公开(公告)号：US20150374980A1

公开(公告)日：2015-12-31

申请号：US14755840

申请日：2015-06-30

申请人： InCube Labs, LLC

发明人： Mir Imran ,  Mir Hashim ,  Glen McLaughlin ,  Huma Arastu ,  Rekha Vaidyanathan ,  Joel Harris ,  Radhika Korupolu ,  Andrew Mangogna ,  Chang Ong ,  Sanjay Patel ,  Lu Wang ,  Timothy Williams

IPC分类号： A61N1/32 ,  A61K31/4468 ,  A61K9/00 ,  A61N1/04

CPC分类号： A61N1/325 ,  A61K9/0009 ,  A61K9/0014 ,  A61K31/4178 ,  A61K31/4468 ,  A61K31/454 ,  A61K31/5415 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/303

摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

摘要翻译： 各种实施方案提供了用于治疗剂的双相离子电渗透皮递送的方法和系统。 用于这种传送的方法的实施例包括将至少一个电极组件定位成与患者的皮肤电连通。 组合件包括包含被动地扩散入皮肤的治疗剂的溶液。 使用具有例如极性和大小的特性的第一电流，在第一时段期间，将剂量的药剂从组合物递送到皮肤中，以将药剂排斥出组合体。 在第二时段期间，使用具有吸引剂的特性的第二电流将试剂保持在组合中，使得药剂递送到皮肤中最小化。 可以根据患者的输入要求递送剂量。 实施方案可以用于递送由不希望的被动扩散引起不利影响的试剂。

公开(公告)号：US20180064934A1

公开(公告)日：2018-03-08

申请号：US15679924

申请日：2017-08-17

申请人： InCube Labs, LLC

发明人： Mir Imran ,  Mir Hashim ,  Glen McLaughlin ,  Huma Arastu ,  Rekha Vaidyanathan ,  Joel Harris ,  Radhika Korupolu ,  Andrew Mangogna ,  Chang Ong ,  Sanjay Patel ,  Lu Wang ,  Timothy Williams

IPC分类号： A61N1/32 ,  A61K31/5415 ,  A61K31/454 ,  A61K31/4468 ,  A61K31/4178 ,  A61N1/04 ,  A61K9/00 ,  A61N1/30

摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

公开(公告)号：US10780266B2

公开(公告)日：2020-09-22

申请号：US15679924

申请日：2017-08-17

申请人： InCube Labs, LLC

发明人： Mir Imran ,  Mir Hashim ,  Glen McLaughlin ,  Huma Arastu ,  Rekha Vaidyanathan ,  Joel Harris ,  Radhika Korupolu ,  Andrew Mangogna ,  Chang Ong ,  Sanjay Patel ,  Lu Wang ,  Timothy Williams

IPC分类号： A61N1/32 ,  A61N1/04 ,  A61N1/30 ,  A61K9/00 ,  A61K31/4178 ,  A61K31/4468 ,  A61K31/454 ,  A61K31/5415

摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

公开(公告)号：US09764131B2

公开(公告)日：2017-09-19

申请号：US14755840

申请日：2015-06-30

申请人： InCube Labs, LLC

发明人： Mir Imran ,  Mir Hashim ,  Glen McLaughlin ,  Huma Arastu ,  Rekha Vaidyanathan ,  Joel Harris ,  Radhika Korupolu ,  Andrew Mangogna ,  Chang Ong ,  Sanjay Patel ,  Lu Wang ,  Timothy Williams

IPC分类号： A61N1/30 ,  A61N1/32 ,  A61N1/04 ,  A61K9/00 ,  A61K31/4178 ,  A61K31/4468 ,  A61K31/454 ,  A61K31/5415

CPC分类号： A61N1/325 ,  A61K9/0009 ,  A61K9/0014 ,  A61K31/4178 ,  A61K31/4468 ,  A61K31/454 ,  A61K31/5415 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/303

摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.