公开(公告)号：US11324398B2

公开(公告)日：2022-05-10

申请号：US16522183

申请日：2019-07-25

Applicant: Indiana University Research and Technology Corporation

Inventor： Donald Thomas Miller ,  Zhuolin Liu ,  Kazuhiro Suzuki ,  Furu Zhang

IPC: A61B3/00 ,  A61B3/10 ,  A61B3/12 ,  A61B3/13 ,  A61B3/14

Abstract: A method is provided for observing structure and function of individual cells in a living human eye, comprising: using an adaptive optics optical coherence tomography (AO-OCT) system to image a volume of a retinal patch including numerous cells of different types, as for example, ganglion cells; using 3D subcellular image registration to correct for eye motion, including digitally dissecting the imaged volume; and using organelle motility inside the cell to increase cell contrast and to measure cell temporal dynamics.

公开(公告)号：US20200022575A1

公开(公告)日：2020-01-23

申请号：US16522183

申请日：2019-07-25

Applicant: Indiana University Research and Technology Corporation

Inventor： Donald Thomas Miller ,  Zhuolin Liu ,  Kazuhiro Suzuki ,  Furu Zhang

IPC: A61B3/00 ,  A61B3/10 ,  A61B3/14 ,  A61B3/13 ,  A61B3/12

Abstract: A method is provided for observing structure and function of individual cells in a living human eye, comprising: using an adaptive optics optical coherence tomography (AO-OCT) system to image a volume of a retinal patch including numerous cells of different types, as for example, ganglion cells; using 3D subcellular image registration to correct for eye motion, including digitally dissecting the imaged volume; and using organelle motility inside the cell to increase cell contrast and to measure cell temporal dynamics.