公开(公告)号：US20150017191A1

公开(公告)日：2015-01-15

申请号：US14377488

申请日：2013-02-07

Applicant: Infectious Disease Research Institute

Inventor： Christopher Fox ,  Steven G. Reed ,  Susan Baldwin ,  Thomas Vedvick

IPC: A61K9/113 ,  A61K47/26 ,  A61K47/24 ,  A61K39/00 ,  A61K39/39

Abstract: Formulations and methods, including vaccines and pharmaceutical compositions for inducing or enhancing an immune response are disclosed. The formulations generally comprise a TLR4 agonist and a metabolizable oil at a concentration of about 0.01%-1% v/v, wherein the hydrophobic:lipophilic balance (HLB) of the emulsion is greater than about 9.

Abstract translation: 公开了制剂和方法，包括用于诱导或增强免疫应答的疫苗和药物组合物。 制剂通常包含浓度为约0.01％-1％v / v的TLR4激动剂和可代谢的油，其中乳液的疏水性：亲油平衡（HLB）大于约9。