/156 ,  C12Q2600/172

摘要： Methods and kits to determine the presence of exogenous alleles within a native haplotype are provided. Introduction of foreign alleles into livestock genomes has provided the ability to introduce specific desirable traits. The present disclosure provides methods to identify the presence of exogenous alleles that foreign to a haplotype at a target locus, and identify specific markers that are native to the haplotype. Identification of exogenous genes at a target locus, flanked by native markers is indicative that the exogenous gene is present through molecular engineering. Conversely, the presence of an exogenous gene that are only partially flanked by native markers is indicative that the allele is present due to sexual breeding.

摘要翻译： 提供了确定天然单体型外源性等位基因存在的方法和试剂盒。 引入国外等位基因进入家畜基因组提供了引入特定理想性状的能力。 本公开提供了鉴定在目标基因座处单倍型外源的外源等位基因的存在的方法，并鉴定了该单体型天然的特异性标记。 在靶基因座上鉴定外源基因，侧接天然标记，表明外源基因通过分子工程存在。 相反地​​，只有部分被天然标记侧翼的外源基因的存在表明由于性繁殖而存在等位基因。