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36 条记录 (耗时 0.037 秒)

    Methods of Manipulating the Fate of Cells
    1.
    发明申请
    Methods of Manipulating the Fate of Cells 审中-公开

    公开(公告)号：US20190169612A1

    公开(公告)日：2019-06-06

    申请号：US16031529

    申请日：2018-07-10

    申请人： Ivan Bergstein

    发明人： Ivan Bergstein

    IPC分类号： C12N15/113 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  C12N15/11 ,  C12Q1/6886 ,  A61K45/06

    摘要： A method of manipulating the fate of a cell, which comprises contacting the cell with at least one of (a) a cell fate-determining untranslated/noncoding RNA species (cuR), (b) a modified cuR, or (c) a compound that modifies or affects cuR, under conditions sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained. Another aspect of the invention relates to a method of manipulating the fate of a cell by contacting the cell with a compound that affects a fate-determining mechanism involving homologous nucleic acid interactions of RNA:RNA or RNA:DNA or resolution of such interactions under conditions sufficient to cause a cell-changing or cell-maintaining fate that results in cell regeneration, cell differentiation or cell death, so that an increase of desirable cells or a decrease in undesirable cells can be obtained. The invention generates cell fate or cell maintenance in a subject, such as a human, so that an increase of desirable cells or a decrease in undesirable cells can be obtained in the subject. This feature can be applied to a therapeutic method of treating a condition in a subject.

    Methods of cancer diagnosis and therapy targeted against a cancer stem line
    9.
    发明授权
    Methods of cancer diagnosis and therapy targeted against a cancer stem line 有权
    针对癌症干线的癌症诊断和治疗方法

    公开(公告)号：US07427400B2

    公开(公告)日：2008-09-23

    申请号：US11583857

    申请日：2006-10-18

    申请人： Ivan Bergstein

    发明人： Ivan Bergstein

    IPC分类号： A61K39/395

    CPC分类号： C07K16/30 ,  A61K31/7088 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/77 ,  G01N33/5017 ,  G01N33/574

    摘要： Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous cancer therapeutic methods because they provide for very early cancer treatment and reduce the likelihood of clinical relapse after treatment.

    摘要翻译： 提供了改进的用于治疗癌症的方法，其涉及缓慢生长，相对突变的癌症干线的靶向。 这些方法是对以前的癌症治疗方法的改进，因为它们提供非常早期的癌症治疗并降低治疗后临床复发的可能性。

    Novel methods of cancer therapy targeted against a cancer stemline
    10.
    发明申请
    Novel methods of cancer therapy targeted against a cancer stemline 有权
    针对癌症干细胞的新型癌症治疗方法

    公开(公告)号：US20060083682A1

    公开(公告)日：2006-04-20

    申请号：US11271381

    申请日：2005-11-10

    申请人： Ivan Bergstein

    发明人： Ivan Bergstein

    IPC分类号： A61K51/00 ,  A61K39/395

    CPC分类号： C07K16/30 ,  A61K31/7088 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/77 ,  G01N33/5017 ,  G01N33/574

    摘要： Improved methods for treatment of cancer which involve the targeting of slow-growing, relatively mutationally-spared cancer stem line are provided. These methods are an improvement over previous cancer therapeutic methods because they provide for very early cancer treatment and reduce the likelihood of clinical relapse after treatment.

    摘要翻译： 提供了改进的用于治疗癌症的方法，其涉及缓慢生长，相对突变的癌症干线的靶向。 这些方法是对以前的癌症治疗方法的改进，因为它们提供非常早期的癌症治疗并降低治疗后临床复发的可能性。