公开(公告)号：US10426758B2

公开(公告)日：2019-10-01

申请号：US15768388

申请日：2016-10-13

申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) ,  Centre National de la Recherche Scientifique (CNRS) ,  Universite De Poitiers ,  Sorbonne Universite ,  Universite Claude Bernard Lyon 1

发明人： Marie-Thérèse Dimanche-Boitrel ,  Stéphane Bach ,  Claire Delehouze ,  Yvette Mettey ,  Peter Goekjian ,  Arnaud Comte

IPC分类号： A61K31/437 ,  C07D471/04 ,  A01N1/02 ,  A61P9/10 ,  A61P1/16 ,  A61P1/00

摘要： The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as inhibitor of cellular necroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof, for use for preventing and/or treating disorders associated with cellular necroptosis. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.

公开(公告)号：US20180325876A1

公开(公告)日：2018-11-15

申请号：US15768388

申请日：2016-10-13

申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) ,  Centre National de la Recherche Scientifique (CNRS) ,  Universite De Poitiers ,  Sorbonne Universite ,  Universite Claude Bernard Lyon 1

发明人： Marie-Thérèse Dimanche-Boitrel ,  Stéphane Bach ,  Claire Delehouze ,  Yvette Mettey ,  Peter Goekjian ,  Arnaud Comte

IPC分类号： A61K31/437 ,  A01N1/02 ,  A61P1/16 ,  A61P9/10

CPC分类号： A61K31/437 ,  A01N1/0226 ,  A61P1/00 ,  A61P1/16 ,  A61P9/10 ,  C07D471/04

摘要： The present invention relates to a compound of the following general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof, for use as inhibitor of cellular necroptosis. The present invention also relates to a pharmaceutical composition comprising a compound of general formula (I), or a pharmaceutically acceptable salt and/or solvate thereof, for use for preventing and/or treating disorders associated with cellular necroptosis. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.

公开(公告)号：US20180312502A1

公开(公告)日：2018-11-01

申请号：US15768395

申请日：2016-10-13

申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) ,  Centre National de la Recherche Scientifique (CNRS) ,  Sorbonne Universite ,  Universite Claude Bernard Lyon 1

发明人： Marie-Thérèse Dimanche-Boitrel ,  Stéphane Bach ,  Claire Delehouze ,  Peter Goekjian ,  Arnaud Comte

IPC分类号： C07D471/04

CPC分类号： C07D471/04

摘要： The present invention relates to new N1- and N7-substituted sibiriline derivatives of the following general formula (I): (I) or a pharmaceutically acceptable salt and/or solvate thereof, notably for use as drug, in particular for use as inhibitor of cellular necroptosis. The present invention also relates to a pharmaceutical composition comprising such a compound and processes to prepare such a compound. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.

公开(公告)号：US10457678B2

公开(公告)日：2019-10-29

申请号：US15768395

申请日：2016-10-13

申请人： Institut National de la Sante et de la Recherche Medicale (INSERM) ,  Centre National de la Recherche Scientifique (CNRS) ,  Sorbonne Universite ,  Universite Claude Bernard Lyon 1

发明人： Marie-Thérèse Dimanche-Boitrel ,  Stéphane Bach ,  Claire Delehouze ,  Peter Goekjian ,  Arnaud Comte

IPC分类号： A61K31/437 ,  C07D471/04

摘要： The present invention relates to new N1- and N7-substituted sibiriline derivatives of the following general formula (I): (I) or a pharmaceutically acceptable salt and/or solvate thereof, notably for use as drug, in particular for use as inhibitor of cellular necroptosis. The present invention also relates to a pharmaceutical composition comprising such a compound and processes to prepare such a compound. The present invention also encompasses the use of a compound of the general formula (I) for organs preservation.