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公开(公告)号:US20060177837A1
公开(公告)日:2006-08-10
申请号:US11204186
申请日:2005-08-15
申请人: Ivan Borozan , Limin Chen , Aled Edwards , Elizabeth Heathcote , Ian McGilvray
发明人: Ivan Borozan , Limin Chen , Aled Edwards , Elizabeth Heathcote , Ian McGilvray
CPC分类号: C12Q1/6809 , C12Q1/6883 , C12Q1/706 , G06F19/3456 , G16B20/00 , G16B25/00 , G16B30/00 , G16B40/00 , G16B50/00 , Y02A90/22 , Y02A90/26 , C12Q2565/201
摘要: Systems and methods are provided for predicting patient response to a therapy regimen for a liver disease or a disease that is treatable with an immunomodulatory disease therapy using gene expression classifiers. Systems and methods for screening for modulators of target gene expression are also provided. Systems and methods for developing therapeutics against one or more of the proteins coded for by genes of the present invention are also provided. Systems and methods for predicting a patient response to a regimen of pegylated interferon alpha and ribavirin in a therapy for hepatitis C viral infection are also provided.
摘要翻译: 提供了系统和方法,用于预测患者对用于使用基因表达分类器的免疫调节疾病治疗可治疗的肝病或疾病的治疗方案的反应。 还提供了用于筛选靶基因表达调节剂的系统和方法。 还提供了用于开发针对由本发明的基因编码的一种或多种蛋白质的治疗剂的系统和方法。 还提供了用于在丙型肝炎病毒感染的治疗中预测患者对聚乙二醇化干扰素α和利巴韦林方案的反应的系统和方法。