公开(公告)号：US20190023692A1

公开(公告)日：2019-01-24

申请号：US16140337

申请日：2018-09-24

申请人： JANSSEN SCIENCES IRELAND UC

发明人： Abdellah TAHRI ,  Tim Hugo Maria JONCKERS ,  Pierre Jean-Marie Bernard RABOISSON ,  Samuël Dominique DEMIN

IPC分类号： C07D403/06 ,  C07D519/00 ,  C07D417/14 ,  C07D471/04 ,  C07D403/14 ,  C07D401/14

摘要： Quinoxalinones and dihydroquinoxalinones having inhibitory activity on RSV replication and having the formula I including addition salts, and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.

公开(公告)号：US20160237083A1

公开(公告)日：2016-08-18

申请号：US15136769

申请日：2016-04-22

申请人： Janssen Sciences Ireland UC

发明人： Ludwig Paul COOYMANS ,  Samuël Dominique DEMIN ,  Lili HU ,  Tim Hugo Maria JONCKERS ,  Pierre Jean-Marie Bernard RABOISSON ,  Abdellah TAHRI ,  Sandrine Marie Helene VENDEVILLE

IPC分类号： C07D471/04 ,  C07D403/06 ,  C07D235/26 ,  C07D209/10 ,  C07D209/12

CPC分类号： C07D471/04 ,  C07D209/10 ,  C07D209/12 ,  C07D235/26 ,  C07D403/06

摘要： Indoles having inhibitory activity on RSV replication and having the formula I the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.

公开(公告)号：US20170044172A1

公开(公告)日：2017-02-16

申请号：US15303989

申请日：2015-04-13

申请人： Janssen Sciences Ireland UC

发明人： Lili HU ,  Samuël Dominique DEMIN ,  Sandrine Marie Helene VENDEVILLE ,  Abdellah TAHRI ,  Pierre Jean-Marie Bernard RABOISSON

IPC分类号： C07D487/10 ,  C07D471/20 ,  C07D519/00

CPC分类号： C07D487/10 ,  C07D471/20 ,  C07D519/00

摘要： The invention concerns novel substituted spiro urea azetidinyl or piperidinyl compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.

摘要翻译： 本发明涉及具有抗病毒活性的式（I）的新型取代的螺环脲氮杂环丁烷基或哌啶基化合物，特别是对呼吸道合胞病毒（RSV）的复制具有抑制活性。 本发明还涉及这种新型化合物的制备，包含这些化合物的组合物和用于治疗呼吸道合胞病毒感染的化合物。

公开(公告)号：US20160251377A1

公开(公告)日：2016-09-01

申请号：US15153591

申请日：2016-05-12

申请人： Janssen Sciences Ireland UC

发明人： Ludwig Paul Cooymans ,  Samuël Dominique DEMIN ,  Lili HU ,  Tim Hugo Maria JONCKERS ,  Pierre Jean-Marie Bernard RABOISSON ,  Abdellah TAHRI ,  Sandrine Marie Helene VENDEVILLE

IPC分类号： C07D519/00 ,  C07D471/04

CPC分类号： C07D519/00 ,  A61K31/437 ,  C07D471/04

摘要： Azaindoles having inhibitory activity on RSV replication and having the formula I compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.

公开(公告)号：US20160237096A1

公开(公告)日：2016-08-18

申请号：US15136773

申请日：2016-04-22

申请人： Janssen Sciences Ireland UC

发明人： Ludwig Paul COOYMANS ,  Samuël Dominique DEMIN ,  Lili HU ,  Tim Hugo Maria JONCKERS ,  Pierre Jean-Marie Bernard RABOISSON ,  Abdellah TAHRI ,  Sandrine Marie Helene VENDEVILLE

IPC分类号： C07D519/00 ,  C07F5/02 ,  C07D471/04

CPC分类号： C07D519/00 ,  C07D471/04 ,  C07F5/025

摘要： A compound satisfying formula I, a prodrug, N-oxide, addition salt, quaternary amine, metal complex, or a stereochemically isomeric form thereof; compositions contain these compounds as active ingredient and processes for preparing these compounds and compositions.

摘要翻译： 满足式I的化合物，前药，N-氧化物，加成盐，季胺，金属络合物或其立体化学异构形式; 组合物含有这些化合物作为活性成分和制备这些化合物和组合物的方法。