公开(公告)号：US12115158B2

公开(公告)日：2024-10-15

申请号：US17195166

申请日：2021-03-08

Applicant: Indiana University Research and Technology Corporation

Inventor： Jian-Ting Zhang ,  Jing-Yuan Liu ,  Mingji Dai

IPC: A61K31/4985 ,  A61K31/498 ,  A61P35/00

CPC classification number: A61K31/4985 ,  A61K31/498 ,  A61P35/00

Abstract: Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions containing such compounds are also disclosed, along with general methods of identifying anti-cancer compounds that target oncogenic dimeric proteins. Exemplary compounds that can be used in the disclosed methods of treatment and pharmaceutical compositions have the chemical structures disclosed in the specification.

公开(公告)号：US11491147B2

公开(公告)日：2022-11-08

申请号：US16339042

申请日：2017-10-03

Applicant: Indiana University Research and Technology Corporation

Inventor： Jian-Ting Zhang ,  Jian-Yuan Liu

IPC: A61K31/4439 ,  A61P35/00 ,  A61K31/137 ,  A61K31/4184 ,  A61K31/454 ,  A61K31/502 ,  A61K31/5025 ,  A61K31/55

Abstract: Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reduction of resistance to the treatment, prevention, and/or diagnosis of diseases characterized by the formation of cancers. Embodiments include methods of treating cancer, comprising the steps of: providing a patient diagnosed with cancer with a therapeutic regime that includes at least one therapeutically effective dose of at least one agent that reduces the activity of at least one DNA damage/repair pathway. Other embodiments include methods of treating cancer, comprising the steps of: treating a patient diagnosed with cancer with a combination of therapeutic agents that includes at least one therapeutically effective anti-cancer agent and at least one compound that reduces the activity of at least one DNA damage/repair pathway. Yet other embodiments include methods of reducing resistance to a genotoxic therapeutic, comprising the steps of: treating a patient at least one therapeutically effective dose of at least one agent that reduces at least one DNA damage/repair pathway.

公开(公告)号：US20210299123A1

公开(公告)日：2021-09-30

申请号：US17195166

申请日：2021-03-08

Applicant: Indiana University Research and Technology Corporation

Inventor： Jian-Ting Zhang ,  Jing-Yuan Liu ,  Mingji Dai

IPC: A61K31/4985 ,  A61K31/498 ,  A61P35/00

Abstract: Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions containing such compounds are also disclosed, along with general methods of identifying anti-cancer compounds that target oncogenic dimeric proteins. Exemplary compounds that can be used in the disclosed methods of treatment and pharmaceutical compositions have the chemical structures disclosed in the specification.

公开(公告)号：US20200222398A1

公开(公告)日：2020-07-16

申请号：US16716574

申请日：2019-12-17

Applicant: Indiana University Research and Technology Corporation

Inventor： Jian-Ting Zhang ,  Liu Jing-Yuan

IPC: A61K31/4985 ,  A61P35/00

Abstract: Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions containing such compounds are also disclosed, along with general methods of identifying anti-cancer compounds that target oncogenic dimeric proteins. Exemplary compounds that can be used in the disclosed methods of treatment and pharmaceutical compositions have the chemical structure:

公开(公告)号：US10517871B2

公开(公告)日：2019-12-31

申请号：US15573867

申请日：2016-05-13

Applicant: Indiana University Research and Technology Corporation

Inventor： Jian-Ting Zhang ,  Jing-Yuan Liu

IPC: A61K31/4985 ,  A61P35/02 ,  G01N33/50

Abstract: Methods for treating various cancers by administering one or more compounds that target the dimeric protein survivin are disclosed. Pharmaceutical compositions containing such compounds are also disclosed, along with general methods of identifying anti-cancer compounds that target oncogenic dimeric proteins. Exemplary compounds that can be used in the disclosed methods of treatment and pharmaceutical compositions have the chemical structure.

公开(公告)号：US20190350912A1

公开(公告)日：2019-11-21

申请号：US16339042

申请日：2017-10-03

Applicant: Indiana University Research and Technology Corporation

Inventor： Jian-Ting Zhang ,  Jian-Yuan Liu

IPC: A61K31/4439 ,  A61K31/502 ,  A61K31/454 ,  A61K31/137 ,  A61K31/5025 ,  A61K31/4184 ,  A61K31/55 ,  A61P35/00

Abstract: Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reduction of resistance to the treatment, prevention, and/or diagnosis of diseases characterized by the formation of cancers. Embodiments include methods of treating cancer, comprising the steps of: providing a patient diagnosed with cancer with a therapeutic regime that includes at least one therapeutically effective dose of at least one agent that reduces the activity of at least one DNA damage/repair pathway. Other embodiments include methods of treating cancer, comprising the steps of: treating a patient diagnosed with cancer with a combination of therapeutic agents that includes at least one therapeutically effective anti-cancer agent and at least one compound that reduces the activity of at least one DNA damage/repair pathway. Yet other embodiments include methods of reducing resistance to a genotoxic therapeutic, comprising the steps of: treating a patient at least one therapeutically effective dose of at least one agent that reduces at least one DNA damage/repair pathway.