公开(公告)号：US20170342440A1

公开(公告)日：2017-11-30

申请号：US15618764

申请日：2017-06-09

Applicant: Intrexon Corporation

Inventor： Subba Reddy PALLI ,  Mohan Basavaraju KUMAR

IPC: C12N15/85 ,  C12N15/63 ,  A61K31/47 ,  A61K31/16 ,  C07H21/04 ,  C07D215/44 ,  C07K14/435 ,  C12N15/62

CPC classification number: C12N15/85 ,  A61K31/16 ,  A61K31/47 ,  C07D215/44 ,  C07H21/04 ,  C07K14/43536 ,  C12N15/62 ,  C12N15/63 ,  C12N15/635 ,  Y10S530/858

Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.

公开(公告)号：US20140322812A1

公开(公告)日：2014-10-30

申请号：US14260801

申请日：2014-04-24

Applicant: Intrexon Corporation

Inventor： Subba Reddy PALLI ,  Mohan Basavaraju KUMAR

IPC: C12N15/85 ,  C12N15/63

CPC classification number: C12N15/85 ,  A61K31/16 ,  A61K31/47 ,  C07D215/44 ,  C07H21/04 ,  C07K14/43536 ,  C12N15/62 ,  C12N15/63 ,  C12N15/635 ,  Y10S530/858

Abstract: This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.

Abstract translation: 本发明涉及生物技术或遗传工程领域。 具体地，本发明涉及基因表达领域。 更具体地，本发明涉及新的取代突变体受体及其在基于核受体的诱导型基因表达系统中的用途以及调节宿主细胞中基因表达的方法，用于诸如基因治疗，大规模生产蛋白质和 抗体，基于细胞的高通量筛选测定，功能基因组学和转基因生物体中性状的调节。