公开(公告)号：US06475750B1

公开(公告)日：2002-11-05

申请号：US09644323

申请日：2000-08-23

申请人： In Suk Han ,  You Han Bae ,  Dal Young Jung ,  Jules John Magda

发明人： In Suk Han ,  You Han Bae ,  Dal Young Jung ,  Jules John Magda

IPC分类号： C12Q154

CPC分类号： A61B5/14532 ,  A61B5/0002 ,  C12Q1/001 ,  C12Q1/006 ,  G01N7/00 ,  G01N13/04 ,  Y10T436/144444

摘要： A biosensor (10) has a hydrogel (30) in a rigid and referably biocompatible enclosure (20). The hydrogel (30) includes an immobilized glucose-binding molecule such as concanavalin A (Con A) and an immobilized hexose saccharide such as a-D-mannopyranoside. The immobilized hexose saccharide competitively binds with free glucose to the glucose-binding molecules, thus changing the number of crosslinks in the hydrogel (30), which changes hydrogel swelling tendency and the pressure of the hydrogel in its confined space in proportion to the concentration of free glucose. By measuring the change in hydrogel pressure with a pressure transducer (40), the biosensor (10) is able to accurately measure the concentration of the tree glucose molecule without the problem of oxygen limitations and interference encountered by prior art biosensors. A battery (64) powered telemeter (60) operably engaged to the pressure transducer (40) sends a radio data signal to a receiver (66) containing an alarm system operably attached to a computer (62). Furthermore, an alarm system utilizes such a sensor to automatically notify a person that the blood glucose level is outside a predetermined parameter, and/or to automatically inject an agent such as glucose or glycogen which will raise blood glucose levels.

摘要翻译： 生物传感器（10）具有在刚性和可实现的生物相容的外壳（20）中的水凝胶（30）。 水凝胶（30）包括固定化的葡萄糖结合分子如伴刀豆球蛋白A（Con A）和固定化的己糖如a-D-甘露吡喃糖苷。 固定的己糖与游离葡萄糖竞争性地结合葡萄糖结合分子，从而改变水凝胶中的交联数（30），其水凝胶膨胀趋势和密闭空间中水凝胶的压力与 游离葡萄糖。 通过用压力传感器（40）测量水凝胶压力的变化，生物传感器（10）能够精确地测量树葡萄糖分子的浓度，而不会受到现有技术生物传感器遇到的氧限制和干扰的问题。 可操作地接合到压力传感器（40）的电池（64）供电的遥测仪（60）将无线电数据信号发送到容纳可操作地附接到计算机（62）的报警系统的接收器（66）。 此外，报警系统利用这种传感器自动通知人血糖值超出预定参数，和/或自动注入葡萄糖或糖原的剂量，其将提高血糖水平。