公开(公告)号：US10449272B2

公开(公告)日：2019-10-22

申请号：US15294047

申请日：2016-10-14

Applicant: Industrial Technology Research Institute

Inventor： Yu-Chi Wang ,  Hsin-Hsin Shen ,  Chin-Fu Chen ,  Meng-Yow Hsieh ,  Sen-Lu Chen ,  Yu-Bing Liou ,  Tsai-Yu Lin ,  Pei-Shan Li ,  Wei-Lin Yu

IPC: A61L31/04 ,  A61L31/14

Abstract: The present disclosure provides a hydrogel composition including: a hydrogel having a structure represented by Formula (I) or Formula (II) shown as follows: A-B-BOX-B-A, Formula (I); B-A-B-(BOX-BAB)n-BOX-B-A-B, Formula (II), wherein, A is a hydrophilic polyethylene glycol polymer, B is a hydrophobic polyester polymer, BOX is a bifunctional group monomer of 2,2′-Bis(2-oxazoline) for coupling di-block of A-B or tri-block of B-A-B, and n is an integer greater than or equal to 0; and an anti-adhesion additive, wherein the anti-adhesion additive comprises a carbohydrate, a nitrogen-containing cyclic compound, a polymer or a combination thereof.