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公开(公告)号：US07713548B2
公开(公告)日：2010-05-11
申请号：US12029691
申请日：2008-02-12
申请人： Irwin C. Jacobs , John D. Higgins , Micael Guillot , Nancy M. Franson , William L. Rocco , Khawla Abdullah Abu-Izza
发明人： Irwin C. Jacobs , John D. Higgins , Micael Guillot , Nancy M. Franson , William L. Rocco , Khawla Abdullah Abu-Izza
IPC分类号： A61K31/503 , A61K9/20
CPC分类号： A61K9/146 , A61K9/2054 , A61K9/2059 , A61K9/4866 , A61K31/5025
摘要： Disclosed are amorphous solid dispersion formulations comprising 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide.
摘要翻译： 公开了包含7-氯-N，N，5-三甲基-4-氧代-3-苯基-3,5-二氢-4H-哒嗪并[4,5-b]吲哚-1-乙酰胺的无定形固体分散体制剂。
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公开(公告)号：US20080160080A1
公开(公告)日：2008-07-03
申请号：US12029691
申请日：2008-02-12
申请人： Irwin C. Jacobs , John D. Higgins , Micael Guillot , Nancy M. Franson , William L. Rocco , Khawla Abdullah Abu-Izza
发明人： Irwin C. Jacobs , John D. Higgins , Micael Guillot , Nancy M. Franson , William L. Rocco , Khawla Abdullah Abu-Izza
IPC分类号： A61K31/503 , A61K9/20
CPC分类号： A61K9/146 , A61K9/2054 , A61K9/2059 , A61K9/4866 , A61K31/5025
摘要： Disclosed are amorphous solid dispersion formulations comprising 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide.
摘要翻译： 公开了包含7-氯-N，N，5-三甲基-4-氧代-3-苯基-3,5-二氢-4H-哒嗪并[4,5-b]吲哚-1-乙酰胺的无定形固体分散体制剂。
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公开(公告)号：US06416793B1
公开(公告)日：2002-07-09
申请号：US09614007
申请日：2000-07-11
申请人： Michael A. Zeligs , Irwin C. Jacobs
发明人： Michael A. Zeligs , Irwin C. Jacobs
IPC分类号： A61K3578
CPC分类号： A61K9/5036 , A61K9/5057 , A61K31/475 , A61K31/55
摘要： The present invention relates to spray dried hydrophobic phytochemical (i.e., yohimbine and ibogaine) compositions, a process for making such compositions and a method of using such compositions for, e.g., the promotion of weight loss. Typically, the hydrophobic dietary compositions of the present invention exhibit enhanced absorptivity when taken orally.
摘要翻译： 本发明涉及喷雾干燥的疏水植物化学（即育亨宾和伊泊加因）组合物，制备这种组合物的方法和使用这种组合物的方法，例如促进体重减轻。 通常，当口服时，本发明的疏水性膳食组合物表现出增强的吸收性。
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公开(公告)号：US20220096369A1
公开(公告)日：2022-03-31
申请号：US17486123
申请日：2021-09-27
申请人： Irwin C. Jacobs
发明人： Irwin C. Jacobs
摘要： The present disclosure is related to transdermal cannabinoid compositions and methods of use thereof.
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公开(公告)号：US20130330408A1
公开(公告)日：2013-12-12
申请号：US14000902
申请日：2012-03-16
申请人： Irwin C. Jacobs
发明人： Irwin C. Jacobs
IPC分类号： A61K9/16 , A61K31/122
CPC分类号： A61K31/122 , A61K9/107 , A61K9/16 , A61K9/1617 , A61K9/1652
摘要： The present invention generally relates to improvements in the bioavailability and/or solubility of coenzyme Q10. For example, the present invention relates to methods for preparing particulate compositions including coenzyme Q10 that generally comprise dispersing and/or dissolving the coenzyme Q10 throughout a suitable solvent, and combining the coenzyme Q10 and an encapsulating (e.g., microencapsulating) agent. The present invention also generally relates to particulate compositions comprising coenzyme Q10 that exhibit improved bioavailability and/or solubility as compared to previous coenzyme Q10 products.
摘要翻译： 本发明一般涉及辅酶Q10的生物利用度和/或溶解度的改善。 例如，本发明涉及用于制备包括辅酶Q10的颗粒组合物的方法，其通常包括将辅酶Q10分散和/或溶解在整个合适的溶剂中，以及将辅酶Q10和包封（例如微胶囊化）试剂混合。 本发明还通常涉及包含与先前的辅酶Q10产物相比显示出改善的生物利用度和/或溶解度的辅酶Q10的颗粒组合物。
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6.发明授权Compositions and methods of adjusting steroid hormone metabolism through phytochemicals 失效通过植物化学调节类固醇激素代谢的组成和方法
公开(公告)号：US6086915A
公开(公告)日：2000-07-11
申请号：US53180
申请日：1998-04-01
申请人： Michael A. Zeligs , Irwin C. Jacobs
发明人： Michael A. Zeligs , Irwin C. Jacobs
IPC分类号： A61K9/16 , A61K36/752 , A61K9/66
CPC分类号： A61K9/1617 , A61K9/1652
摘要： The present invention relates to spray dried hydrophobic phytochemical chemopreventative compositions, a process for making such compositions and a method of using such compositions to adjust steroid metabolism in mammals. Typically, the hydrophobic dietary compositions of the present invention exhibit enhanced absorptivity when taken orally as a chemopreventative agent.
摘要翻译： 本发明涉及喷雾干燥的疏水性植物化学化学预防组合物，制备这种组合物的方法和使用这些组合物调节哺乳动物中类固醇代谢的方法。 通常，当作为化学预防剂口服时，本发明的疏水性膳食组合物表现出增强的吸收性。
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公开(公告)号：US09655849B2
公开(公告)日：2017-05-23
申请号：US14000902
申请日：2012-03-16
申请人： Irwin C. Jacobs
发明人： Irwin C. Jacobs
IPC分类号： A61K9/16 , A61K31/122 , A61K9/107
CPC分类号： A61K31/122 , A61K9/107 , A61K9/16 , A61K9/1617 , A61K9/1652
摘要： The present invention generally relates to improvements in the bioavailability and/or solubility of coenzyme Q10. For example, the present invention relates to methods for preparing particulate compositions including coenzyme Q10 that generally comprise dispersing and/or dissolving the coenzyme Q10 throughout a suitable solvent, and combining the coenzyme Q10 and an encapsulating (e.g., microencapsulating) agent. The present invention also generally relates to particulate compositions comprising coenzyme Q10 that exhibit improved bioavailability and/or solubility as compared to previous coenzyme Q10 products.
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公开(公告)号：US06544552B2
公开(公告)日：2003-04-08
申请号：US09757426
申请日：2001-01-11
IPC分类号： A61K920
CPC分类号： A61K9/0056 , A61K9/2095 , Y10S514/951 , Y10S514/96
摘要： A method of producing a fast-dissolving pharmaceutical delivery device of moderate strength. The delivery device is a fully formed tablet composed of readily available sugars, strength polymers and a volatilizable excipient along with an active ingredient and optional flavorings. The tablet as made will disintegrate in an aqueous medium such as saliva in under 15 seconds, making mastication unnecessary or at least requiring only one or two bites on the tablet. Essential to the invention is the easily obtainable particle size ranges of the sugars and the volatilizable excipient which promotes optimum release and tablet strength. The invention also allows for effective taste masking of the active ingredient with standard particle coating techniques.
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公开(公告)号：US5336433A
公开(公告)日：1994-08-09
申请号：US891735
申请日：1992-06-08
申请人： Hans Lagnemo , Robert E. Sparks , Irwin C. Jacobs
发明人： Hans Lagnemo , Robert E. Sparks , Irwin C. Jacobs
CPC分类号： C11D17/0039 , C01B15/005 , C01B15/106 , C11D3/3942 , Y10T428/2991
摘要： The present invention relates to particles having a core comprising a peroxy compound and a hydrophobic coating comprising:(a) a hydrophobic substance selected from saturated fats, waxes or phosphatides;(b) a surfactant dissolved in the hydrophobic substance;(c) water swellable grains;the hydrophobic substance and the surfactant being substantially inert in respect of the peroxy compound.The invention also relates to preparation and use of the particles. Further, the invention relates to a composition containing such coated particles.
摘要翻译： 本发明涉及具有包含过氧化合物和疏水涂层的芯的颗粒，其包含：（a）选自饱和脂肪，蜡或磷脂的疏水性物质; （b）表面活性剂溶于疏水物质中; （c）水可溶胀颗粒; 疏水性物质和表面活性剂相对于过氧化合物基本上是惰性的。 本发明还涉及颗粒的制备和使用。 此外，本发明涉及包含这种涂覆颗粒的组合物。
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公开(公告)号：US5130473A
公开(公告)日：1992-07-14
申请号：US638268
申请日：1991-01-07
IPC分类号： C09K8/524
CPC分类号： C09K8/524
摘要： Reduction of asphaltene precipitation in asphaltenic subterranean reservoirs treated with aqueous solutions of strong acid is achieved by utilizing novel dithiocarbamate compositions to sequester iron.
摘要翻译： 通过使用新的二硫代氨基甲酸盐组合物螯合铁来实现用强酸水溶液处理的沥青质地下储层中沥青质沉淀的降低。
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