公开(公告)号：US20190350912A1

公开(公告)日：2019-11-21

申请号：US16339042

申请日：2017-10-03

Applicant: Indiana University Research and Technology Corporation

Inventor： Jian-Ting Zhang ,  Jian-Yuan Liu

IPC: A61K31/4439 ,  A61K31/502 ,  A61K31/454 ,  A61K31/137 ,  A61K31/5025 ,  A61K31/4184 ,  A61K31/55 ,  A61P35/00

Abstract: Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reduction of resistance to the treatment, prevention, and/or diagnosis of diseases characterized by the formation of cancers. Embodiments include methods of treating cancer, comprising the steps of: providing a patient diagnosed with cancer with a therapeutic regime that includes at least one therapeutically effective dose of at least one agent that reduces the activity of at least one DNA damage/repair pathway. Other embodiments include methods of treating cancer, comprising the steps of: treating a patient diagnosed with cancer with a combination of therapeutic agents that includes at least one therapeutically effective anti-cancer agent and at least one compound that reduces the activity of at least one DNA damage/repair pathway. Yet other embodiments include methods of reducing resistance to a genotoxic therapeutic, comprising the steps of: treating a patient at least one therapeutically effective dose of at least one agent that reduces at least one DNA damage/repair pathway.

公开(公告)号：US11491147B2

公开(公告)日：2022-11-08

申请号：US16339042

申请日：2017-10-03

Applicant: Indiana University Research and Technology Corporation

Inventor： Jian-Ting Zhang ,  Jian-Yuan Liu

IPC: A61K31/4439 ,  A61P35/00 ,  A61K31/137 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/55

Abstract: Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reduction of resistance to the treatment, prevention, and/or diagnosis of diseases characterized by the formation of cancers. Embodiments include methods of treating cancer, comprising the steps of: providing a patient diagnosed with cancer with a therapeutic regime that includes at least one therapeutically effective dose of at least one agent that reduces the activity of at least one DNA damage/repair pathway. Other embodiments include methods of treating cancer, comprising the steps of: treating a patient diagnosed with cancer with a combination of therapeutic agents that includes at least one therapeutically effective anti-cancer agent and at least one compound that reduces the activity of at least one DNA damage/repair pathway. Yet other embodiments include methods of reducing resistance to a genotoxic therapeutic, comprising the steps of: treating a patient at least one therapeutically effective dose of at least one agent that reduces at least one DNA damage/repair pathway.