-
1.
公开(公告)号:US11123452B2
公开(公告)日:2021-09-21
申请号:US16662774
申请日:2019-10-24
申请人: Institute of Medical Support Technology, Academy of System Engineering, Academy of Military Science
发明人: Jing Guan , Jian Yang , Ying Zhang , Feng Tian , Jimin Wu , Sheng Ding , Zhihong Li , Chunlai Wang
摘要: The present invention relates to an alkyl chitosan-graphene oxide composite sponge and preparation method and application thereof. The alkyl chitosan-graphene oxide composite sponge provided by the present invention includes alkyl chitosan and graphene oxide absorbed on the alkyl chitosan, and the adsorbing capacity of the graphene oxide is 3-28 wt. %. In the present invention, alkyl chitosan is used as a matrix to combine graphene oxide and alkyl chitosan; the obtained composite sponge has excellent hemostatic performance and blood absorption capacity. Results of embodiments indicate that the in-vitro whole blood coagulation time is less than 58 s, the hemostasis time of a rabbit femoral artery hemorrhage model is less than 155 s, the hemorrhage mass is less than 5.4 g, and the hemostatic effect is superior to a pure alkyl chitosan sponge or graphene oxide powder when the composite sponge provided by the present invention is used for hemostasis.