公开(公告)号：US5693341A

公开(公告)日：1997-12-02

申请号：US405320

申请日：1995-03-16

申请人： Jacqueline A. Schroeder ,  Hanne Bentz ,  Trudy D. Estridge

发明人： Jacqueline A. Schroeder ,  Hanne Bentz ,  Trudy D. Estridge

IPC分类号： A61K47/42 ,  A61K47/48 ,  A61K47/36 ,  A61K97/42

CPC分类号： A61K47/48292 ,  Y10S514/801

摘要： Affinity bound collagen matrices for the delivery of biologically active agents, and methods for preparing such matrices, are disclosed. A preferred method for preparing the matrices of the invention comprises mixing a binding ligand and an active agent together, allowing the resulting binding ligand-active agent mixture to form an affinity bound complex, then combining the resulting affinity bound complex with collagen to form a matrix. Particular affinity bound matrices comprising collagen, heparin, and an active agent are also disclosed, as well as methods for using the matrices of the invention for delivery of biologically active agents.

摘要翻译： 公开了用于递送生物活性剂的亲和结合胶原基质和制备这种基质的方法。 用于制备本发明的基质的优选方法包括将结合配体和活性剂混合在一起，使所得的结合配体 - 活性剂混合物形成亲和结合的复合物，然后将所得的亲和结合复合物与胶原组合以形成基质 。 还公开了包含胶原，肝素和活性剂的特定的亲和力结合基质，以及使用本发明的基质递送生物活性剂的方法。