公开(公告)号：US20180325870A1

公开(公告)日：2018-11-15

申请号：US15616358

申请日：2017-06-07

申请人： JANSSEN PHARMACEUTICA NV

发明人： HENRY J. BRESLIN ,  CHAOZHONG CAI ,  WEI HE ,  ROBERT W. KAVASH

IPC分类号： A61K31/4164 ,  A61K9/28 ,  A61K9/20 ,  C07D275/06 ,  A61K31/4174 ,  C07D233/64

CPC分类号： A61K31/4164 ,  A61K9/20 ,  A61K9/2806 ,  A61K31/4174 ,  C07D233/64 ,  C07D275/06

摘要： The present invention is directed to novel opioid receptor modulators of Formula (I). The invention further relates to methods for preparing such compounds, pharmaceutical compositions containing them, and their use in the treatment of disorders that may be ameliorated or treated by the modulation of opioid receptors.