公开(公告)号：US20230110178A1

公开(公告)日：2023-04-13

申请号：US17810316

申请日：2022-06-30

Applicant: JANSSEN BIOTECH, INC.

Inventor： RHYS SALTER ,  VADIM DUDKIN ,  FENGBIN SONG ,  WEI ZHANG ,  SHALOM GOLDBERG ,  JOHN KEITH

IPC: A61K51/02 ,  A61K51/04 ,  A61K51/10

Abstract: Macrocyclic chelators for chelation of alpha-emitting radiometal ions, such as actinium-225 are provided. Also provided are radiometal complexes containing an alpha-emitting radiometal ion bound to the macrocyclic chelator via coordinate bonding, and radioimmunoconjugates containing the radiometal complexes covalently linked to a targeting ligand, such as an antibody or antigen binding fragment thereof. The radioimmunoconjugates can be produced by click chemistry reactions. Methods of using the radiocomplexes and radioimmunoconjugates for selectively targeting neoplastic cells for radiotherapy and for treating neoplastic diseases and disorders are also described.