公开(公告)号：US12214027B2

公开(公告)日：2025-02-04

申请号：US17441768

申请日：2020-03-27

Applicant: Intervet inc.

Inventor： Martin Piest ,  Edwin Kets ,  Paul Vermeij ,  Marian Anna Catharina Jozefina Heijnen ,  Nöel Dautzenberg

IPC: A61K39/02 ,  A61K39/00

Abstract: The present invention relates to a liquid composition of live Mollicutes bacteria and a stabiliser, whereby the stabiliser is a natural deep-eutectic solvent (NADES). In this liquid composition the live Mollicutes are stabilised without need for freezing or freeze-drying. This allows various advantageous uses in diagnostics and medicine, specifically as a liquid vaccine for use against infection or disease caused by Mollicutes bacteria, for human- or non-human animals.

公开(公告)号：US12180288B2

公开(公告)日：2024-12-31

申请号：US17081188

申请日：2020-10-27

Applicant: Intervet Inc.

Inventor： Mohamad Morsey ,  Yuanzheng Zhang

IPC: C07K16/28

Abstract: The present invention discloses antibodies and blocking antibodies to canine IL-4 receptor alpha that have specific sequences and a high binding affinity for canine IL-4 receptor α. The present invention also discloses the use of the antibodies of the present invention in the treatment of atopic dermatitis in dogs. The present invention further discloses unique epitopes that bind to the antibodies to canine IL-4 receptor alpha.

公开(公告)号：US20240382579A1

公开(公告)日：2024-11-21

申请号：US18683835

申请日：2022-08-19

Applicant: Intervet Inc.

Inventor： Erwin Van Den Born ,  Carina Leifeld ,  Amaya Serrano Garcia ,  Holger Honemann ,  Alexandra Jimenez Melsio ,  Kimberly Pietersz

IPC: A61K39/135 ,  A61K39/00 ,  A61P37/04 ,  C07K14/005 ,  C12N15/86

Abstract: The invention concerns a method of producing a foot and mouth disease virus (FMDV) virus-like particle (VLP) in a baculovirus expression system, the method comprising the steps of (i) infecting an insect cell with a baculovirus expression vector, (ii) culturing the insect cell in cell culture medium for 4 days or more post infection, (iii) separating the insect cells from the cell culture to obtain cell-free cell culture medium, and (iv) harvesting the FMDV VLP from the cell-free cell culture medium. The invention further relates to a vaccine for use in the protection of a subject against an infection with FMDV, the vaccine being obtainable by the method of the invention.

公开(公告)号：US20240358816A1

公开(公告)日：2024-10-31

申请号：US18684529

申请日：2022-06-29

Applicant: Intervet Inc. ,  The Pirbright Institute

Inventor： Erwin Van Den Born ,  Ian Jones

IPC: A61K39/135 ,  A61K39/00 ,  A61P37/04 ,  C07K14/005 ,  C12N15/86

CPC classification number: A61K39/135 ,  A61P37/04 ,  C07K14/005 ,  C12N15/86 ,  A61K2039/5258 ,  C12N2710/14044 ,  C12N2770/32122 ,  C12N2770/32123 ,  C12N2770/32134 ,  C12N2770/32152 ,  C12N2770/32171

Abstract: The present invention provides a recombinant foot and mouth disease virus (FMDV) capsid precursor protein comprising a modified VP1 protein and optionally further comprising a modified VP4 protein. The invention further relates to an isolated nucleic acid molecule and an expression vector comprising the nucleic acid molecule for recombinant expression of the modified capsid precursor protein. In further aspects, the invention relates to a virus-like particle (VLP) obtained from the modified capsid precursor protein and a vaccine for use in the protection of a subject against an infection with FMDV produced from the VLP.

公开(公告)号：US12128032B2

公开(公告)日：2024-10-29

申请号：US17653950

申请日：2022-03-08

Applicant: Intervet Inc.

Inventor： Anja Regina Heckeroth ,  Hartmut Zoller ,  Annie Flochlay-Sigognault ,  Bruno Huyghe

IPC: A01N43/80 ,  A01N43/90 ,  A61K9/00 ,  A61K9/08 ,  A61K31/42 ,  A61K31/422 ,  A61K31/437 ,  A61K47/10 ,  A61K47/26

CPC classification number: A61K31/42 ,  A01N43/80 ,  A01N43/90 ,  A61K9/0053 ,  A61K9/08 ,  A61K31/422 ,  A61K31/437 ,  A61K47/10 ,  A61K47/26

Abstract: The present invention relates to methods of treating or preventing arthropod infestations of poultry animals and methods of controlling arthropod infestations in poultry animal's environment by administering an isoxazoline compound of formula (I)




via drinking water.

公开(公告)号：US20240342204A1

公开(公告)日：2024-10-17

申请号：US18294592

申请日：2022-08-05

Applicant: Intervet Inc.

Inventor： Edward Murray ,  Ralf Warrass ,  Joachim Ullrich ,  Basav Hangalapura Nagaraj ,  Willem Huisman

IPC: A61K31/7068 ,  A61P31/14 ,  A61P31/16 ,  A61P37/04

CPC classification number: A61K31/7068 ,  A61P31/14 ,  A61P31/16 ,  A61P37/04

Abstract: A method of preventing or treating a viral disease in an animal comprising administering to the animal a pharmaceutical composition comprising an antiviral nucleoside β-D-N(4)-hydroxycytidine (NHC) or a prodrug or salt thereof and a pharmaceutically acceptable carrier and wherein the viral disease is Porcine Reproductive and Respiratory Syndrome (PRRS), Bovine Respiratory Disease (BRD), Equine Influenza, Canine Distemper, Canine Respiratory Disease, Feline Infectious Peritonitis, Feline Viral Rhinotracheitis, or Feline Immunodeficiency.

公开(公告)号：US20240325514A1

公开(公告)日：2024-10-03

申请号：US18293380

申请日：2022-06-29

Applicant: Intervet Inc.

Inventor： Antonius Arnoldus Christiaan Jacobs

IPC: A61K39/09 ,  A61K39/00 ,  A61P37/04

CPC classification number: A61K39/092 ,  A61P37/04 ,  A61K2039/552

Abstract: The present invention pertains to a vaccine for protection against a pathogenic infection with Streptococcus suis, the vaccine comprising a whole IgM protease antigen of Streptococcus suis, the antigen comprising in its amino acid sequence less than four repeats, and a pharmaceutically acceptable carrier. The invention also pertains to this antigen for use in a method to protect a pig against such an infection, and to a method to protect such a pig.

公开(公告)号：US12077514B2

公开(公告)日：2024-09-03

申请号：US17414214

申请日：2019-12-20

Applicant: Intervet Inc.

Inventor： Harald Schmitt

IPC: C07D261/04 ,  C07B55/00

CPC classification number: C07D261/04 ,  C07B55/00

Abstract: The present invention relates to a method for racemizing (5R)-4-[5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4H-isoxazol-3-yl]-2-methyl-benzoic acid.

公开(公告)号：US12023374B2

公开(公告)日：2024-07-02

申请号：US17294706

申请日：2019-11-22

Applicant: Intervet Inc.

Inventor： Theodora Johanna Van Kasteren-Westerneng ,  Antonius Arnoldus Christiaan Jacobs

IPC: A61K39/12 ,  A61K39/00

CPC classification number: A61K39/12 ,  A61K2039/545 ,  A61K2039/55

Abstract: The present invention pertains to a vaccine comprising an IgM protease antigen of Streptococcus suis, for use in a method for protecting a pig against Streptococcus suis, characterised in that the IgM protease antigen is a protein according to SEQ ID NO:1.

公开(公告)号：US20240197851A1

公开(公告)日：2024-06-20

申请号：US17909917

申请日：2021-03-12

Applicant: Intervet Inc.

Inventor： Antonius Arnoldus Christiaan Jacobs

IPC: A61K39/09 ,  A61K39/00 ,  A61P31/04 ,  A61P37/04

CPC classification number: A61K39/092 ,  A61P31/04 ,  A61P37/04 ,  A61K2039/552 ,  A61K2039/70

Abstract: The present invention pertains to a vaccine comprising in combination an IgM protease antigen of Streptococcus suis and a Streptococcus suis bacterin of serotype (9), sequence type (16), for use in a method for protecting pigs against a pathogenic infection with Streptococcus suis serotype (9), sequence type (16).