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    Recombinant vector for producing and secreting peptide or protein of interest by propionibacteria and applications thereof
    7.
    发明授权
    Recombinant vector for producing and secreting peptide or protein of interest by propionibacteria and applications thereof 有权
    用于通过丙酸杆菌产生和分泌感兴趣的肽或蛋白质的重组载体及其应用

    公开(公告)号：US09476056B2

    公开(公告)日：2016-10-25

    申请号：US13679344

    申请日：2012-11-16

    申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

    发明人： Gwenael Jan ,  Marie-Thérèse Dimanche-Boitrel ,  Hélène Falentin ,  Charles Halouze

    IPC分类号： C12N15/74 ,  C07K14/705

    CPC分类号： C12N15/74 ,  C07K14/70578 ,  C07K2319/02 ,  Y02P20/582

    摘要： The present invention relates to a recombinant vector for expressing and secreting, by a Propionibacterium, at least one eukaryotic peptide or protein of interest, comprising at least: under the control of at least one suitable promoter, at least one nucleic acid sequence encoding a propionibacterial signal peptide and, at least one nucleic acid sequence encoding said eukaryotic peptide or protein of interest; wherein said at least one nucleic acid sequence encoding a propionibacterial signal peptide is translationally fused to said at least one nucleic acid sequence encoding said eukaryotic peptide or protein of interest. The invention further relates to the uses of such a vector in the pharmaceutical field or for the large-scale production of peptides or proteins of interest.

    摘要翻译： 本发明涉及用于由丙酸杆菌表达和分泌至少一种感兴趣的真核肽或蛋白质的重组载体，其至少包含：至少一种合适的启动子控制的至少一种编码丙酸杆菌的核酸序列 信号肽和至少一个编码目的的真核肽或蛋白质的核酸序列; 其中所述至少一种编码丙型肝炎信号肽的核酸序列与所述至少一种编码所述真核肽或目的蛋白的核酸序列融合。 本发明还涉及这种载体在制药领域中的用途或用于大规模生产感兴趣的肽或蛋白质。