公开(公告)号：US12083124B2

公开(公告)日：2024-09-10

申请号：US18159798

申请日：2023-01-26

申请人： Incyte Corporation

发明人： Oleg Vechorkin ,  Minh Nguyen ,  Chao Qi ,  Anlai Wang ,  Michael Witten ,  Yao Xu ,  Hai Fen Ye ,  Ke Zhang ,  Peng Zhao ,  Wenqing Yao

IPC分类号： A61K31/5377 ,  A61K31/437 ,  A61K31/496 ,  A61K31/4995 ,  A61P35/00 ,  C07D471/04 ,  C07D519/00

CPC分类号： A61K31/5377 ,  A61K31/437 ,  A61K31/496 ,  A61K31/4995 ,  A61P35/00 ,  C07D471/04 ,  C07D519/00

摘要： The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.

公开(公告)号：US20210106588A1

公开(公告)日：2021-04-15

申请号：US17070160

申请日：2020-10-14

申请人： Incyte Corporation

发明人： Oleg Vechorkin ,  Minh Nguyen ,  Chao Qi ,  Anlai Wang ,  Michael Witten ,  Yao Xu ,  Hai Fen Ye ,  Ke Zhang ,  Peng Zhao ,  Wenqing Yao

IPC分类号： A61K31/5377 ,  A61P35/00 ,  C07D471/04 ,  A61K31/437 ,  A61K31/496 ,  A61K31/4995 ,  C07D519/00

摘要： The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.

公开(公告)号：US11607416B2

公开(公告)日：2023-03-21

申请号：US17070160

申请日：2020-10-14

申请人： Incyte Corporation

发明人： Oleg Vechorkin ,  Minh Nguyen ,  Chao Qi ,  Anlai Wang ,  Michael Witten ,  Yao Xu ,  Hai Fen Ye ,  Ke Zhang ,  Peng Zhao ,  Wenqing Yao

IPC分类号： A61K31/5377 ,  A61P35/00 ,  A61K31/437 ,  A61K31/496 ,  A61K31/4995 ,  C07D471/04 ,  C07D519/00

摘要： The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.

公开(公告)号：US20230338389A1

公开(公告)日：2023-10-26

申请号：US18159798

申请日：2023-01-26

申请人： Incyte Corporation

发明人： Oleg Vechorkin ,  Minh Nguyen ,  Chao Qi ,  Anlai Wang ,  Michael Witten ,  Yao Xu ,  Hai Fen Ye ,  Ke Zhang ,  Peng Zhao ,  Wenqing Yao

IPC分类号： A61K31/5377 ,  A61P35/00 ,  A61K31/437 ,  A61K31/496 ,  A61K31/4995 ,  C07D471/04 ,  C07D519/00

CPC分类号： A61K31/5377 ,  A61P35/00 ,  A61K31/437 ,  A61K31/496 ,  A61K31/4995 ,  C07D471/04 ,  C07D519/00

摘要： The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.