公开(公告)号：US10175190B2

公开(公告)日：2019-01-08

申请号：US15144591

申请日：2016-05-02

Applicant: Intel Corporation

Inventor： Noureddine Tayebi ,  Xing Su ,  Handong Li

IPC: G01N27/327 ,  C23C16/00

Abstract: Highly selective coated-electrode nanogap transducers for the detection of redox molecules are described. In an example, an analyte detection system includes one or more transducer electrodes having a surface for analyte detection. The surface includes a coating to inhibit direct contact of analyte with the surface of the one or more transducer electrodes.

公开(公告)号：US09464109B2

公开(公告)日：2016-10-11

申请号：US14501764

申请日：2014-09-30

Applicant: Intel Corporation

Inventor： Handong Li ,  Narayan Sundararajan

IPC: C07K1/13 ,  C07K7/08

CPC classification number: C07K1/13 ,  C07K7/08

Abstract: A method for the introduction of a labeling structure such as fluorescent molecules or a Raman tag to a compound is described. Imidazole functionalized resins or polymers are used to selectively immobilize phosphocompounds without protecting the carboxylic groups is described. Relying on the pKa difference between amines and hydrazides and carrying out the reaction in a slightly acidic buffer, all of the amines are protected by protonation while the hydrazides react with the phosphate imidazolide to form a phosphoramidate bond.

Abstract translation: 描述了向化合物引入诸如荧光分子或拉曼标签的标记结构的方法。 使用咪唑官能化树脂或聚合物来选择性地固定磷酸化合物而不保护羧基。 依赖于胺和酰肼之间的pKα差异并在微酸性缓冲液中进行反应，所有的胺都被质子化保护，而酰肼与磷酸咪唑化物反应形成氨基磷酸酯键。