公开(公告)号：US08193345B2

公开(公告)日：2012-06-05

申请号：US13051948

申请日：2011-03-18

申请人： Jae Jong Kim ,  Si Kyu Lim ,  Mi Ok Lee ,  Sang Myoun Lim ,  Bo-mi Lee ,  Dong Hwan Kim ,  Keum Soon Lee ,  Jeoung Hyun Ryu

发明人： Jae Jong Kim ,  Si Kyu Lim ,  Mi Ok Lee ,  Sang Myoun Lim ,  Bo-mi Lee ,  Dong Hwan Kim ,  Keum Soon Lee ,  Jeoung Hyun Ryu

IPC分类号： C07D498/16

CPC分类号： C07D498/18

摘要： The present invention relates to a method for separating and purifying a lactone compound with an unsaturated alkyl group from a lactone compound with a saturated alkyl group which is an analog thereof. More specifically, the present invention relates to a method for effectively separating a lactone compound with an unsaturated alkyl group such as FK506 at high purity by extraction with a silver ion (Ag+) solution without use of column chromatography.

摘要翻译： 本发明涉及从具有饱和烷基的内酯化合物（其类似物）分离和纯化具有不饱和烷基的内酯化合物的方法。 更具体地说，本发明涉及通过用银离子（Ag +）溶液萃取而不使用柱色谱法，以高纯度有效分离内酯化合物与不饱和烷基如FK506的方法。

公开(公告)号：US20110172413A1

公开(公告)日：2011-07-14

申请号：US13051948

申请日：2011-03-18

申请人： Jae Jong Kim ,  Si Kyu Lim ,  Mi Ok Lee ,  Sang Myoun Lim ,  Bo-mi Lee ,  Dong Hwan Kim ,  Keum Soon Lee ,  Jeoung Hyun Ryu

发明人： Jae Jong Kim ,  Si Kyu Lim ,  Mi Ok Lee ,  Sang Myoun Lim ,  Bo-mi Lee ,  Dong Hwan Kim ,  Keum Soon Lee ,  Jeoung Hyun Ryu

IPC分类号： C07D498/12 ,  C07D315/00

CPC分类号： C07D498/18

摘要： The present invention relates to a method for separating and purifying a lactone compound with an unsaturated alkyl group from a lactone compound with a saturated alkyl group which is an analog thereof. More specifically, the present invention relates to a method for effectively separating a lactone compound with an unsaturated alkyl group such as FK506 at high purity by extraction with a silver ion (Ag+) solution without use of column chromatography.

摘要翻译： 本发明涉及从具有饱和烷基的内酯化合物（其类似物）分离和纯化具有不饱和烷基的内酯化合物的方法。 更具体地说，本发明涉及通过用银离子（Ag +）溶液萃取而不使用柱色谱法，以高纯度有效分离内酯化合物与不饱和烷基如FK506的方法。

公开(公告)号：US20110183385A1

公开(公告)日：2011-07-28

申请号：US12672479

申请日：2008-05-06

申请人： Jae Jong Kim ,  Si Kyu Lim ,  Mi Ok Lee ,  Sang Myoun Lim ,  Bo-mi Lee ,  Dong Hwan Kim ,  Jeoung Hyun ,  Keum Soon Lee

发明人： Jae Jong Kim ,  Si Kyu Lim ,  Mi Ok Lee ,  Sang Myoun Lim ,  Bo-mi Lee ,  Dong Hwan Kim ,  Jeoung Hyun ,  Keum Soon Lee

IPC分类号： C12P17/18

CPC分类号： C12P17/18 ,  C12P17/188

摘要： The present invention relates to a method of fermenting and purifying tricyclo compounds, specifically FK506 and/or FK520, and more particularly, to a method of purifying tricyclo compounds by adding a hydrophobic absorbent resin as a carrier in culturing FK506 and/or FK520 producing bacteria.

摘要翻译： 本发明涉及三环化合物，特别是FK506和/或FK520发酵和纯化的方法，更具体地说，涉及一种通过在培养FK506和/或FK520产生细菌中添加疏水性吸收树脂作为载体来纯化三环化合物的方法 。

公开(公告)号：US20110275786A1

公开(公告)日：2011-11-10

申请号：US13144285

申请日：2009-11-26

申请人： Jin Suk Cho ,  Jong Won Yoon ,  Eun Soo Choi ,  Jeong Min Kim ,  Ho Joon Choi ,  Sung Hag Kim ,  Seong Kyu Kim ,  Jae Jong Kim

发明人： Jin Suk Cho ,  Jong Won Yoon ,  Eun Soo Choi ,  Jeong Min Kim ,  Ho Joon Choi ,  Sung Hag Kim ,  Seong Kyu Kim ,  Jae Jong Kim

IPC分类号： C07K9/00

CPC分类号： C12P19/60 ,  C07K9/008

摘要： Provided is a process for purifying a vancomycin wet body, comprising: dissolving a wet body obtained from a microorganism-fermented solution containing vancomycin into a water soluble solvent to a concentration of about 1 to 40 g/L and carrying out reverse osmosis filtration; and carrying out lyophilization of the filtered vancomycin. The process for purifying a vancomycin wet body provides high-purity vancomycin, while avoiding degradation of stability during a drying step.

摘要翻译： 本发明提供万古霉素湿体的净化方法，其特征在于，将从含有万古霉素的微生物发酵液得到的湿体溶解至约1〜40g / L的浓度，进行反渗透过滤; 并进行过滤的万古霉素的冻干。 净化万古霉素湿体的方法提供高纯度万古霉素，同时避免干燥步骤期间的稳定性降低。

公开(公告)号：US08609368B2

公开(公告)日：2013-12-17

申请号：US13144285

申请日：2009-11-26

申请人： Jin Suk Cho ,  Jong Won Yoon ,  Eun Soo Choi ,  Jeong Min Kim ,  Ho Joon Choi ,  Sung Hag Kim ,  Seong Kyu Kim ,  Jae Jong Kim

发明人： Jin Suk Cho ,  Jong Won Yoon ,  Eun Soo Choi ,  Jeong Min Kim ,  Ho Joon Choi ,  Sung Hag Kim ,  Seong Kyu Kim ,  Jae Jong Kim

IPC分类号： C12P1/00 ,  A61K38/14

CPC分类号： C12P19/60 ,  C07K9/008

摘要： Provided is a process for purifying a vancomycin wet body, comprising: dissolving a wet body obtained from a microorganism-fermented solution containing vancomycin into a water soluble solvent to a concentration of about 1 to 40 g/L and carrying out reverse osmosis filtration; and carrying out lyophilization of the filtered vancomycin. The process for purifying a vancomycin wet body provides high-purity vancomycin, while avoiding degradation of stability during a drying step.

摘要翻译： 本发明提供万古霉素湿体的净化方法，其特征在于，将从含有万古霉素的微生物发酵液得到的湿体溶解至约1〜40g / L的浓度，进行反渗透过滤; 并进行过滤的万古霉素的冻干。 净化万古霉素湿体的方法提供高纯度万古霉素，同时避免干燥步骤期间的稳定性降低。