公开(公告)号：US12023374B2

公开(公告)日：2024-07-02

申请号：US17294706

申请日：2019-11-22

申请人： Intervet Inc.

发明人： Theodora Johanna Van Kasteren-Westerneng ,  Antonius Arnoldus Christiaan Jacobs

IPC分类号： A61K39/12 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61K2039/545 ,  A61K2039/55

摘要： The present invention pertains to a vaccine comprising an IgM protease antigen of Streptococcus suis, for use in a method for protecting a pig against Streptococcus suis, characterised in that the IgM protease antigen is a protein according to SEQ ID NO:1.

公开(公告)号：US20220378899A1

公开(公告)日：2022-12-01

申请号：US17775425

申请日：2020-11-19

申请人： Intervet Inc.

发明人： Antonius Arnoldus Christiaan Jacobs ,  Theodora Johanna Van Kasteren-Westerneng ,  Johanna Jacoba Elisabeth Bijlsma

IPC分类号： A61K39/102 ,  A61P31/04

摘要： The invention pertains to a protein having at least 69% sequence identity with the protein according to SEQ ID No: 1 or an immunogenic fragment of this protein, for use in a prophylactic method to protect a pig against an infection with Haemophilus parasuis serotype 4 and an infection with Haemophilus parasuis serotype 5, by administering a vaccine to the pig, the vaccine comprising the protein or the immunogenic fragment thereof as an antigen. The invention also pertains to a vaccine, a method to manufacture such a vaccine and a method to protect a pig against H. parasuis.

公开(公告)号：US20220387577A1

公开(公告)日：2022-12-08

申请号：US17775411

申请日：2020-11-19

申请人： Intervet Inc.

发明人： Antonius Arnoldus Christiaan Jacobs ,  Theodora Johanna Van Kasteren-Westerneng ,  Johanna Jacoba Elisabeth Bijlsma

IPC分类号： A61K39/102 ,  A61P31/04

摘要： The invention pertains to a serine protease antigen which induces antibodies against a protein having at least 69% sequence identity with the Heamophilus parasuis protein according to SEQ ID No: 1, for use in a prophylactic method to protect a pig against an infection with Haemophilus parasuis by administering a vaccine to the pig, wherein the vaccine comprises the serine protease antigen. The invention also pertains to a vaccine, a method to manufacture such a vaccine and a method to protect a pig against H. parasuis.

公开(公告)号：US20220378900A1

公开(公告)日：2022-12-01

申请号：US17775428

申请日：2020-11-19

申请人： Intervet Inc.

发明人： Antonius Arnoldus Christiaan Jacobs ,  Theodora Johanna Van Kasteren-Westerneng ,  Johanna Jacoba Elisabeth Bijlsma

IPC分类号： A61K39/102 ,  A61P31/04

摘要： The invention pertains to a protein having at least 69% sequence identity with the protein according to SEQ ID No: 1 or an immunogenic fragment of this protein, for use in a prophylactic method to protect a pig against an infection with Haemophilus parasuis by administering a vaccine to the pig, the vaccine comprising the protein or the immunogenic fragment thereof as an antigen. The invention also pertains to a vaccine, a method to manufacture such a vaccine and a method to protect a pig against H. parasuis.