公开(公告)号：US08859491B2

公开(公告)日：2014-10-14

申请号：US13679121

申请日：2012-11-16

Applicant: Indiana University Research and Technology Corporation

Inventor： Richard D. DiMarchi ,  Bin Yang

IPC: A61K38/00 ,  C07K14/605 ,  A61K38/26 ,  A61K31/56

CPC classification number: C07K14/605 ,  A61K38/00 ,  A61K47/554 ,  C07K2319/715

Abstract: Provided herein are glucagon superfamily peptides conjugated with GR ligands that are capable of acting at a glucocorticoid receptor. Also provided herein are pharmaceutical compositions and kits of the conjugates of the invention. Further provided herein are methods of treating a disease, e.g., a metabolic disorder, such as diabetes and obesity, comprising administering the conjugates of the invention.

Abstract translation: 本文提供了与能够作用于糖皮质激素受体的GR配体缀合的胰高血糖素超家族肽。 本文还提供了本发明的缀合物的药物组合物和试剂盒。 本文还提供了治疗疾病，例如代谢紊乱（例如糖尿病和肥胖症）的方法，其包括施用本发明的缀合物。

公开(公告)号：US09783592B2

公开(公告)日：2017-10-10

申请号：US14808668

申请日：2015-07-24

Applicant: Indiana University Research and Technology Corporation

Inventor： Richard D. DiMarchi ,  Bin Yang ,  Brian Finan

IPC: C07K14/605 ,  A61K38/26 ,  C07K14/72 ,  A61K47/48

CPC classification number: C07K14/721 ,  A61K38/26 ,  A61K47/55 ,  A61K47/554 ,  A61K47/64 ,  C07K14/605 ,  C07K14/72

Abstract: Provided herein are glucagon superfamily peptides conjugated with NHR ligands that are capable of acting at a nuclear hormone receptor. Also provided herein are pharmaceutical compositions and kits of the conjugates of the invention. Further provided herein are methods of treating a disease, e.g., a metabolic disorder, such as diabetes and obesity, comprising administering the conjugates of the invention.