公开(公告)号：US20240360421A1

公开(公告)日：2024-10-31

申请号：US18630620

申请日：2024-04-09

申请人： JANSSEN BIOTECH, INC.

发明人： Iqbal S GREWAL ,  Rajkumar GANESAN ,  Sanjaya SINGH

IPC分类号： C12N5/074 ,  A61K35/545 ,  C12N15/86

CPC分类号： C12N5/0696 ,  A61K35/545 ,  C12N15/86 ,  C12N2501/2315 ,  C12N2501/999 ,  C12N2502/1114

摘要： Provided here in are methods of producing induced pluripotent stem cells (iPSCs) and isolated population of produced induced pluripotent stem cells (iPSCs). Also provided herein are methods of treating a subject in need thereof using the produced iPSCs or pharmaceutical compositions comprising the produced iPSCs.

公开(公告)号：US12129310B2

公开(公告)日：2024-10-29

申请号：US18122948

申请日：2023-03-17

申请人： Janssen Biotech, Inc.

发明人： Sanjaya Singh ,  Rajkumar Ganesan ,  Jun Chen ,  Iqbal S. Grewal

IPC分类号： C07K16/42 ,  G01N33/68

CPC分类号： C07K16/42 ,  G01N33/6857 ,  C07K2317/14 ,  C07K2317/34

摘要： Molecules, including antibodies and antigen-binding fragments thereof that specifically bind to a linker peptide, and methods of producing and using the described antibodies and antigen-binding fragments are presented herein. Also presented herein methods of generating antibodies that specifically bind to an immunorecessive epitope.

公开(公告)号：US20240327869A1

公开(公告)日：2024-10-03

申请号：US18744565

申请日：2024-06-14

申请人： JANSSEN BIOTECH, INC.

发明人： William Lloyd PERRY, III ,  Brian TOMKOWICZ

IPC分类号： C12N15/86 ,  C12N7/00

CPC分类号： C12N15/86 ,  C12N7/00 ,  C12N2750/14121 ,  C12N2750/14151 ,  C12N2800/50 ,  C12N2830/36 ,  C12N2830/40 ,  C12N2830/42 ,  C12N2830/50

摘要： Recombinant constructs, cells and means for improved production of Adeno-Associated Viruses (AAVs) are described. Also described are methods of using the constructs and cells to produce recombinant AAVs.

公开(公告)号：US12098210B2

公开(公告)日：2024-09-24

申请号：US18052174

申请日：2022-11-02

申请人： JANSSEN BIOTECH, INC.

发明人： Jenna Goldberg ,  Jagoda Jasielec ,  Raluca Verona ,  Brendan Weiss

IPC分类号： C07K16/28 ,  A61K31/454 ,  A61K31/573 ,  A61K39/00 ,  A61K39/395 ,  A61P35/00 ,  C07K16/30

CPC分类号： C07K16/2878 ,  A61K31/454 ,  A61K31/573 ,  A61K39/3955 ,  A61K39/39558 ,  A61P35/00 ,  C07K16/2809 ,  C07K16/2896 ,  C07K16/30 ,  A61K2039/507 ,  A61K2039/545 ,  C07K2317/31

摘要： Disclosed are methods of treating cancers and enhancing efficacy of BCMAxCD3 bispecific antibodies. In particular, methods are disclosed of using a BCMAxCD3 bispecific antibody, an anti-CD38 antibody and/or pomalidomide to treat cancers, particularly relapsed or refractory multiple myeloma.

公开(公告)号：US20240294884A1

公开(公告)日：2024-09-05

申请号：US18663981

申请日：2024-05-14

申请人： Janssen Biotech, Inc.

发明人： Ricardo ATTAR ,  Jason DEHART ,  Selina KHAN ,  Vinod KRISHNA ,  Jenifer LUM ,  Christian MAINE ,  Barbara SANDERS ,  Manuel Alejandro SEPULVEDA ,  Patrick WILKINSON ,  Roland ZAHN

IPC分类号： C12N7/00 ,  A61K39/00 ,  A61K45/06 ,  C12N15/86

CPC分类号： C12N7/00 ,  A61K45/06 ,  C12N15/86 ,  A61K2039/505 ,  C12N2750/14111

摘要： Provided are vaccines, polypeptides and polynucleotides based on mutant CALR and JAK2 sequences, vectors, host cells, viruses, and methods of making and using them. The disclosure also provides methods of inducing an immune response and methods of treating, preventing, reducing a risk of onset or delaying the onset of a clinical condition characterized by an expression of JAK2V617F or CALR exon 9 mutant, or both JAK2V617F and CALR exon 9 mutant, wherein the method comprises a plurality of administrations of any of the compositions comprising polynucleotides, polypeptides or vectors disclosed herein.

公开(公告)号：US12076413B2

公开(公告)日：2024-09-03

申请号：US17512195

申请日：2021-10-27

申请人： JANSSEN BIOTECH, INC.

发明人： Rajkumar Ganesan ,  Iqbal S. Grewal ,  Sanjaya Singh ,  Michael Riis Hansen

IPC分类号： C07K16/28 ,  A61K47/68 ,  A61K39/00

CPC分类号： A61K47/6897 ,  C07K16/2809 ,  A61K39/00 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73

摘要： Provided herein, in certain aspects, are antibodies that bind to T cell receptor (TCR) Vγ9 (TRGV9), TCR Vδ2 (TRDV2), or the TCR gamma/delta constant region (TRGDC), as well as recombinant cells containing the vectors, and compositions comprising the antibodies. Methods of making and using the antibodies are also provided.

公开(公告)号：US12065488B2

公开(公告)日：2024-08-20

申请号：US17516082

申请日：2021-11-01

申请人： Janssen Biotech, Inc. ,  Applied Molecular Evolution, Inc.

发明人： Yan Chen ,  Debra Gardner ,  David M. Knight ,  Michael W. Lark ,  Bailin Liang ,  David M. Marquis ,  David J. Shealy ,  Eric Michael Smith ,  Xiao-yu R. Song ,  Vedrana Stojanovic-Susulic ,  Raymond Sweet ,  Susan Tam ,  Alain P. Vasserot ,  Sheng-Jiun Wu ,  Jing Yang

IPC分类号： C07K16/24 ,  A61K39/00

CPC分类号： C07K16/248 ,  A61K2039/505 ,  A61K2039/54 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

摘要： Anti-IL-6 antibodies and antirheumatics are useful to treat and suppress IL-6 related conditions, such as rheumatoid arthritis.

公开(公告)号：US20240226893A1

公开(公告)日：2024-07-11

申请号：US18559029

申请日：2022-05-12

申请人： IMEC VZW ,  Janssen Biotech Inc.

发明人： Peter Peumans ,  Olivier Henry ,  Willem Van Roy ,  Tim Stakenborg ,  Alexander Graham Irwin Tulloch

IPC分类号： B01L3/00

CPC分类号： B01L3/502761 ,  B01L3/502715 ,  B01L2200/0652 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/161 ,  B01L2400/086 ,  B01L2400/088

摘要： A device for sorting biological cells comprises a flow channel configured to pass a flow of liquid carrying the biological cells. The flow channel comprises at least one zone associated with a cell category. Each zone of the flow channel comprises at least one surface coated with molecules having an affinity to the cell category associated with the zone, the at least one surface of the zone being configured to modify, by the molecules of the surface, a movement of a cell belonging to the associated cell category of the zone as the cell passes the zone. The device comprises a detector configured to detect a cell exhibiting at least one modified movement in one zone of the flow channel, and to transmit a trigger signal based on the detection of the cell. The device further comprises an actuator configured to divert the detected cell based on the trigger signal.

公开(公告)号：US20240199748A1

公开(公告)日：2024-06-20

申请号：US18510412

申请日：2023-11-15

申请人： JANSSEN BIOTECH, INC.

发明人： Sylvie LAQUERRE ,  Matthew LORENZI ,  Sheri MOORES

IPC分类号： C07K16/28 ,  A61K31/5377 ,  A61K39/00 ,  A61K39/395 ,  A61P35/00

CPC分类号： C07K16/2863 ,  A61K31/5377 ,  A61K39/39558 ,  A61P35/00 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565

摘要： The present invention relates to combination therapies with bispecific anti-EGFR/c-Met antibodies and 3rd generation EGFR tyrosine kinase inhibitors.

公开(公告)号：US20240191215A1

公开(公告)日：2024-06-13

申请号：US18287742

申请日：2022-04-20

申请人： Janssen Biotech, Inc.

发明人： William Lloyd Perry, III

IPC分类号： C12N9/12 ,  C12Q1/48

CPC分类号： C12N9/1205 ,  C12Q1/48 ,  C12Y207/01095

摘要： Described herein are non-naturally occurring neomycin phosphotransferase (NPT) proteins and nucleic acid sequences encoding such NPT proteins. In a specific embodiment, the non-naturally occurring NPT proteins have reduced activity relative to wild-type NPT. The non-naturally occurring NPT proteins provided herein are useful as a selectable marker for screening transformed or transfected cells. Also provided herein are vectors and kits comprising a nucleic acid sequence encoding a non-naturally occurring NPT protein, and methods of producing cells expressing the non-naturally occurring NPT protein and a protein of interest or a non-coding RNA sequence of interest.