公开(公告)号：US09107979B2

公开(公告)日：2015-08-18

申请号：US13870178

申请日：2013-04-25

Applicant: Industrial Technology Research Institute

Inventor： Li-Hsin Lin ,  Hsin-Hsin Shen ,  Ying-Hsueh Chao ,  Hsiu-Hua Huang ,  Yu-Bing Liou ,  Chih-Bing Hung ,  Chin-Fu Chen

IPC: A61K9/00 ,  A61L27/26 ,  A61L27/58 ,  A61L27/54 ,  A61L27/56 ,  A61K9/70

CPC classification number: A61L27/26 ,  A61K9/006 ,  A61K9/70 ,  A61K9/7007 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  C08L67/04 ,  C08L71/02

Abstract: A bioresorbable porous film, including a blend mixture of polylactic acid and at least two kinds of polyethylene glycol, wherein the at least two kinds of polyethylene glycol include a first polyethylene glycol, which is in a solid form under ambient temperature and atmospheric pressure, and a second polyethylene glycol, which is in a liquid form under ambient temperature and atmospheric pressure is provided. The film has a porosity of 10%-90%.

Abstract translation: 一种生物可吸收多孔膜，其包括聚乳酸和至少两种聚乙二醇的混合物，其中所述至少两种聚乙二醇包括在环境温度和大气压下为固体形式的第一聚乙二醇，以及 提供在环境温度和大气压下为液体形式的第二聚乙二醇。 该膜的孔隙率为10％-90％。

公开(公告)号：US10449272B2

公开(公告)日：2019-10-22

申请号：US15294047

申请日：2016-10-14

Applicant: Industrial Technology Research Institute

Inventor： Yu-Chi Wang ,  Hsin-Hsin Shen ,  Chin-Fu Chen ,  Meng-Yow Hsieh ,  Sen-Lu Chen ,  Yu-Bing Liou ,  Tsai-Yu Lin ,  Pei-Shan Li ,  Wei-Lin Yu

IPC: A61L31/04 ,  A61L31/14

Abstract: The present disclosure provides a hydrogel composition including: a hydrogel having a structure represented by Formula (I) or Formula (II) shown as follows: A-B-BOX-B-A, Formula (I); B-A-B-(BOX-BAB)n-BOX-B-A-B, Formula (II), wherein, A is a hydrophilic polyethylene glycol polymer, B is a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2′-Bis(2-oxazoline) for coupling di-block of A-B or tri-block of B-A-B, and n is an integer greater than or equal to 0; and an anti-adhesion additive, wherein the anti-adhesion additive comprises a carbohydrate, a nitrogen-containing cyclic compound, a polymer or a combination thereof.

公开(公告)号：US09084822B2

公开(公告)日：2015-07-21

申请号：US13871491

申请日：2013-04-26

Applicant: Industrial Technology Research Institute

Inventor： Hsin-Hsin Shen ,  Yu-Bing Liou ,  Chin-Fu Chen ,  Li-Hsin Lin ,  Hsiu-Hua Huang ,  Ying-Hsueh Chao ,  Meng-Yow Hsieh ,  Miao-Tzu Chen ,  Chih-Bing Hung

IPC: A61L27/54 ,  A61K47/34 ,  A61K9/00

CPC classification number: A61K47/34 ,  A61K9/0024

Abstract: The disclosure provides a solid form and a method for preparing the same. The solid form consists essentially of a biodegradable copolymer and an amide-containing compound. The biodegradable copolymer is semi-crystalline due to the dipole-dipole interaction between the biodegradable copolymer and the urea. The method for preparing the above solid form includes: dissolving a biodegradable copolymer and an amide-containing compound in water at a first temperature, obtaining a solution; cooling the solution at a second temperature to form a solid mixture; and the solid mixture is subjected to a freeze-drying process at a third temperature.

Abstract translation: 本公开提供了一种固体形式及其制备方法。 固体形式基本上由可生物降解的共聚物和含酰胺的化合物组成。 由于可生物降解的共聚物和尿素之间的偶极 - 偶极相互作用，生物降解性共聚物是半结晶的。 制备上述固体形式的方法包括：在第一温度下将可生物降解的共聚物和含酰胺的化合物溶解在水中，得到溶液; 在第二温度下冷却溶液以形成固体混合物; 并将固体混合物在第三温度下进行冷冻干燥处理。