公开(公告)号：US11453717B2

公开(公告)日：2022-09-27

申请号：US16097562

申请日：2016-12-02

Applicant: JOINT STOCK COMPANY “BIOCAD”

Inventor： Dmitry Valentinovich Morozov ,  Andrei Borisovich Ulitin ,  Ekaterina Sergeevna Zubareva ,  Iakov Iurevich Ustiugov ,  Aleksandr Vladimirovich Karabelskii ,  Dmitry Valeryevich Korzhavin ,  Tatiana Veniaminovna Chernovskaya ,  Aleksandr Valerevich Grachev ,  Yury Ivanovich Basovskiy ,  Ekaterina Aleksandrovna Lomkova ,  Veronika Sergeevna Usatova ,  Aleksei Aleksandrovich Aleksandrov ,  Elena Leonidovna Morozova ,  Roman Alekseevich Ivanov ,  Pavel Andreevich Iakovlev

IPC: C07K16/24 ,  A61K39/395 ,  A61P19/02 ,  A61K45/06 ,  A61K39/00

Abstract: The present invention relates to the field of biotechnology and provides monoclonal tri-specific binding molecules that specifically bind to human IL-17A, human IL-17F, and a human pro-inflammatory molecule (in particular, TNFα) with high affinity. The invention also relates to DNA constructs encoding said binding molecules, related expression vectors and methods of production, and methods of treatment using said binding molecules.