公开(公告)号：US20220363645A1

公开(公告)日：2022-11-17

申请号：US17117615

申请日：2020-12-10

Applicant: Industrial Technology Research Institute

Inventor： Chih-Wei FU ,  Chih-Peng LIU ,  Yi-Hsun CHEN ,  Chia-Mu TU ,  Chiu-Lien HUNG

IPC: C07D231/12 ,  C07D403/12 ,  A61P27/06

Abstract: A compound represented by Formula (I), a pharmaceutically acceptable salt or ester, hydrate, solvate or crystalline form thereof is provided: The compound represented by Formula (I) is a β-amino acid derivative, and in Formula (I) X is a single bond or O; Y is NH or C═O; Z is C═O, C═S, NH, W is C or N; A is a single bond, O, OH, OCH2, a heterocycle or N3; R1 is H or F; R2 is H, F, OH, CF3, CH2OH, CHO or R3 is H; n is 0 or 1; and m is 0 or 1.

公开(公告)号：US20220227771A1

公开(公告)日：2022-07-21

申请号：US17561055

申请日：2021-12-23

Applicant: Industrial Technology Research Institute

Inventor： Chih-Wei FU ,  Hao-Hsuan LIU ,  Chiu-Lien HUNG ,  Yu-Chin LIN ,  Tsan-Lin HU ,  Chien-Chin HUANG

IPC: C07D487/04 ,  A61P35/00 ,  C07D417/14 ,  C07D417/12 ,  C07D401/04

Abstract: An androgen receptor (AR) binding molecule has the structure of Formula (I) shown in the following: wherein E and G independently are CH2 or CH, is OH, NH2, OTf or C≡C, X is CF3 or trifluorophenyl, and Y and Z independently are CH2 or CH; or is absent, X is CF3, and Y and Z independently are CH2.