公开(公告)号：US20110045587A1

公开(公告)日：2011-02-24

申请号：US12938294

申请日：2010-11-02

申请人： JOHN K. SULLIVAN ,  JOSEPH G. MCGIVERN ,  LESLIE P. MIRANDA ,  HUNG Q. NGUYEN ,  KENNETH W. WALKER ,  SHAW-FEN SYLVIA HU ,  COLIN V. GEGG ,  STEFAN I. MCDONOUGH

发明人： JOHN K. SULLIVAN ,  JOSEPH G. MCGIVERN ,  LESLIE P. MIRANDA ,  HUNG Q. NGUYEN ,  KENNETH W. WALKER ,  SHAW-FEN SYLVIA HU ,  COLIN V. GEGG ,  STEFAN I. MCDONOUGH

IPC分类号： C12N5/10 ,  C07H21/04 ,  C12N15/63 ,  C12N1/00 ,  C12N1/21

CPC分类号： A61K47/48215 ,  A61K38/00 ,  A61K47/60 ,  C07K14/43504 ,  C07K2319/30 ,  C07K2319/55

摘要： Disclosed is a DNA encoding a composition of matter of the formula (X1)a—(F1)d—(X2)b—(F2)e—(X3)c  (I) and multimers thereof, in which F1 and F2 are half-life extending moieties, and d and e are each independently 0 or 1, provided that at least one of d and e is 1; X1, X2, and X3 are each independently -(L)f-P-(L)g-, and f and g are each independently 0 or 1; P is a ShK peptide analog of no more than about 80 amino acid residues in length; L is an optional linker; and a, b, and c are each independently 0 or 1, provided that at least one of a, b and c is 1. A DNA encoding the ShK peptide analog is disclosed. Also disclosed are an expression vector comprising the DNA, and a host cell comprising the expression vector.

摘要翻译： 公开了编码式（X1）a-（F1）d-（X2）b-（F2）e-（X3）c（Ⅰ）及其多聚体的物质组成的DNA，其中F1和F2为一半 并且d和e各自独立地为0或1，条件是d和e中的至少一个为1; X1，X2和X3各自独立地为 - （L）f-P-（L）g-，f和g各自独立地为0或1; P是长度不超过约80个氨基酸残基的ShK肽类似物; L是可选的接头; 和a，b和c各自独立地为0或1，条件是a，b和c中的至少一个为1.编码ShK肽类似物的DNA。 还公开了包含DNA的表达载体和包含表达载体的宿主细胞。