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公开(公告)号：US08673945B2
公开(公告)日：2014-03-18
申请号：US13140348
申请日：2009-12-28
申请人： Jong Soo Woo , Jae Hyun Park , Young Il Kim , Kyeong Soo Kim , Ho Taek Yim , Ji Hyun Im
发明人： Jong Soo Woo , Jae Hyun Park , Young Il Kim , Kyeong Soo Kim , Ho Taek Yim , Ji Hyun Im
CPC分类号： A61K31/41 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/5084 , A61K31/4178 , A61K31/44 , A61K31/4422 , A61K2300/00
摘要： The present invention relates to a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising amlodipine and losartan as active ingredients, and a disintegrant which is a mixture of at least two components selected from the group consisting of sodium starch glycolate, crosscarmellose sodium, and crosspovidone, which exhibits a high and stable level of amlodipine and losartan dissolution rates.
摘要翻译： 本发明涉及一种用于预防或治疗包含氨氯地平和氯沙坦作为活性成分的心血管疾病的固体药物组合物，和崩解剂，其是选自淀粉羟乙酸钠，交联羧甲基纤维素钠和交联聚维酮的至少两种组分的混合物 ，其表现出高且稳定的氨氯地平和氯沙坦溶出速率水平。
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2.发明申请SOLID PHARMACEUTICAL COMPOSITION COMPRISING AMLODIPINE AND LOSARTAN WITH IMPROVED STABILITY 有权包含具有改善稳定性的阿片和洛沙坦的固体药物组合物公开(公告)号：US20110245301A1
公开(公告)日：2011-10-06
申请号：US13139426
申请日：2009-06-05
申请人： Jae Hyun Park , Kyeong Soo Kim , Ho Taek Yim , Ji Hyun Im
发明人： Jae Hyun Park , Kyeong Soo Kim , Ho Taek Yim , Ji Hyun Im
CPC分类号： A61K31/41 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/5084 , A61K31/4178 , A61K31/44 , A61K31/4422 , A61K2300/00
摘要： The present invention relates to a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising granular forms of amlodipine and losartan which are separated from each other, and a stabilizing agent, which has improved storage stability due to minimized interaction between amlodipine and losartan.
摘要翻译： 本发明涉及用于预防或治疗心血管疾病的固体药物组合物，其包含彼此分离的氨氯地平和氯沙坦的颗粒形式，以及由于氨氯地平与氯沙坦之间的相互作用最小化而具有改善的储存稳定性的稳定剂。
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3.发明授权Solid pharmaceutical composition comprising amlodipine and losartan with improved stability 有权固体药物组合物包含具有改善的稳定性的氨氯地平和氯沙坦公开(公告)号：US08673944B2
公开(公告)日：2014-03-18
申请号：US13139426
申请日：2009-06-05
申请人： Jae Hyun Park , Kyeong Soo Kim , Ho Taek Yim , Ji Hyun Im
发明人： Jae Hyun Park , Kyeong Soo Kim , Ho Taek Yim , Ji Hyun Im
CPC分类号： A61K31/41 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/5084 , A61K31/4178 , A61K31/44 , A61K31/4422 , A61K2300/00
摘要： The present invention relates to a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising granular forms of amlodipine and losartan which are separated from each other, and a stabilizing agent, which has improved storage stability due to minimized interaction between amlodipine and losartan.
摘要翻译： 本发明涉及用于预防或治疗心血管疾病的固体药物组合物，其包含彼此分离的氨氯地平和氯沙坦的颗粒形式，以及由于氨氯地平与氯沙坦之间的相互作用最小化而具有改善的储存稳定性的稳定剂。
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4.发明申请SOLID PHARMACEUTICAL COMPOSITION COMPRISING AMLODIPINE AND LOSARTAN 有权包含AMLODIPINE和LOSARTAN的固体药物组合物公开(公告)号：US20110251245A1
公开(公告)日：2011-10-13
申请号：US13140348
申请日：2009-12-28
申请人： Jong Soo Woo , Jae Hyun Park , Yong II Kim , Kyeong Soo Kim , Ho Taek Yim , Ji Hyun Im
发明人： Jong Soo Woo , Jae Hyun Park , Yong II Kim , Kyeong Soo Kim , Ho Taek Yim , Ji Hyun Im
IPC分类号： A61K31/4422 , A61P9/10 , A61P9/04 , A61P9/00 , A61P9/12
CPC分类号： A61K31/41 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/5084 , A61K31/4178 , A61K31/44 , A61K31/4422 , A61K2300/00
摘要： The present invention relates to a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising amlodipine and losartan as active ingredients, and a disintegrant which is a mixture of at least two components selected from the group consisting of sodium starch glycolate, crosscarmellose sodium, and crosspovidone, which exhibits a high and stable level of amlodipine and losartan dissolution rates.
摘要翻译： 本发明涉及一种用于预防或治疗包含氨氯地平和氯沙坦作为活性成分的心血管疾病的固体药物组合物，和崩解剂，其是选自淀粉羟乙酸钠，交联羧甲基纤维素钠和交联聚维酮的至少两种组分的混合物 ，其表现出高且稳定的氨氯地平和氯沙坦溶出速率水平。
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