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公开(公告)号：US10357454B2
公开(公告)日：2019-07-23
申请号：US15660746
申请日：2017-07-26
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Kazunori Kataoka , Akihiro Kishimura , Yasutaka Anraku , Kanjiro Miyata , Sayan Chuanoi , Tomoya Suma , Makoto Oba
Abstract: Provided is a method for easily and efficiently producing encapsulated substance vesicles wherein a substance is encapsulated in the cavity of vesicles obtained by polymer self-assembly. Empty vesicles that have membranes comprising a first polymer that is a block copolymer with uncharged hydrophilic segments and a first kind of charged segments and a second polymer with a second kind of charged segments that carry a charge that is the opposite of said first kind of charged segments as well as spaces that are enclosed by said membranes are mixed in an aqueous medium with the substance that is to be encapsulated in the spaces.
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公开(公告)号：US10471019B2
公开(公告)日：2019-11-12
申请号：US15683988
申请日：2017-08-23
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Kazunori Kataoka , Akihiro Kishimura , Yasutaka Anraku , Akinori Goto
Abstract: Provided is a monodisperse agglomerate of a substance-containing vesicle filled with a substance at a concentration higher than conventionally possible. A mixed solution, in which a target substance is included in an aqueous medium, is mixed with a monodisperse agglomerate of a crosslinked vesicle comprising a prescribed polymer which includes a first polymer, i.e. a block copolymer having uncharged hydrophilic segments and first charged segments, and a second polymer having second charged segments carrying a charge opposite to that of the first charged segments, and in which the first polymer and/or the second polymer are/is crosslinked. As a result, the crosslinked vesicle is made to contain the target substance.
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公开(公告)号：US09782358B2
公开(公告)日：2017-10-10
申请号：US14839854
申请日：2015-08-28
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Kazunori Kataoka , Akihiro Kishimura , Yasutaka Anraku , Akinori Goto
CPC classification number: A61K9/5146 , A61K9/10 , A61K9/5123 , B01J13/14 , C08G69/10 , C08G69/40 , C08L77/04
Abstract: Provided is a monodisperse agglomerate of a substance-containing vesicle filled with a substance at a concentration higher than conventionally possible. A mixed solution, in which a target substance is included in an aqueous medium, is mixed with a monodisperse agglomerate of a crosslinked vesicle comprising a prescribed polymer which includes a first polymer, i.e. a block copolymer having uncharged hydrophilic segments and first charged segments, and a second polymer having second charged segments carrying a charge opposite to that of the first charged segments, and in which the first polymer and/or the second polymer are/is crosslinked. As a result, the crosslinked vesicle is made to contain the target substance.
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Patent Agency Ranking
公开(公告)号：US20180015036A1
公开(公告)日：2018-01-18
申请号：US15660746
申请日：2017-07-26
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Kazunori Kataoka , Akihiro Kishimura , Yasutaka Anraku , Kanjiro Miyata , Sayan Chuanoi , Tomoya Suma , Makoto Oba
CPC classification number: A61K9/0087 , A61K9/1273 , B01J13/02 , B01J13/14
Abstract: Provided is a method for easily and efficiently producing encapsulated substance vesicles wherein a substance is encapsulated in the cavity of vesicles obtained by polymer self-assembly. Empty vesicles that have membranes comprising a first polymer that is a block copolymer with uncharged hydrophilic segments and a first kind of charged segments and a second polymer with a second kind of charged segments that carry a charge that is the opposite of said first kind of charged segments as well as spaces that are enclosed by said membranes are mixed in an aqueous medium with the substance that is to be encapsulated in the spaces.
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公开(公告)号：US20180008550A1
公开(公告)日：2018-01-11
申请号：US15684086
申请日：2017-08-23
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Kazunori Kataoka , Akihiro Kishimura , Yasutaka Anraku , Akinori Goto
CPC classification number: A61K9/5146 , A61K9/10 , A61K9/5123 , B01J13/14 , C08G69/10 , C08G69/40 , C08L77/04
Abstract: Provided is a monodisperse agglomerate of a substance-containing vesicle filled with a substance at a concentration higher than conventionally possible. A mixed solution, in which a target substance is included in an aqueous medium, is mixed with a monodisperse agglomerate of a crosslinked vesicle comprising a prescribed polymer which includes a first polymer, i.e. a block copolymer having uncharged hydrophilic segments and first charged segments, and a second polymer having second charged segments carrying a charge opposite to that of the first charged segments, and in which the first polymer and/or the second polymer are/is crosslinked. As a result, the crosslinked vesicle is made to contain the target substance.
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公开(公告)号：US10322092B2
公开(公告)日：2019-06-18
申请号：US15684086
申请日：2017-08-23
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Kazunori Kataoka , Akihiro Kishimura , Yasutaka Anraku , Akinori Goto
Abstract: Provided is a monodisperse agglomerate of a substance-containing vesicle filled with a substance at a concentration higher than conventionally possible. A mixed solution, in which a target substance is included in an aqueous medium, is mixed with a monodisperse agglomerate of a crosslinked vesicle comprising a prescribed polymer which includes a first polymer, i.e. a block copolymer having uncharged hydrophilic segments and first charged segments, and a second polymer having second charged segments carrying a charge opposite to that of the first charged segments, and in which the first polymer and/or the second polymer are/is crosslinked. As a result, the crosslinked vesicle is made to contain the target substance.
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公开(公告)号：US20180008549A1
公开(公告)日：2018-01-11
申请号：US15683988
申请日：2017-08-23
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Kazunori Kataoka , Akihiro Kishimura , Yasutaka Anraku , Akinori Goto
CPC classification number: A61K9/5146 , A61K9/10 , A61K9/5123 , B01J13/14 , C08G69/10 , C08G69/40 , C08L77/04
Abstract: Provided is a monodisperse agglomerate of a substance-containing vesicle filled with a substance at a concentration higher than conventionally possible. A mixed solution, in which a target substance is included in an aqueous medium, is mixed with a monodisperse agglomerate of a crosslinked vesicle comprising a prescribed polymer which includes a first polymer, i.e. a block copolymer having uncharged hydrophilic segments and first charged segments, and a second polymer having second charged segments carrying a charge opposite to that of the first charged segments, and in which the first polymer and/or the second polymer are/is crosslinked. As a result, the crosslinked vesicle is made to contain the target substance.
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公开(公告)号：US20160051484A1
公开(公告)日：2016-02-25
申请号：US14839854
申请日：2015-08-28
Applicant: JAPAN SCIENCE AND TECHNOLOGY AGENCY
Inventor： Kazunori Kataoka , Akihiro Kishimura , Yasutaka Anraku , Akinori Goto
CPC classification number: A61K9/5146 , A61K9/10 , A61K9/5123 , B01J13/14 , C08G69/10 , C08G69/40 , C08L77/04
Abstract: Provided is a monodisperse agglomerate of a substance-containing vesicle filled with a substance at a concentration higher than conventionally possible. A mixed solution, in which a target substance is included in an aqueous medium, is mixed with a monodisperse agglomerate of a crosslinked vesicle comprising a prescribed polymer which includes a first polymer, i.e. a block copolymer having uncharged hydrophilic segments and first charged segments, and a second polymer having second charged segments carrying a charge opposite to that of the first charged segments, and in which the first polymer and/or the second polymer are/is crosslinked. As a result, the crosslinked vesicle is made to contain the target substance.
Abstract translation: 提供了含有浓度高于常规可能的物质的含物质泡囊的单分散附聚物。 将含有目标物质的混合溶液与包含规定的聚合物的交联囊泡的单分散附聚物混合，该聚合物包括第一聚合物，即具有不带电亲水链段的嵌段共聚物和第一带电段，以及 第二聚合物，其具有带有与第一带电段的电荷相反的电荷的第二带电段，并且其中第一聚合物和/或第二聚合物被交联。 结果，使交联的囊泡含有目标物质。
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