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![PIPERIDINE SUBSTITUTED TRICYCLIC PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES WITH INHIBITORY ACTIVITY ON THE REPLICATION OF THE RESPIRATORY SYNCYTIAL VIRUS (RSV)](/abs-image/US/2017/12/07/US20170349602A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170349602A1
公开(公告)日：2017-12-07
申请号：US15534458
申请日：2015-12-07
发明人： Abdellah TAHARI , Sandrine Marie Helene VENDEVILLE , Tim Hugo Maria JONCKERS , Pierre Jean-Marie Bernard RABOISSON , Samuël Dominique DEMIN , Lili HU
IPC分类号： C07D491/147 , C07D471/14 , C07D487/04 , C07D487/14
CPC分类号： C07D491/147 , A61K31/519 , A61K31/5377 , A61P31/14 , C07D401/04 , C07D401/14 , C07D471/14 , C07D487/04 , C07D487/14
摘要： The invention concerns novel substituted tricyclic pyrazolo pyrimidine compounds of formula (I-a) or (I-b) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use Sin the treatment of respiratory syncytial virus infection.
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公开(公告)号：US20170044172A1
公开(公告)日：2017-02-16
申请号：US15303989
申请日：2015-04-13
发明人： Lili HU , Samuël Dominique DEMIN , Sandrine Marie Helene VENDEVILLE , Abdellah TAHRI , Pierre Jean-Marie Bernard RABOISSON
IPC分类号： C07D487/10 , C07D471/20 , C07D519/00
CPC分类号： C07D487/10 , C07D471/20 , C07D519/00
摘要： The invention concerns novel substituted spiro urea azetidinyl or piperidinyl compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.
摘要翻译： 本发明涉及具有抗病毒活性的式（I）的新型取代的螺环脲氮杂环丁烷基或哌啶基化合物，特别是对呼吸道合胞病毒（RSV）的复制具有抑制活性。 本发明还涉及这种新型化合物的制备，包含这些化合物的组合物和用于治疗呼吸道合胞病毒感染的化合物。
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3.发明申请公开(公告)号：US20190023692A1
公开(公告)日：2019-01-24
申请号：US16140337
申请日：2018-09-24
发明人： Abdellah TAHRI , Tim Hugo Maria JONCKERS , Pierre Jean-Marie Bernard RABOISSON , Samuël Dominique DEMIN
IPC分类号： C07D403/06 , C07D519/00 , C07D417/14 , C07D471/04 , C07D403/14 , C07D401/14
摘要： Quinoxalinones and dihydroquinoxalinones having inhibitory activity on RSV replication and having the formula I including addition salts, and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
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4.发明申请CYCLIZED SULFAMOYLARYLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B 审中-公开循环磺酰氨酰胺衍生物及其作为治疗乙型肝炎的药物的用途公开(公告)号：US20170002025A1
公开(公告)日：2017-01-05
申请号：US15195809
申请日：2016-06-28
发明人： Sandrine Marie Helene VENDEVILLE , Stefaan Julien LAST , Samuël Dominique DEMIN , Sandrine Céline GROSSE , Geerwin Yvonne Paul HACHÉ , Lili HU , Serge Maria Aloysius PIETERS , Geert ROMBOUTS , Koen VANDYCK , Wim Gaston VERSCHUEREN , Pierre Jean-Marie Bernard RABOISSON
IPC分类号： C07D513/04 , A61K31/407 , C07D515/20 , A61K31/542 , C07D515/04 , C07D515/10 , A61K45/06 , A61K31/554
摘要： Inhibitors of HBV replication of Formula (I-A) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein Ra to Rd, and R1 to R8 have the meaning as defined herein.The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.
摘要翻译： 本发明还涉及制备所述化合物的方法，含有它们的药物组合物及其在HBV治疗中单独或与其它HBV抑制剂组合的用途。
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公开(公告)号：US20160237083A1
公开(公告)日：2016-08-18
申请号：US15136769
申请日：2016-04-22
发明人： Ludwig Paul COOYMANS , Samuël Dominique DEMIN , Lili HU , Tim Hugo Maria JONCKERS , Pierre Jean-Marie Bernard RABOISSON , Abdellah TAHRI , Sandrine Marie Helene VENDEVILLE
IPC分类号： C07D471/04 , C07D403/06 , C07D235/26 , C07D209/10 , C07D209/12
CPC分类号： C07D471/04 , C07D209/10 , C07D209/12 , C07D235/26 , C07D403/06
摘要： Indoles having inhibitory activity on RSV replication and having the formula I the prodrugs, N-oxides, addition salts, quaternary amines, metal complexes and stereochemically isomeric forms thereof; compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
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![PIPERIDINE SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES WITH INHIBITORY ACTIVITY ON THE REPLICATION OF THE RESPIRATORY SYNCYTIAL VIRUS (RSV)](/abs-image/US/2017/12/07/US20170349591A1/abs.jpg.150x150.jpg)
公开(公告)号：US20170349591A1
公开(公告)日：2017-12-07
申请号：US15534442
申请日：2015-12-07
发明人： Abdellah TAHARI , Sandrine Marie Helene VENDEVILLE , Tim Hugo Maria JONCKERS , Pierre Jean-Marie Bernard RABOISSON , Samuël Dominique DEMIN , Lili HU , Ludwig Paul COOYMANS
IPC分类号： C07D487/04
CPC分类号： C07D487/04 , A61P31/14
摘要： The invention concerns novel substituted bicyclic pyrazolo pyrimidine compounds of formula (I) having antiviral activity, in particular, having an inhibitory activity on the replication of the respiratory syncytial virus (RSV). The invention further concerns the preparation of such novel compounds, compositions comprising these compounds, and the compounds for use in the treatment of respiratory syncytial virus infection.
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公开(公告)号：US20160251377A1
公开(公告)日：2016-09-01
申请号：US15153591
申请日：2016-05-12
发明人： Ludwig Paul Cooymans , Samuël Dominique DEMIN , Lili HU , Tim Hugo Maria JONCKERS , Pierre Jean-Marie Bernard RABOISSON , Abdellah TAHRI , Sandrine Marie Helene VENDEVILLE
IPC分类号： C07D519/00 , C07D471/04
CPC分类号： C07D519/00 , A61K31/437 , C07D471/04
摘要： Azaindoles having inhibitory activity on RSV replication and having the formula I compositions containing these compounds as active ingredient and processes for preparing these compounds and compositions.
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8.发明申请AZABENZIMIDAZOLES AS RESPIRATORY SYNCYTIAL VIRUS ANTIVIRAL AGENTS 审中-公开作为呼吸道同源病毒抗病毒药物的AZABENZIMIDAZOLES公开(公告)号：US20160237096A1
公开(公告)日：2016-08-18
申请号：US15136773
申请日：2016-04-22
发明人： Ludwig Paul COOYMANS , Samuël Dominique DEMIN , Lili HU , Tim Hugo Maria JONCKERS , Pierre Jean-Marie Bernard RABOISSON , Abdellah TAHRI , Sandrine Marie Helene VENDEVILLE
IPC分类号： C07D519/00 , C07F5/02 , C07D471/04
CPC分类号： C07D519/00 , C07D471/04 , C07F5/025
摘要： A compound satisfying formula I, a prodrug, N-oxide, addition salt, quaternary amine, metal complex, or a stereochemically isomeric form thereof; compositions contain these compounds as active ingredient and processes for preparing these compounds and compositions.
摘要翻译： 满足式I的化合物，前药，N-氧化物，加成盐，季胺，金属络合物或其立体化学异构形式; 组合物含有这些化合物作为活性成分和制备这些化合物和组合物的方法。
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