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公开(公告)号:US20220152116A1
公开(公告)日:2022-05-19
申请号:US17649512
申请日:2022-01-31
发明人: Aleksandr M. Aliper , Aleksandrs Zavoronkovs , Ivan Ozerov , Marine E. Bozdaganyan , Artem V. Artemov
IPC分类号: A61K35/28 , A61K31/195 , A61K38/17 , A61K31/4709 , A61K31/519 , A61K31/506 , A61K31/4439 , A61K31/353 , A61K31/453 , A61K31/416 , A61K31/4412 , A61K31/192 , A61K31/436 , A61K31/12 , A61K45/06 , A61K31/4745 , A61K31/44 , A61K38/16 , A61K31/585 , A61K31/352 , A61K31/196 , A61K35/36 , A61K31/26
摘要: A method of treating senescence in a subject can include applying a senoremediation drug treatment protocol to the subject in order to rescue one or more first cells in the subject, wherein the senoremediation drug treatment protocol is derived from a computational transcriptome analysis of the tissue or organ of the subject. The method can include applying a senolytic drug treatment protocol to the subject in order to remove one or more second cells in the subject. The method can include introducing stem cells into a tissue and/or organ of the subject in order to rejuvenate one or more tissue cells in the tissue and/or one or more organ cells in the organ. The method can include carrying out a reinforcement step that includes one or more actions that prevent further senescence or degradation of the tissue or organ.