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公开(公告)号：US20240246982A1
公开(公告)日：2024-07-25
申请号：US18545545
申请日：2023-12-19
申请人： Incyte Corporation
发明人： Jiacheng Zhou , Shili Chen , Pingli Liu , David J. Meloni , Yongchun Pan , Naijing Su , Michael Xia
IPC分类号： C07D487/04 , C07D205/04 , C07D401/14
CPC分类号： C07D487/04 , C07D205/04 , C07D401/14
摘要： The present invention is related to processes for preparing itacitinib, or a salt thereof, and related synthetic intermediates related thereto.
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公开(公告)号：US20210040090A1
公开(公告)日：2021-02-11
申请号：US16987557
申请日：2020-08-07
申请人： Incyte Corporation
发明人： Zhongjiang Jia , Pingli Liu , David J. Meloni , Yongchun Pan , Yongzhong Wu , Jiacheng Zhou , Qun Li
IPC分类号： C07D471/04
摘要： The present invention relates to salt forms of the PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3′-(3-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2′-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid, including methods of preparation thereof, where the compound is useful in the treatment of various diseases including infectious diseases and cancer.
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公开(公告)号：US11753406B2
公开(公告)日：2023-09-12
申请号：US16987557
申请日：2020-08-07
申请人： Incyte Corporation
发明人： Zhongjiang Jia , Pingli Liu , David J. Meloni , Yongchun Pan , Yongzhong Wu , Jiacheng Zhou , Qun Li
IPC分类号： C07D471/04 , A61K9/00
CPC分类号： C07D471/04 , A61K9/0053 , C07B2200/13
摘要： The present invention relates to salt forms of the PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3′-(3-(((R)-3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-ylamino)-2,2′-dimethylbiphenyl-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid, including methods of preparation thereof, where the compound is useful in the treatment of various diseases including infectious diseases and cancer.
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公开(公告)号：US20160221996A1
公开(公告)日：2016-08-04
申请号：US15093486
申请日：2016-04-07
发明人： Ming Tao , William Frietze , David J. Meloni , Lingkai Weng , Jiacheng Zhou , Yongchun Pan
IPC分类号： C07D413/04
CPC分类号： C07D413/04 , C07C307/06 , C07D271/04 , C07D271/08
摘要： The present application is directed to processes and intermediates for making 4-({2-[(aminosulfonyl)amino]ethyl}amino)-N-(3-bromo-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide, which is an inhibitor of indoleamine 2,3-dioxygenase, useful in the treatment of cancer and other disorders.
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公开(公告)号：US09067921B2
公开(公告)日：2015-06-30
申请号：US14176781
申请日：2014-02-10
申请人： Incyte Corporation
发明人： Chu-Biao Xue , Ganfeng Cao , Taisheng Huang , Lihua Chen , Ke Zhang , Anlai Wang , David J. Meloni , Rajan Anand , Joseph Glenn , Brian W. Metcalf
IPC分类号： A61K31/497 , C07D401/14 , A61K31/496 , A61K45/06 , C07D401/06 , C07D417/14 , C07D471/04 , A61K31/502 , A61K31/506
CPC分类号： C07D401/14 , A61K31/496 , A61K31/502 , A61K31/506 , A61K45/06 , C07D401/06 , C07D417/14 , C07D471/04 , A61K2300/00
摘要： The present invention relates to compounds of Formula I: wherein variable substituents are defined herein, that modulate the activity of or bind to chemokine receptors such as CCR5. In some embodiments, the compounds of the invention are selective for CCR5. The compounds can be used, for example, to treat diseases associated with chemokine receptor expression or activity such as inflammatory diseases, immune diseases and viral infections.
摘要翻译： 本发明涉及式I化合物：其中可变取代基在本文中定义，其调节趋化因子受体如CCR5的活性或与其结合。 在一些实施方案中，本发明的化合物对CCR5是选择性的。 该化合物可用于例如治疗与趋化因子受体表达或活性相关的疾病，例如炎性疾病，免疫疾病和病毒感染。
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公开(公告)号：US20240166655A1
公开(公告)日：2024-05-23
申请号：US18541579
申请日：2023-12-15
申请人： Incyte Corporation
发明人： Jiacheng Zhou , Shili Chen , Pingli Liu , David J. Meloni , James M. Parks , Yongchun Pan , Naijing Su , Michael Xia , Weiguo Liu
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07B2200/13
摘要： The present invention is related to processes for preparing ruxolitinib, or a salt thereof, and related synthetic intermediates related thereto.
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公开(公告)号：US10280157B2
公开(公告)日：2019-05-07
申请号：US15852995
申请日：2017-12-22
发明人： Ming Tao , William Frietze , David J. Meloni , Lingkai Weng , Jiacheng Zhou , Yongchun Pan
IPC分类号： C07D413/04 , C07D271/04 , C07D271/08 , C07C307/06
摘要： The present application is directed to processes and intermediates for making 4-({2-[(aminosulfonyl)amino]ethyl}amino)-N-(3-bromo-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide, which is an inhibitor of indoleamine 2,3-dioxygenase, useful in the treatment of cancer and other disorders.
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公开(公告)号：US11897889B2
公开(公告)日：2024-02-13
申请号：US17404461
申请日：2021-08-17
申请人： Incyte Corporation
发明人： Jiacheng Zhou , Shili Chen , Pingli Liu , David J. Meloni , Yongchun Pan , Naijing Su , Michael Xia
IPC分类号： C07D487/04 , C07D205/04 , C07D401/14
CPC分类号： C07D487/04 , C07D205/04 , C07D401/14
摘要： The present invention is related to processes for preparing itacitinib, or a salt thereof, and related synthetic intermediates related thereto.
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公开(公告)号：US09873688B2
公开(公告)日：2018-01-23
申请号：US15093486
申请日：2016-04-07
发明人： Ming Tao , William Frietze , David J. Meloni , Lingkai Weng , Jiacheng Zhou , Yongchun Pan
IPC分类号： C07D413/04 , C07D271/08 , C07D271/07 , C07C307/06 , C07D271/04
CPC分类号： C07D413/04 , C07C307/06 , C07D271/04 , C07D271/08
摘要： The present application is directed to processes and intermediates for making 4-({2-[(aminosulfonyl)amino]ethyl}amino)-N-(3-bromo-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide, which is an inhibitor of indoleamine 2,3-dioxygenase, useful in the treatment of cancer and other disorders.
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公开(公告)号：US11905292B2
公开(公告)日：2024-02-20
申请号：US17404613
申请日：2021-08-17
申请人： Incyte Corporation
发明人： Jiacheng Zhou , Shili Chen , Pingli Liu , David J. Meloni , James M. Parks , Yongchun Pan , Naijing Su , Michael Xia , Weiguo Liu
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , C07B2200/13
摘要： The present invention is related to processes for preparing ruxolitinib, or a salt thereof, and related synthetic intermediates related thereto.
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