公开(公告)号：US20220227771A1

公开(公告)日：2022-07-21

申请号：US17561055

申请日：2021-12-23

Applicant: Industrial Technology Research Institute

Inventor： Chih-Wei FU ,  Hao-Hsuan LIU ,  Chiu-Lien HUNG ,  Yu-Chin LIN ,  Tsan-Lin HU ,  Chien-Chin HUANG

IPC: C07D487/04 ,  A61P35/00 ,  C07D417/14 ,  C07D417/12 ,  C07D401/04

Abstract: An androgen receptor (AR) binding molecule has the structure of Formula (I) shown in the following: wherein E and G independently are CH2 or CH, is OH, NH2, OTf or C≡C, X is CF3 or trifluorophenyl, and Y and Z independently are CH2 or CH; or is absent, X is CF3, and Y and Z independently are CH2.