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Patent Agency Ranking
1.发明申请公开(公告)号：US20200261386A1
公开(公告)日：2020-08-20
申请号：US16792950
申请日：2020-02-18
Inventor： Jeffrey A. Kline , Nathan J. Alves , Daren M. Beam
Abstract: Compositions and methods for therapeutic delivery are disclosed. More particularly, the present disclosure relates to nanoparticle compositions that sequester the activity of a target molecule while leaving other domains accessible to bind targeted tissues of interest. Methods for thrombus dissolution include administering a nanoparticle reversibly coupled to a target molecule that can dissolve a blood clot. Compositions and methods for inducing blood clotting are also disclosed. Methods for inducing blood clotting include administering a nanoparticle reversibly coupled to a target molecule that can induce the formation of a blood clot. Methods for sequestering a target molecule are also disclosed. The method includes reversibly coupling a target molecule to a nanoparticle having an affinity ligand that reversibly couples the target molecule, and thus, sequesters the target molecule activity until the target molecule interacts with its substrate resulting in the release of the target molecule.
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2.发明申请公开(公告)号：US20170189362A1
公开(公告)日：2017-07-06
申请号：US15501905
申请日：2015-08-04
Inventor： Jeffrey A. Kline , Nathan J. Alves , Daren M. Beam
IPC: A61K31/196 , A61K45/06 , A61K38/48
CPC classification number: A61K31/196 , A61K9/127 , A61K38/482 , A61K38/4833 , A61K38/484 , A61K38/4846 , A61K38/4853 , A61K38/486 , A61K38/4866 , A61K38/49 , A61K45/06 , A61K47/544 , A61K47/6909 , A61K47/6911 , A61K47/6929 , B82Y5/00 , C12Y304/21 , C12Y304/21001 , C12Y304/21004 , C12Y304/21005 , C12Y304/21007 , C12Y304/21008 , C12Y304/21027 , C12Y304/21034 , C12Y304/21036 , C12Y304/21069 , Y10S977/773 , Y10S977/906 , Y10S977/907
Abstract: Compositions and methods for therapeutic delivery are disclosed. More particularly, the present disclosure relates to nanoparticle compositions that sequester the activity of a target molecule while leaving other domains accessible to bind targeted tissues of interest. Methods for thrombus dissolution include administering a nanoparticle reversibly coupled to a target molecule that can dissolve a blood clot. Compositions and methods for inducing blood clotting are also disclosed. Methods for inducing blood clotting include administering a nanoparticle reversibly coupled to a target molecule that can induce the formation of a blood clot. Methods for sequestering a target molecule are also disclosed. The method includes reversibly coupling a target molecule to a nanoparticle having an affinity ligand that reversibly couples the target molecule, and thus, sequesters the target molecule activity until the target molecule interacts with its substrate resulting in the release of the target molecule.
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公开(公告)号：US20220218639A1
公开(公告)日：2022-07-14
申请号：US17529420
申请日：2021-11-18
Inventor： Jeffrey A. Kline , Nathan J. Alves , Daren M. Beam
Abstract: Compositions and methods for therapeutic delivery are disclosed. More particularly, the present disclosure relates to nanoparticle compositions that sequester the activity of a target molecule while leaving other domains accessible to bind targeted tissues of interest. Methods for thrombus dissolution include administering a nanoparticle reversibly coupled to a target molecule that can dissolve a blood clot. Compositions and methods for inducing blood clotting are also disclosed. Methods for inducing blood clotting include administering a nanoparticle reversibly coupled to a target molecule that can induce the formation of a blood clot. Methods for sequestering a target molecule are also disclosed. The method includes reversibly coupling a target molecule to a nanoparticle having an affinity ligand that reversibly couples the target molecule, and thus, sequesters the target molecule activity until the target molecule interacts with its substrate resulting in the release of the target molecule.
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公开(公告)号：US10583104B2
公开(公告)日：2020-03-10
申请号：US15501905
申请日：2015-08-04
Inventor： Jeffrey A. Kline , Nathan J. Alves , Daren M. Beam
Abstract: Compositions and methods for therapeutic delivery are disclosed. More particularly, the present disclosure relates to nanoparticle compositions that sequester the activity of a target molecule while leaving other domains accessible to bind targeted tissues of interest. Methods for thrombus dissolution include administering a nanoparticle reversibly coupled to a target molecule that can dissolve a blood clot. Compositions and methods for inducing blood clotting are also disclosed. Methods for inducing blood clotting include administering a nanoparticle reversibly coupled to a target molecule that can induce the formation of a blood clot. Methods for sequestering a target molecule are also disclosed. The method includes reversibly coupling a target molecule to a nanoparticle having an affinity ligand that reversibly couples the target molecule, and thus, sequesters the target molecule activity until the target molecule interacts with its substrate resulting in the release of the target molecule.
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公开(公告)号：US11207282B2
公开(公告)日：2021-12-28
申请号：US16792950
申请日：2020-02-18
Inventor： Jeffrey A. Kline , Nathan J. Alves , Daren M. Beam
Abstract: Compositions and methods for therapeutic delivery are disclosed. More particularly, the present disclosure relates to nanoparticle compositions that sequester the activity of a target molecule while leaving other domains accessible to bind targeted tissues of interest. Methods for thrombus dissolution include administering a nanoparticle reversibly coupled to a target molecule that can dissolve a blood clot. Compositions and methods for inducing blood clotting are also disclosed. Methods for inducing blood clotting include administering a nanoparticle reversibly coupled to a target molecule that can induce the formation of a blood clot. Methods for sequestering a target molecule are also disclosed. The method includes reversibly coupling a target molecule to a nanoparticle having an affinity ligand that reversibly couples the target molecule, and thus, sequesters the target molecule activity until the target molecule interacts with its substrate resulting in the release of the target molecule.
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