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    Novel Substitution Mutant Receptors and Their Use in an Ecdysone Receptor-Based Inducible Gene Expression System
    2.
    发明申请
    Novel Substitution Mutant Receptors and Their Use in an Ecdysone Receptor-Based Inducible Gene Expression System 审中-公开
    新型替代突变体受体及其在蜕皮激素受体诱导型基因表达系统中的应用

    公开(公告)号：US20170015728A1

    公开(公告)日：2017-01-19

    申请号：US14972901

    申请日：2015-12-17

    申请人： Intrexon Corporation

    发明人： Subba Reddy PALLI ,  Marianna Zinovievna Kapitskaya

    IPC分类号： C07K14/705 ,  C12N15/63

    CPC分类号： C07K14/70567 ,  C07K14/721 ,  C12N15/63

    摘要： This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel nuclear receptors comprising a substitution mutation and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene within a host cell using this inducible gene expression system.

    摘要翻译： 本发明涉及生物技术或遗传工程领域。 具体地，本发明涉及基因表达领域。 更具体地，本发明涉及包含取代突变的新型核受体及其在基于核受体的诱导型基因表达系统中的用途以及使用该诱导型基因表达系统调节宿主细胞内基因表达的方法。

    Mutant Receptors and Their Use in a Nuclear Receptor-Based Inducible Gene Expression System
    5.
    发明申请
    Mutant Receptors and Their Use in a Nuclear Receptor-Based Inducible Gene Expression System 审中-公开
    突变受体及其在基于核受体的诱导基因表达系统中的应用

    公开(公告)号：US20140322812A1

    公开(公告)日：2014-10-30

    申请号：US14260801

    申请日：2014-04-24

    申请人： Intrexon Corporation

    发明人： Subba Reddy PALLI ,  Mohan Basavaraju KUMAR

    IPC分类号： C12N15/85 ,  C12N15/63

    CPC分类号： C12N15/85 ,  A61K31/16 ,  A61K31/47 ,  C07D215/44 ,  C07H21/04 ,  C07K14/43536 ,  C12N15/62 ,  C12N15/63 ,  C12N15/635 ,  Y10S530/858

    摘要： This invention relates to the field of biotechnology or genetic engineering. Specifically, this invention relates to the field of gene expression. More specifically, this invention relates to novel substitution mutant receptors and their use in a nuclear receptor-based inducible gene expression system and methods of modulating the expression of a gene in a host cell for applications such as gene therapy, large scale production of proteins and antibodies, cell-based high throughput screening assays, functional genomics and regulation of traits in transgenic organisms.

    摘要翻译： 本发明涉及生物技术或遗传工程领域。 具体地，本发明涉及基因表达领域。 更具体地，本发明涉及新的取代突变体受体及其在基于核受体的诱导型基因表达系统中的用途以及调节宿主细胞中基因表达的方法，用于诸如基因治疗，大规模生产蛋白质和 抗体，基于细胞的高通量筛选测定，功能基因组学和转基因生物体中性状的调节。