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公开(公告)号：US20180305420A1
公开(公告)日：2018-10-25
申请号：US15771036
申请日：2016-10-28
Inventor： Tarek Maurice Ashkar , Radmila Micanovic
CPC classification number: C07K14/47 , A61K35/00 , A61K35/22 , A61K38/00 , A61K38/1709 , A61P13/12 , C07K14/435
Abstract: Embodiments of the present disclosure provide polypeptides, related materials and compositions, and methods for their use. In certain embodiments, the present disclosure provides a monomeric Tamm-Horsfall Protein polypeptide, or a biologically active truncation thereof. Other embodiments provide polynucleotides encoding a polypeptide described herein, nucleic acid expression vectors including the polynucleotides, and recombinant host cells including the expression vector. Yet other embodiments provide pharmaceutical compositions including a polypeptide described herein. Also provided are methods for treating a renal disease, disorder, or condition in a subject and/or modulating an immune response in a subject.
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公开(公告)号：US11053290B2
公开(公告)日：2021-07-06
申请号：US15771036
申请日：2016-10-28
Inventor： Tarek Maurice Ashkar , Radmila Micanovic
Abstract: Embodiments of the present disclosure provide polypeptides, related materials and compositions, and methods for their use. In certain embodiments, the present disclosure provides a monomeric Tamm-Horsfall Protein polypeptide, or a biologically active truncation thereof. Other embodiments provide polynucleotides encoding a polypeptide described herein, nucleic acid expression vectors including the polynucleotides, and recombinant host cells including the expression vector. Yet other embodiments provide pharmaceutical compositions including a polypeptide described herein. Also provided are methods for treating a renal disease, disorder, or condition in a subject and/or modulating an immune response in a subject.
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