公开(公告)号：US10398647B2

公开(公告)日：2019-09-03

申请号：US15788920

申请日：2017-10-20

Applicant: Industrial Technology Research Institute

Inventor： Wen-Hsuan Chiang ,  Yu-Wen Lo ,  Felice Cheng ,  Maggie Lu ,  Ya-Ling Chiu

IPC: A61K9/06 ,  A61K47/10 ,  A61K47/34 ,  A61K31/704 ,  A61K38/38 ,  A61K38/17 ,  C07K16/32 ,  A61K39/395 ,  A61K38/26 ,  A61K33/30 ,  A61K47/42 ,  A61K39/00 ,  A61K9/00

Abstract: A hydrogel composition is provided. The hydrogel composition includes polyglutamic acid (PGA) containing maleimide groups, and polyethylene glycol (PEG) containing terminal thiol groups, wherein the hydrogel composition has a pH value ranging from 4.0 to 6.5. A drug delivery system is also provided. The drug delivery system includes the above-mentioned hydrogel composition, and a pharmaceutically active ingredient encapsulated in the hydrogel composition.

公开(公告)号：US09408917B2

公开(公告)日：2016-08-09

申请号：US13926363

申请日：2013-06-25

Applicant: Industrial Technology Research Institute

Inventor： Maggie J. M. Lu ,  Yu-Wen Lo ,  Chih-Peng Liu ,  Chia-Wen Huang ,  Shuen-Hsiang Chou ,  Po-Hung Lai ,  Tsan-Lin Hu ,  Min-Ying Lin ,  Chia-Mu Tu

IPC: A61K47/36 ,  A61K9/00 ,  A61K9/127

CPC classification number: A61K47/36 ,  A61K9/0024 ,  A61K9/0085 ,  A61K9/127

Abstract: The disclosure provides a pharmaceutical composition. The pharmaceutical composition includes a chitosan with palmitoyl groups and an active agent. According to another embodiment, the pharmaceutical composition can further include a gelling accelerating agent. According to an embodiment of the disclosure, the active agent of the disclosure can be administered in the form of a nano-drug, liposome, micelle, or microparticle.

Abstract translation: 本公开提供药物组合物。 药物组合物包括具有棕榈酰基团的壳聚糖和活性剂。 根据另一个实施方案，药物组合物可以进一步包括胶凝加速剂。 根据本公开的实施方案，本公开的活性剂可以以纳米药物，脂质体，胶束或微粒的形式施用。