公开(公告)号：US20210205311A1

公开(公告)日：2021-07-08

申请号：US17138485

申请日：2020-12-30

申请人： Incyte Corporation

发明人： Hui Wang ,  Juan Carlos Almagro ,  Rebecca A. Buonpane ,  Peter Niels Carlsen ,  Taisheng Huang ,  Yong Li ,  Luping Lin ,  Horacio G. Nastri ,  Chao Qi ,  Shaun M. Stewart ,  Pramod Unnikrishnan Thekkat ,  Xiaozhao Wang ,  Liangxing Wu ,  Wenqing Yao ,  Jing Zhou ,  Wenyu Zhu

IPC分类号： A61K31/519 ,  A61K39/395 ,  A61P35/00 ,  A61K31/501 ,  A61K31/506 ,  A61K31/4985 ,  A61K31/444

摘要： The present application provides methods of treating cancer using a combination of an inhibitor of A2A and/or A2B and an inhibitor of PD-1 and/or PD-L1.

公开(公告)号：US20210139485A1

公开(公告)日：2021-05-13

申请号：US17077713

申请日：2020-10-22

申请人： Incyte Corporation

发明人： Xiaozhao Wang ,  Pei Gan ,  Heeoon Han ,  Taisheng Huang ,  Matthew S. McCammant ,  Chao Qi ,  Ding-Quan Qian ,  Liangxing Wu ,  Wenqing Yao ,  Zhiyong Yu ,  Fenglei Zhang

IPC分类号： C07D487/04 ,  C07D491/056 ,  C07D519/00 ,  A61P35/00 ,  A61P25/00 ,  A61P9/00 ,  A61P29/00

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20200031835A1

公开(公告)日：2020-01-30

申请号：US16502826

申请日：2019-07-03

申请人： Incyte Corporation

发明人： Xiaozhao Wang ,  Peter Niels Carlsen ,  Pei Gan ,  Gia Hoang ,  Yong Li ,  Chao Qi ,  Liangxing Wu ,  Wenqing Yao ,  Zhiyong Yu ,  Wenyu Zhu

IPC分类号： C07D487/04 ,  C07D519/00

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US11939328B2

公开(公告)日：2024-03-26

申请号：US18046303

申请日：2022-10-13

申请人： Incyte Corporation

发明人： Qinda Ye ,  Matthew McCammant ,  Artem Shvartsbart ,  Wenyu Zhu ,  Bin Hu ,  Chao Qi ,  Xiaozhao Wang ,  Wenqing Yao ,  Alexander Sokolsky

IPC分类号： C07D471/04 ,  A61P35/00

CPC分类号： C07D471/04 ,  A61P35/00

摘要： Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

公开(公告)号：US20230357255A1

公开(公告)日：2023-11-09

申请号：US18300349

申请日：2023-04-13

申请人： Incyte Corporation

发明人： Xiaozhao Wang ,  Pei Gan ,  Taisheng Huang ,  Chao Qi ,  Ding-Quan Qian ,  Liangxing Wu ,  Wenqing Yao ,  Zhiyong Yu ,  Fenglei Zhang ,  Le Zhao ,  Chunhong He

IPC分类号： C07D487/04 ,  C07D491/056 ,  C07D519/00 ,  A61P35/00 ,  A61P25/00 ,  A61P9/00 ,  A61P29/00

CPC分类号： C07D487/04 ,  C07D491/056 ,  C07D519/00 ,  A61P35/00 ,  A61P25/00 ,  A61P9/00 ,  A61P29/00

摘要： This application relates to compounds of Formula (I):




or pharmaceutically acceptable salts or stereoisomers thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US11607416B2

公开(公告)日：2023-03-21

申请号：US17070160

申请日：2020-10-14

申请人： Incyte Corporation

发明人： Oleg Vechorkin ,  Minh Nguyen ,  Chao Qi ,  Anlai Wang ,  Michael Witten ,  Yao Xu ,  Hai Fen Ye ,  Ke Zhang ,  Peng Zhao ,  Wenqing Yao

IPC分类号： A61K31/5377 ,  A61P35/00 ,  A61K31/437 ,  A61K31/496 ,  A61K31/4995 ,  C07D471/04 ,  C07D519/00

摘要： The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.

公开(公告)号：US11591329B2

公开(公告)日：2023-02-28

申请号：US16923799

申请日：2020-07-08

申请人： Incyte Corporation

发明人： Oleg Vechorkin ,  Chao Qi ,  Minh Nguyen ,  Anlai Wang ,  Wenqing Yao

IPC分类号： C07D471/04 ,  C07D519/00 ,  A61K45/06

摘要： The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR3 enzyme and are useful in the treatment of FGFR3-associated diseases such as cancer.

公开(公告)号：US11161850B2

公开(公告)日：2021-11-02

申请号：US16502826

申请日：2019-07-03

申请人： Incyte Corporation

发明人： Xiaozhao Wang ,  Yong Li ,  Chao Qi ,  Liangxing Wu ,  Wenqing Yao ,  Wenyu Zhu

IPC分类号： A61P9/00 ,  A61P25/28 ,  A61P35/00 ,  A61P29/00 ,  C07D519/00 ,  C07D487/04

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US20190292188A1

公开(公告)日：2019-09-26

申请号：US16285787

申请日：2019-02-26

申请人： Incyte Corporation

发明人： Xiaozhao Wang ,  Pei Gan ,  Heeoon Han ,  Taisheng Huang ,  Matthew S. McCammant ,  Chao Qi ,  Ding-Quan Qian ,  Liangxing Wu ,  Wenqing Yao ,  Zhiyong Yu ,  Fenglei Zhang

IPC分类号： C07D487/04 ,  C07D491/056 ,  C07D519/00

摘要： This application relates to compounds of Formula (I): or pharmaceutically acceptable salts or stereoisomers thereof, which modulate the activity of adenosine receptors, such as subtypes A2A and A2B receptors, and are useful in the treatment of diseases related to the activity of adenosine receptors including, for example, cancer, inflammatory diseases, cardiovascular diseases, and neurodegenerative diseases.

公开(公告)号：US12083124B2

公开(公告)日：2024-09-10

申请号：US18159798

申请日：2023-01-26

申请人： Incyte Corporation

发明人： Oleg Vechorkin ,  Minh Nguyen ,  Chao Qi ,  Anlai Wang ,  Michael Witten ,  Yao Xu ,  Hai Fen Ye ,  Ke Zhang ,  Peng Zhao ,  Wenqing Yao

IPC分类号： A61K31/5377 ,  A61K31/437 ,  A61K31/496 ,  A61K31/4995 ,  A61P35/00 ,  C07D471/04 ,  C07D519/00

CPC分类号： A61K31/5377 ,  A61K31/437 ,  A61K31/496 ,  A61K31/4995 ,  A61P35/00 ,  C07D471/04 ,  C07D519/00

摘要： The present invention relates to bicyclic heterocycles, and pharmaceutical compositions of the same, that are inhibitors of the FGFR enzyme and are useful in the treatment of FGFR-associated diseases such as cancer.