公开(公告)号：US12152035B2

公开(公告)日：2024-11-26

申请号：US17561055

申请日：2021-12-23

Applicant: Industrial Technology Research Institute

Inventor： Chih-Wei Fu ,  Hao-Hsuan Liu ,  Chiu-Lien Hung ,  Yu-Chin Lin ,  Tsan-Lin Hu ,  Chien-Chin Huang

IPC: C07D487/04 ,  A61P35/00 ,  C07D401/04 ,  C07D401/14 ,  C07D417/12 ,  C07D417/14

Abstract: An androgen receptor (AR) binding molecule has the structure of Formula (I) shown in the following: wherein E is CH2, G is CH, is OH, NH2, OTf or C≡C, X is CF3 or trifluoromethylphenyl, is a single bond, and Y and Z are CH2; or is absent, X is CF3, is a double bond, and Y and Z are CH.