公开(公告)号：US11414460B2

公开(公告)日：2022-08-16

申请号：US16933679

申请日：2020-07-20

申请人： Institute for Systems Biology

发明人： James R. Heath

IPC分类号： A61K38/00 ,  C07K7/50

摘要： Disclosed are compounds, compositions, and methods involving cyclic peptides that can bind to KRAS (G12D) oncogenic protein. For example, disclosed are cyclic peptides that selectively bind KRAS (G12D) oncogenic protein. Also disclosed are methods of inhibiting KRAS (G12D) oncogenic protein in a cancer cell expressing KRAS (G12D) oncogenic protein. In some forms, the method comprises incubating the cancer cell with any one or more of the disclosed cyclic peptides. In some forms, the method comprises bringing into contact the cancer cell with any one or more of the disclosed cyclic peptides.

公开(公告)号：US20210032293A1

公开(公告)日：2021-02-04

申请号：US16933679

申请日：2020-07-20

申请人： Institute for Systems Biology

发明人： James R. Heath

IPC分类号： C07K7/50

摘要： Disclosed are compounds, compositions, and methods involving cyclic peptides that can bind to KRAS (G12D) oncogenic protein. For example, disclosed are cyclic peptides that selectively bind KRAS (G12D) oncogenic protein. Also disclosed are methods of inhibiting KRAS (G12D) oncogenic protein in a cancer cell expressing KRAS (G12D) oncogenic protein. In some forms, the method comprises incubating the cancer cell with any one or more of the disclosed cyclic peptides. In some forms, the method comprises bringing into contact the cancer cell with any one or more of the disclosed cyclic peptides.

公开(公告)号：US20220402971A1

公开(公告)日：2022-12-22

申请号：US17815805

申请日：2022-07-28

申请人： Institute for Systems Biology

发明人： James R. Heath

IPC分类号： C07K7/50

摘要： Disclosed are compounds, compositions, and methods involving cyclic peptides that can bind to KRAS (G12D) oncogenic protein. For example, disclosed are cyclic peptides that selectively bind KRAS (G12D) oncogenic protein. Also disclosed are methods of inhibiting KRAS (G12D) oncogenic protein in a cancer cell expressing KRAS (G12D) oncogenic protein. In some forms, the method comprises incubating the cancer cell with any one or more of the disclosed cyclic peptides. In some forms, the method comprises bringing into contact the cancer cell with any one or more of the disclosed cyclic peptides.

公开(公告)号：US20230076204A1

公开(公告)日：2023-03-09

申请号：US17800311

申请日：2021-02-18

申请人： Institute for Systems Biology ,  California Institute of Technology

发明人： James R. Heath ,  William Chour ,  Rongyu Zhang

IPC分类号： C07K14/74 ,  C12N15/79 ,  C40B40/08 ,  C40B40/10 ,  G01N33/569

摘要： Peptide-major histocompatibility (MHC) Class II nucleic acids and proteins are provided. Methods of their use, for example in methods of identifying antigen-specific T cells and adoptive cell therapy, are also provided.

公开(公告)号：US20210380640A1

公开(公告)日：2021-12-09

申请号：US17336276

申请日：2021-06-01

申请人： Institute for Systems Biology

发明人： James R. Heath ,  Matthew Idso

IPC分类号： C07K7/08 ,  C07K7/06 ,  A61K47/64 ,  A61K47/55

摘要： Disclosed are compounds, compositions, and methods relating to epitope-targeted immunostimulants (EPIs), which comprise a synthetic peptide ligand and an antibody-recruiting moiety. The peptide ligand binds an epitope on a target and the antibody-recruiting moiety recruits antibodies to the target when the EPI is bound to the epitope on the target. Also disclosed are compositions comprising any of the disclosed EPIs. Also disclosed are methods of stimulating an immune reaction to a microorganism or other pathogen in a subject where an EPI is administered to the subject. Also disclosed are methods of identifying the peptide ligand by using multi-omic analysis.

公开(公告)号：US20200323973A1

公开(公告)日：2020-10-15

申请号：US16841635

申请日：2020-04-06

申请人： Institute for Systems Biology

发明人： James R. Heath ,  Matthew N. Idso ,  Mario Arrieta-Ortiz ,  Ajay Akhade

IPC分类号： A61K39/085 ,  A61K39/108 ,  G01N33/68

摘要： Disclosed are compounds, compositions, and methods relating to epitope-targeted immunostimulants (EPIs), which comprise a synthetic peptide ligand and an antibody-recruiting moiety. The peptide ligand binds an epitope on a target and the antibody-recruiting moiety recruits antibodies to the target when the EPI is bound to the epitope on the target. Also disclosed are compositions comprising any of the disclosed EPIs. Also disclosed are methods of stimulating an immune reaction to a microorganism or other pathogen in a subject where an EPI is administered to the subject. Also disclosed are methods of identifying the peptide ligand by using multi-omic analysis.