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公开(公告)号：US08673945B2
公开(公告)日：2014-03-18
申请号：US13140348
申请日：2009-12-28
申请人： Jong Soo Woo , Jae Hyun Park , Young Il Kim , Kyeong Soo Kim , Ho Taek Yim , Ji Hyun Im
发明人： Jong Soo Woo , Jae Hyun Park , Young Il Kim , Kyeong Soo Kim , Ho Taek Yim , Ji Hyun Im
CPC分类号： A61K31/41 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/5084 , A61K31/4178 , A61K31/44 , A61K31/4422 , A61K2300/00
摘要： The present invention relates to a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising amlodipine and losartan as active ingredients, and a disintegrant which is a mixture of at least two components selected from the group consisting of sodium starch glycolate, crosscarmellose sodium, and crosspovidone, which exhibits a high and stable level of amlodipine and losartan dissolution rates.
摘要翻译： 本发明涉及一种用于预防或治疗包含氨氯地平和氯沙坦作为活性成分的心血管疾病的固体药物组合物，和崩解剂，其是选自淀粉羟乙酸钠，交联羧甲基纤维素钠和交联聚维酮的至少两种组分的混合物 ，其表现出高且稳定的氨氯地平和氯沙坦溶出速率水平。
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2.发明申请SOLID PHARMACEUTICAL COMPOSITION COMPRISING AMLODIPINE AND LOSARTAN 有权包含AMLODIPINE和LOSARTAN的固体药物组合物公开(公告)号：US20110251245A1
公开(公告)日：2011-10-13
申请号：US13140348
申请日：2009-12-28
申请人： Jong Soo Woo , Jae Hyun Park , Yong II Kim , Kyeong Soo Kim , Ho Taek Yim , Ji Hyun Im
发明人： Jong Soo Woo , Jae Hyun Park , Yong II Kim , Kyeong Soo Kim , Ho Taek Yim , Ji Hyun Im
IPC分类号： A61K31/4422 , A61P9/10 , A61P9/04 , A61P9/00 , A61P9/12
CPC分类号： A61K31/41 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/5084 , A61K31/4178 , A61K31/44 , A61K31/4422 , A61K2300/00
摘要： The present invention relates to a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising amlodipine and losartan as active ingredients, and a disintegrant which is a mixture of at least two components selected from the group consisting of sodium starch glycolate, crosscarmellose sodium, and crosspovidone, which exhibits a high and stable level of amlodipine and losartan dissolution rates.
摘要翻译： 本发明涉及一种用于预防或治疗包含氨氯地平和氯沙坦作为活性成分的心血管疾病的固体药物组合物，和崩解剂，其是选自淀粉羟乙酸钠，交联羧甲基纤维素钠和交联聚维酮的至少两种组分的混合物 ，其表现出高且稳定的氨氯地平和氯沙坦溶出速率水平。
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3.发明申请SOLID PHARMACEUTICAL COMPOSITION COMPRISING AMLODIPINE AND LOSARTAN WITH IMPROVED STABILITY 有权包含具有改善稳定性的阿片和洛沙坦的固体药物组合物公开(公告)号：US20110245301A1
公开(公告)日：2011-10-06
申请号：US13139426
申请日：2009-06-05
申请人： Jae Hyun Park , Kyeong Soo Kim , Ho Taek Yim , Ji Hyun Im
发明人： Jae Hyun Park , Kyeong Soo Kim , Ho Taek Yim , Ji Hyun Im
CPC分类号： A61K31/41 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/5084 , A61K31/4178 , A61K31/44 , A61K31/4422 , A61K2300/00
摘要： The present invention relates to a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising granular forms of amlodipine and losartan which are separated from each other, and a stabilizing agent, which has improved storage stability due to minimized interaction between amlodipine and losartan.
摘要翻译： 本发明涉及用于预防或治疗心血管疾病的固体药物组合物，其包含彼此分离的氨氯地平和氯沙坦的颗粒形式，以及由于氨氯地平与氯沙坦之间的相互作用最小化而具有改善的储存稳定性的稳定剂。
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4.发明授权Solid pharmaceutical composition comprising amlodipine and losartan with improved stability 有权固体药物组合物包含具有改善的稳定性的氨氯地平和氯沙坦公开(公告)号：US08673944B2
公开(公告)日：2014-03-18
申请号：US13139426
申请日：2009-06-05
申请人： Jae Hyun Park , Kyeong Soo Kim , Ho Taek Yim , Ji Hyun Im
发明人： Jae Hyun Park , Kyeong Soo Kim , Ho Taek Yim , Ji Hyun Im
CPC分类号： A61K31/41 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/5084 , A61K31/4178 , A61K31/44 , A61K31/4422 , A61K2300/00
摘要： The present invention relates to a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising granular forms of amlodipine and losartan which are separated from each other, and a stabilizing agent, which has improved storage stability due to minimized interaction between amlodipine and losartan.
摘要翻译： 本发明涉及用于预防或治疗心血管疾病的固体药物组合物，其包含彼此分离的氨氯地平和氯沙坦的颗粒形式，以及由于氨氯地平与氯沙坦之间的相互作用最小化而具有改善的储存稳定性的稳定剂。
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5.发明授权公开(公告)号：US08127516B2
公开(公告)日：2012-03-06
申请号：US12654572
申请日：2009-12-23
申请人： Chang Hyun Lee , Jong Soo Woo , Hong Gi Yi , Kyeong Soo Kim , Ho Taek Yim
发明人： Chang Hyun Lee , Jong Soo Woo , Hong Gi Yi , Kyeong Soo Kim , Ho Taek Yim
IPC分类号： B65B63/08
CPC分类号： A61K9/0056 , A61J3/10 , A61K9/2095 , B30B11/02 , B30B11/08 , B65B9/042 , B65B9/045
摘要： A method and packaging machine for preparing rapidly disintegrating formulations for oral administration are disclosed. The present invention is characterized in that a powdery mixture including a pharmaceutically active ingredient and a sugar or a sugar alcohol powder is filled into a packaging material and, thereafter, the mixture, filled in the packaging material, is heated. The present invention can simply and economically prepare an oral formulation which undergoes rapid disintegration in the oral cavity and provides for high-quality administration to patients.
摘要翻译： 公开了用于制备用于口服给药的快速崩解制剂的方法和包装机。 本发明的特征在于将包含药物活性成分和糖或糖醇粉末的粉末混合物填充到包装材料中，然后将填充在包装材料中的混合物加热。 本发明可以简单且经济地制备在口腔中快速崩解并提供给患者高质量给药的口服制剂。
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6.发明申请METHOD FOR PREPARING RAPIDLY DISINTEGRATING FORMULATION FOR ORAL ADMINISTRATION 审中-公开制备口服药物快速消毒配方的方法公开(公告)号：US20120110957A1
公开(公告)日：2012-05-10
申请号：US13343879
申请日：2012-01-05
申请人： Chang Hyun LEE , Jong Soo Woo , Hong Gi Yi , Kyeong Soo Kim , Ho Taek Yim
发明人： Chang Hyun LEE , Jong Soo Woo , Hong Gi Yi , Kyeong Soo Kim , Ho Taek Yim
IPC分类号： B65B63/08
CPC分类号： A61K9/0056 , A61J3/10 , A61K9/2095 , B30B11/02 , B30B11/08 , B65B9/042 , B65B9/045
摘要： A method and packaging machine for preparing rapidly disintegrating formulations for oral administration are disclosed. The present invention is characterized in that a powdery mixture including a pharmaceutically active ingredient and a sugar or a sugar alcohol powder is filled into a packaging material and, thereafter, the mixture, filled in the packaging material, is heated. The present invention can simply and economically prepare an oral formulation which undergoes rapid disintegration in the oral cavity and provides for high-quality administration to patients.
摘要翻译： 公开了用于制备用于口服给药的快速崩解制剂的方法和包装机。 本发明的特征在于将包含药物活性成分和糖或糖醇粉末的粉末混合物填充到包装材料中，然后将填充在包装材料中的混合物加热。 本发明可以简单且经济地制备在口腔中快速崩解并提供给患者高质量给药的口服制剂。
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7.发明申请公开(公告)号：US20100105783A1
公开(公告)日：2010-04-29
申请号：US12654572
申请日：2009-12-23
申请人： Chang Hyun Lee , Jong Soo Woo , Hong Gi Yi , Kyeong Soo Kim , Ho Taek Yim
发明人： Chang Hyun Lee , Jong Soo Woo , Hong Gi Yi , Kyeong Soo Kim , Ho Taek Yim
CPC分类号： A61K9/0056 , A61J3/10 , A61K9/2095 , B30B11/02 , B30B11/08 , B65B9/042 , B65B9/045
摘要： A method and packaging machine for preparing rapidly disintegrating formulations for oral administration are disclosed. The present invention is characterized in that a powdery mixture including a pharmaceutically active ingredient and a sugar or a sugar alcohol powder is filled into a packaging material and, thereafter, the mixture, filled in the packaging material, is heated. The present invention can simply and economically prepare an oral formulation which undergoes rapid disintegration in the oral cavity and provides for high-quality administration to patients.
摘要翻译： 公开了用于制备用于口服给药的快速崩解制剂的方法和包装机。 本发明的特征在于将包含药物活性成分和糖或糖醇粉末的粉末混合物填充到包装材料中，然后将填充在包装材料中的混合物加热。 本发明可以简单且经济地制备在口腔中快速崩解并提供给患者高质量给药的口服制剂。
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8.发明申请SOLID PHARMACEUTICAL COMPOSITION COMPRISING AMLODIPINE AND LOSARTAN AND PROCESS FOR PRODUCING SAME 有权包含AMLODIPINE和LOSARTAN的固体药物组合物及其生产方法公开(公告)号：US20110245302A1
公开(公告)日：2011-10-06
申请号：US13139673
申请日：2009-02-13
申请人： Jae Hyun Park , Kyeong Soo Kim , Ho Taek Yim
发明人： Jae Hyun Park , Kyeong Soo Kim , Ho Taek Yim
CPC分类号： A61K31/41 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/5084 , A61K31/4178 , A61K31/44 , A61K31/4422 , A61K2300/00
摘要： The present invention relates to a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising amlodipine or a pharmaceutically acceptable salt thereof and losartan or a pharmaceutically acceptable salt thereof, which exhibits high dissolution rates of amlodipine and losartan even under a low pH condition and improved storage stability.
摘要翻译： 本发明涉及用于预防或治疗心血管疾病的固体药物组合物，其包括氨氯地平或其药学上可接受的盐和氯沙坦或其药学上可接受的盐，其甚至在低pH条件下也显示出高的氨氯地平和氯沙坦溶解速率，并且改善了储存 稳定性。
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9.发明授权Solid pharmaceutical composition comprising amlodipine and losartan and process for producing same 有权包含氨氯地平和氯沙坦的固体药物组合物及其制备方法公开(公告)号：US09161933B2
公开(公告)日：2015-10-20
申请号：US13139673
申请日：2009-02-13
申请人： Jae Hyun Park , Kyeong Soo Kim , Ho Taek Yim
发明人： Jae Hyun Park , Kyeong Soo Kim , Ho Taek Yim
IPC分类号： A61K31/4422 , A61P9/00 , A61P9/10 , A61P9/12 , A61P9/04 , B29B9/16 , A61K31/41 , A61K9/20 , A61K31/4178 , A61K31/44
CPC分类号： A61K31/41 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/5084 , A61K31/4178 , A61K31/44 , A61K31/4422 , A61K2300/00
摘要： The present invention relates to a solid pharmaceutical composition for preventing or treating cardiovascular disorders comprising amlodipine or a pharmaceutically acceptable salt thereof and losartan or a pharmaceutically acceptable salt thereof, which exhibits high dissolution rates of amlodipine and losartan even under a low pH condition and improved storage stability.
摘要翻译： 本发明涉及用于预防或治疗心血管疾病的固体药物组合物，其包括氨氯地平或其药学上可接受的盐和氯沙坦或其药学上可接受的盐，其甚至在低pH条件下也显示出高的氨氯地平和氯沙坦溶解速率，并且改善了储存 稳定性。
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