公开(公告)号：US20150045435A1

公开(公告)日：2015-02-12

申请号：US14452910

申请日：2014-08-06

Applicant: Indiana University Research and Technology Corporation

Inventor： William L. Scott ,  Martin J. O'Donnell

IPC: C07C233/63

CPC classification number: C07C233/63 ,  C07B2200/07 ,  C07C2601/02 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2601/18 ,  C07D215/48

Abstract: The invention described herein pertains to compounds, compositions, methods and uses thereof. The compounds described herein are in a class of glucose-lowering drugs useful for treating diabetes. Generally, compounds of the Formula I are described herein.

Abstract translation: 本文描述的本发明涉及其化合物，组合物，方法和用途。 本文所述的化合物是用于治疗糖尿病的一类降血糖药物。 通常，本文描述式I的化合物。

公开(公告)号：US20180215704A1

公开(公告)日：2018-08-02

申请号：US15869865

申请日：2018-01-12

Applicant: Indiana University Research and Technology Corporation

Inventor： William L. Scott ,  Martin J. O'Donnell ,  Jack Geno Samaritoni

IPC: C07C237/20 ,  C07C229/34 ,  C07D207/08 ,  C07D295/13 ,  C07D213/40 ,  C07D211/32

CPC classification number: C07C237/20 ,  C07C229/34 ,  C07D207/08 ,  C07D211/32 ,  C07D213/40 ,  C07D295/13

Abstract: Amides substituted with aromatic groups were synthesized and some were purified to create enantiomer pure compounds. The compounds were tested to determine their ability to inhibit the growth of bacteria and the formation of biofilms created by bacteria. Some of these compounds were found to be effective antibacterials and to effectively inhibit the formation of biofilms.

公开(公告)号：US20170044097A1

公开(公告)日：2017-02-16

申请号：US15237258

申请日：2016-08-15

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： William L. Scott ,  Martin J. O'Donnell ,  Jack Geno Samaritoni

IPC: C07C237/20 ,  C07D207/08 ,  C07D211/32 ,  C07D213/40 ,  C07D295/13

CPC classification number: C07C237/20 ,  C07C229/34 ,  C07D207/08 ,  C07D211/32 ,  C07D213/40 ,  C07D295/13

Abstract: Amides substituted with aromatic groups were synthesized and some were purified to create enantiomer pure compounds. The compounds were tested to determine their ability to inhibit the growth of bacteria and the formation of biofilms created by bacteria. Some of these compounds were found to be effective antibacterials and to effectively inhibit the formation of biofilms.

Abstract translation: 合成了被芳基取代的酰胺，并将一些纯化得到对映体纯化合物。 测试化合物以确定其抑制细菌生长和由细菌产生的生物膜形成的能力。 发现这些化合物中的一些是有效的抗菌剂并有效抑制生物膜的形成。

公开(公告)号：US10919844B2

公开(公告)日：2021-02-16

申请号：US15869865

申请日：2018-01-12

Applicant: Indiana University Research and Technology Corporation

Inventor： William L. Scott ,  Martin J. O'Donnell ,  Jack Geno Samaritoni

IPC: C07C237/20 ,  C07C229/34 ,  C07D213/40 ,  C07D295/13 ,  C07D211/32 ,  C07D207/08

Abstract: Amides substituted with aromatic groups were synthesized and some were purified to create enantiomer pure compounds. The compounds were tested to determine their ability to inhibit the growth of bacteria and the formation of biofilms created by bacteria. Some of these compounds were found to be effective antibacterials and to effectively inhibit the formation of biofilms.