公开(公告)号：US12075785B2

公开(公告)日：2024-09-03

申请号：US17834252

申请日：2022-06-07

申请人： Pro Farm Group, Inc.

发明人： Ratnakar N. Asolkar ,  Marja Koivunen ,  Pamela G. Marrone ,  Ana Lucia Cordova-Kreylos ,  Huazhang Huang

IPC分类号： A01N43/16 ,  A01N43/76 ,  A01N43/86 ,  A01N43/90 ,  A01N57/20 ,  A01N63/20 ,  C07D263/32 ,  C07D263/34 ,  C07D309/14 ,  C07D407/06 ,  C07D413/04 ,  C07D413/06 ,  C07D493/10 ,  C07D498/14 ,  C07D513/04 ,  C12N1/20 ,  C12P17/04 ,  C12P17/06 ,  C12P17/14 ,  C12P17/16 ,  C12P17/18 ,  A01N43/00 ,  C12N1/00 ,  C12R1/00 ,  C12R1/01

CPC分类号： A01N63/20 ,  A01N43/16 ,  A01N43/76 ,  A01N43/86 ,  A01N43/90 ,  A01N57/20 ,  C07D263/32 ,  C07D263/34 ,  C07D309/14 ,  C07D407/06 ,  C07D413/04 ,  C07D413/06 ,  C07D493/10 ,  C07D498/14 ,  C07D513/04 ,  C12N1/20 ,  C12N1/205 ,  C12P17/04 ,  C12P17/06 ,  C12P17/14 ,  C12P17/16 ,  C12P17/18 ,  A01N43/00 ,  C12N1/00 ,  C12R2001/00 ,  C12R2001/01 ,  A01N63/20 ,  A01N43/16 ,  A01N43/74 ,  A01N43/76 ,  A01N43/90

摘要： A species of Burkholderia sp with no known pathogenicity to vertebrates but with pesticidal activity (e.g., plants, insects, fungi, weeds and nematodes) is provided. Also provided are natural products derived from a culture of said species and methods of controlling pests using said natural products.

公开(公告)号：US11987590B2

公开(公告)日：2024-05-21

申请号：US17345570

申请日：2021-06-11

申请人： Revolution Medicines, Inc.

发明人： Gregory Lawrence Verdine ,  Brian Roger Bowman ,  Mathew Edward Sowa ,  Joshua Alan Van Dyke Blodgett ,  Keith Earl Robison ,  Dylan Talbot Stiles ,  Jay Paul Morgenstern ,  Sharon Ann Townson ,  Uddhav Kumar Shigdel

IPC分类号： A61K31/407 ,  A61K31/4353 ,  A61K31/436 ,  A61K47/62 ,  A61K47/64 ,  A61P35/00 ,  C07D491/18 ,  C07D498/18 ,  C12N9/90 ,  C12P17/18 ,  A61K38/00

CPC分类号： C07D491/18 ,  A61K31/407 ,  A61K31/4353 ,  A61K31/436 ,  A61K47/62 ,  A61K47/64 ,  A61P35/00 ,  C07D498/18 ,  C12N9/90 ,  C12P17/18 ,  C12Y502/01008 ,  A61K38/00

摘要： The invention features compounds (e.g., macrocyclic compounds) capable of modulating biological processes, for example through binding to a presenter protein (e.g., a member of the FKBP family, a member of the cyclophilin family, or PIN1) and a target protein such as CEP250. These compounds bind endogenous intracellular presenter proteins, such as the FKBPs or cyclophilins, and the resulting binary complexes selectively bind and modulate the activity of the target protein. Formation of a tripartite complex among the presenter protein, the compound, and the target protein is driven by both protein-compound and protein-protein interactions, and both are required for modulation of target protein activity.

公开(公告)号：US20190203238A1

公开(公告)日：2019-07-04

申请号：US15858040

申请日：2017-12-29

申请人： Industrial Technology Research Institute

发明人： Wen-Yin CHEN ,  Tsung-Lin YANG ,  Yung-Chi KUO

IPC分类号： C12P17/18

CPC分类号： C12P17/18

摘要： A method for producing galanthamine using a plant, includes (a) performing a thermal treatment on a living plant to induce accumulation of galanthamine therein, wherein the living plant is a plant belonging to the family Amaryllidaceae; and (b) placing the living plant in a medium and performing an electrical stimulation treatment on the living plant to release the galanthamine from the living plant to the medium.

公开(公告)号：US09862979B2

公开(公告)日：2018-01-09

申请号：US15182761

申请日：2016-06-15

申请人： Sun Pharmaceutical Industries (Australia) Pty Ltd

发明人： Thilo Winzer ,  Ian Alexander Graham ,  Tracy Carol Walker

IPC分类号： C12N15/00 ,  C12N9/04 ,  C12N9/10 ,  C12N5/04 ,  C12N5/00 ,  C12P19/34 ,  C12P21/06 ,  C12N1/20 ,  C12P17/18 ,  C12N15/82 ,  A01H5/00 ,  C07H21/04 ,  C07K14/415 ,  C12N15/52 ,  C12N9/02 ,  C12N9/18

CPC分类号： C12P17/18 ,  C07K14/415 ,  C12N9/0006 ,  C12N9/0071 ,  C12N9/1007 ,  C12N9/18 ,  C12N15/52 ,  C12N15/8243 ,  C12P17/188 ,  C12Y114/21001 ,  C12Y114/21002 ,  C12Y201/01117 ,  C12Y206/01052

摘要： The disclosure relates to a nucleic acid molecule isolated from a Papaver somniferum cultivar that produces the opiate alkaloid noscapine which comprises 10 genes involved in the biosynthesis of opiate alkaloids.

公开(公告)号：US20150056651A1

公开(公告)日：2015-02-26

申请号：US14246372

申请日：2014-04-07

申请人： OPX Biotechnologies, Inc.

发明人： Michael D. Lynch ,  Ryan T. Gill ,  Tanya E.W. Lipscomb

IPC分类号： C12P7/42 ,  C12P19/62 ,  C12P21/00 ,  C12P29/00

CPC分类号： C12P7/42 ,  C12N9/0008 ,  C12N9/0036 ,  C12N9/88 ,  C12N9/93 ,  C12P7/52 ,  C12P7/66 ,  C12P17/18 ,  C12P19/62 ,  C12P19/623 ,  C12P21/005 ,  C12P29/00 ,  C12Y604/01002

摘要： This invention relates to metabolically engineered microorganism strains, such as bacterial strains, in which there is an increased utilization of malonyl-CoA for production of a chemical product, which includes polyketides and 3-hydroxypropionic acid.

摘要翻译： 本发明涉及代谢工程化的微生物菌株，例如细菌菌株，其中丙二酰辅酶A用于生产化学产品的利用率增加，其中包括聚酮化合物和3-羟基丙酸。

公开(公告)号：US20140178354A1

公开(公告)日：2014-06-26

申请号：US14139692

申请日：2013-12-23

申请人： The Regents of the University of California

发明人： William Fenical ,  Paul Jensen ,  Tracy Mincer ,  Robert H.R. Feling

IPC分类号： A61K31/407 ,  A61K45/06 ,  C07D491/044

CPC分类号： A61K31/407 ,  A61K31/397 ,  A61K31/424 ,  A61K31/43 ,  A61K45/06 ,  C07D491/04 ,  C07D491/044 ,  C12P17/18 ,  C12P17/188

摘要： The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian cells. The CNB392 and CNB476 strains lie within the family Micromonosporaceae, and the generic epithet Salinospora has been proposed for this obligate marine group. The reaction products produced by this strain are classified as salinosporamides, and are particularly advantageous in treating neoplastic disorders due to their low molecular weight, low IC50 values, high pharmaceutical potency, and selectivity for cancer cells over fungi.

摘要翻译： 本发明基于以下发现：海洋放线菌株CNB392和CNB476的某些发酵产物是过度增殖哺乳动物细胞的有效抑制剂。 CNB392和CNB476菌株位于Micromonosporaceae中，并且为该专业海洋群体提出了通用表型Salinospora。 由该菌株产生的反应产物分类为salinosporamide，并且由于其低分子量，低​​IC 50值，高药物效力和对真菌的癌细胞的选择性而特别有利于治疗肿瘤性疾病。

公开(公告)号：US20110183385A1

公开(公告)日：2011-07-28

申请号：US12672479

申请日：2008-05-06

申请人： Jae Jong Kim ,  Si Kyu Lim ,  Mi Ok Lee ,  Sang Myoun Lim ,  Bo-mi Lee ,  Dong Hwan Kim ,  Jeoung Hyun ,  Keum Soon Lee

发明人： Jae Jong Kim ,  Si Kyu Lim ,  Mi Ok Lee ,  Sang Myoun Lim ,  Bo-mi Lee ,  Dong Hwan Kim ,  Jeoung Hyun ,  Keum Soon Lee

IPC分类号： C12P17/18

CPC分类号： C12P17/18 ,  C12P17/188

摘要： The present invention relates to a method of fermenting and purifying tricyclo compounds, specifically FK506 and/or FK520, and more particularly, to a method of purifying tricyclo compounds by adding a hydrophobic absorbent resin as a carrier in culturing FK506 and/or FK520 producing bacteria.

摘要翻译： 本发明涉及三环化合物，特别是FK506和/或FK520发酵和纯化的方法，更具体地说，涉及一种通过在培养FK506和/或FK520产生细菌中添加疏水性吸收树脂作为载体来纯化三环化合物的方法 。

公开(公告)号：US20070044681A1

公开(公告)日：2007-03-01

申请号：US11468382

申请日：2006-08-30

申请人： Naoko Tsuyoshi ,  Tomomi Kuwahara ,  Ryosuke Fudou ,  Toshimi Mizukoshi ,  Hiroo Yoshida

发明人： Naoko Tsuyoshi ,  Tomomi Kuwahara ,  Ryosuke Fudou ,  Toshimi Mizukoshi ,  Hiroo Yoshida

IPC分类号： C12P19/28 ,  C12N1/16 ,  C09D11/00

CPC分类号： C12P17/18 ,  C09D11/037 ,  C12P19/26

摘要： A compound denoted by general formula (1) below; wherein n denotes an integer from 0 to 8 and wherein each X denotes either a residue denoted by general formula (2) below or an amino group and at least one X is a residue denoted by general formula (2) below; and wherein R denotes C5H11 or C7H15 is provided.

摘要翻译： 由下述通式（1）表示的化合物; 其中n表示0至8的整数，并且其中每个X表示由下述通式（2）表示的残基或氨基，并且至少一个X为下述通式（2）表示的残基; 并且其中R表示C 5 H 11或C 7 H 15。

公开(公告)号：US07179834B2

公开(公告)日：2007-02-20

申请号：US10600854

申请日：2003-06-20

申请人： William Fenical ,  Paul Jensen ,  Tracy Mincer ,  Robert H. R. Feling

发明人： William Fenical ,  Paul Jensen ,  Tracy Mincer ,  Robert H. R. Feling

IPC分类号： A61K31/407 ,  C07D491/044

CPC分类号： A61K31/397 ,  A61K31/407 ,  A61K31/424 ,  A61K31/43 ,  C07D491/04 ,  C12P17/18

摘要： The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian cells. The CNB392 and CNB476 strains lie within the family Micromonosporaceae, and the generic epithet Salinospora has been proposed for this obligate marine group. The reaction products produced by this strain are classified as salinosporamides, and are particularly advantageous in treating neoplastic disorders due to their low molecular weight, low IC50 values, high pharmaceutical potency, and selectivity for cancer cells over fungi.

公开(公告)号：US07176233B2

公开(公告)日：2007-02-13

申请号：US11147622

申请日：2005-06-07

申请人： William Fenical ,  Paul Jensen ,  Tracy Mincer ,  Robert H. R. Feling

发明人： William Fenical ,  Paul Jensen ,  Tracy Mincer ,  Robert H. R. Feling

IPC分类号： A61K31/407 ,  A61P35/00 ,  C07D491/44

CPC分类号： A61K31/407 ,  A61K31/397 ,  A61K31/424 ,  A61K31/43 ,  A61K45/06 ,  C07D491/04 ,  C07D491/044 ,  C12P17/18 ,  C12P17/188

摘要： The present invention is based on the discovery that certain fermentation products of the marine actinomycete strains CNB392 and CNB476 are effective inhibitors of hyperproliferative mammalian cells. The CNB392 and CNB476 strains lie within the family Micromonosporaceae, and the generic epithet Salinospora has been proposed for this obligate marine group. The reaction products produced by this strain are classified as salinosporamides, and are particularly advantageous in treating neoplastic disorders due to their low molecular weight, low IC50 values, high pharmaceutical potency, and selectivity for cancer cells over fungi.

摘要翻译： 本发明基于以下发现：海洋放线菌株CNB392和CNB476的某些发酵产物是过度增殖哺乳动物细胞的有效抑制剂。 CNB392和CNB476菌株位于Micromonosporaceae中，并且为该专业海洋群体提出了通用表型Salinospora。 由该菌株产生的反应产物被归类为salinosporamide，并且由于其低分子量，低​​IC 50值，高药物效力和对真菌的癌细胞的选择性而特别有利于治疗肿瘤性疾病 。