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1.发明授权公开(公告)号：US08853264B2
公开(公告)日：2014-10-07
申请号：US12766255
申请日：2010-04-23
申请人： Jae-Kwan Hwang , Do-Un Kim , Jae-Youn Chung , Hee-Chul Chung , Kyu-Lee Han
发明人： Jae-Kwan Hwang , Do-Un Kim , Jae-Youn Chung , Hee-Chul Chung , Kyu-Lee Han
CPC分类号： A61K31/36 , A61K9/0095 , A61K9/2054 , A61K36/185 , Y02A50/401 , Y10S514/859 , Y10S514/886
摘要： The present invention relates to the use of lignan compounds for treating or preventing an inflammatory disease. More particularly, it relates to a method for preventing or treating an inflammatory disease, comprising administering to a subject in need thereof an effective amount of macelignan represented by Chemical Formula I or a pharmaceutically acceptable salt thereof. The lignan compound has the effect of inhibiting inflammatory reactions by inhibiting the production or expression of inflammation mediators NO, iNOS, PGE2, COX-2 and TNF-α and by treating or preventing inflammatory disease in vivo. Accordingly, the lignan compound or a Myristica fragrans extract will be highly useful for the treatment or prevention of an inflammatory disease.
摘要翻译： 本发明涉及木素素化合物用于治疗或预防炎性疾病的用途。 更具体地说，本发明涉及一种预防或治疗炎性疾病的方法，其包括向有需要的受试者施用有效量的由化学式I表示的肉豆蔻衣木脂或其药学上可接受的盐。 木酚素化合物具有通过抑制炎症介质NO，iNOS，PGE2，COX-2和TNF-α的产生或表达并通过在体内治疗或预防炎性疾病来抑制炎症反应的作用。 因此，木脂素化合物或肉豆蔻提取物对于治疗或预防炎性疾病是非常有用的。
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公开(公告)号：US20100285154A1
公开(公告)日：2010-11-11
申请号：US12766255
申请日：2010-04-23
申请人： Jae-Kwan Hwang , Do-Un Kim , Jae-Youn Chung , Hee-Chul Chung , Kyu-Lee Han
发明人： Jae-Kwan Hwang , Do-Un Kim , Jae-Youn Chung , Hee-Chul Chung , Kyu-Lee Han
CPC分类号： A61K31/36 , A61K9/0095 , A61K9/2054 , A61K36/185 , Y02A50/401 , Y10S514/859 , Y10S514/886
摘要： The present invention relates to the use of lignan compounds for treating or preventing an inflammatory disease. More particularly, it relates to a method for preventing or treating an inflammatory disease, comprising administering to a subject in need thereof an effective amount of macelignan represented by Chemical Formula I or a pharmaceutically acceptable salt thereof. The lignan compound has the effect of inhibiting inflammatory reactions by inhibiting the production or expression of inflammation mediators NO, iNOS, PGE2, COX-2 and TNF-α and by treating or preventing inflammatory disease in vivo. Accordingly, the lignan compound or a Myristica fragrans extract will be highly useful for the treatment or prevention of an inflammatory disease.
摘要翻译： 本发明涉及木素素化合物用于治疗或预防炎性疾病的用途。 更具体地说，本发明涉及一种预防或治疗炎性疾病的方法，其包括向有需要的受试者施用有效量的由化学式I表示的肉豆蔻衣木脂或其药学上可接受的盐。 木酚素化合物具有通过抑制炎症介质NO，iNOS，PGE2，COX-2和TNF-α的产生或表达并通过在体内治疗或预防炎性疾病来抑制炎症反应的作用。 因此，木脂素化合物或肉豆蔻提取物对于治疗或预防炎性疾病是非常有用的。
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3.发明申请公开(公告)号：US20080114058A1
公开(公告)日：2008-05-15
申请号：US11813590
申请日：2006-01-06
申请人： Jae-Kwan Hwang , Do-Un Kim , Jae-Youn Chung , Hee-Chul Chung , Kyu-Lee Han
发明人： Jae-Kwan Hwang , Do-Un Kim , Jae-Youn Chung , Hee-Chul Chung , Kyu-Lee Han
IPC分类号： A61K31/05 , A61K31/335
CPC分类号： A61K31/357 , Y02A50/40 , Y02A50/401
摘要： The present invention relates to the use of lignan compounds for treating or preventing an inflammatory disease. More particularly, it relates to a pharmaceutical composition for the treatment or prevention of an inflammatory disease, comprising a lignan compound represented by Formula I, as well as a treating method and the use of an inflammatory disease using the lignan compound. The lignan compound has the effect of inhibiting inflammatory reactions by inhibiting the production or expression of inflammation mediators NO, iNOS, PGE2, COX-2 and TNF-α. Accordingly, the lignan compound or a Myristica fragrans extract will be highly useful for the treatment or prevention of an inflammatory disease.
摘要翻译： 本发明涉及木素素化合物用于治疗或预防炎性疾病的用途。 更具体地说，本发明涉及用于治疗或预防炎性疾病的药物组合物，其包含式I所示的木酚素化合物，以及使用所述木酚素化合物的治疗方法和使用炎性疾病。 木酚素化合物具有通过抑制炎症介质NO，iNOS，PGE 2，COX-2和TNF-α的产生或表达来抑制炎症反应的作用。 因此，木脂素化合物或肉豆蔻提取物对于治疗或预防炎性疾病是非常有用的。
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公开(公告)号：US08642646B2
公开(公告)日：2014-02-04
申请号：US10585553
申请日：2005-01-07
申请人： Jae-Kwan Hwang , Jae-Youn Chung , Hee-Chul Chung , Kyung-Min Park
发明人： Jae-Kwan Hwang , Jae-Youn Chung , Hee-Chul Chung , Kyung-Min Park
CPC分类号： A61K31/085 , A61K31/05 , A61K31/352
摘要： The present invention relates to a method and composition for treating acne using lignan compounds represented by Formula 1. More particularly, the invention relates to an antibacterial composition against acne-causing bacteria, containing lignan compounds represented by Formula 1, as well as a method for treating acne using the same. The lignan compounds represented by Formula 1 are excellent not only in the antibacterial activity of inhibiting the growth of acne-causing bacteria, but also in thermal stability. Accordingly, the lignan compounds may be useful as antibacterial agents against the acne-causing bacteria, and acne treatment agents.
摘要翻译： 本发明涉及使用由式1表示的木酚素化合物治疗痤疮的方法和组合物。更具体地说，本发明涉及含有由式1表示的木酚素化合物的抗痤疮细菌的抗菌组合物，以及用于 使用相同的治疗痤疮。 由式1表示的木酚素化合物不仅具有抑制痤疮细菌生长的抗菌活性，而且在热稳定性方面优异。 因此，木脂素化合物可用作抗痤疮细菌和痤疮治疗剂的抗菌剂。
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公开(公告)号：US20090192217A1
公开(公告)日：2009-07-30
申请号：US10585553
申请日：2005-01-07
申请人： Jae-Kwan Hwang , Jae-Youn Chung , Hee-Chul Chung , Kyung-Min Park
发明人： Jae-Kwan Hwang , Jae-Youn Chung , Hee-Chul Chung , Kyung-Min Park
IPC分类号： A01N43/30 , C07D317/54 , A61P31/04
CPC分类号： A61K31/085 , A61K31/05 , A61K31/352
摘要： The present invention relates to a method and composition for treating acne using lignan compounds represented by Formula 1. More particularly, the invention relates to an antibacterial composition against acne-causing bacteria, containing lignan compounds represented by Formula 1, as well as a method for treating acne using the same. The lignan compounds represented by Formula 1 are excellent not only in the antibacterial activity of, inhibiting the growth of acne-causing bacteria, but also in thermal stability. Accordingly, the lignan compounds may be useful as antibacterial agents against the acne-causing bacteria, and acne treatment agents.
摘要翻译： 本发明涉及使用由式1表示的木酚素化合物治疗痤疮的方法和组合物。更具体地说，本发明涉及含有由式1表示的木酚素化合物的抗痤疮细菌的抗菌组合物，以及用于 使用相同的治疗痤疮。 由式1表示的木酚素化合物不仅具有抑制痤疮细菌生长的抗菌活性以及热稳定性的优异性。 因此，木脂素化合物可用作抗痤疮细菌和痤疮治疗剂的抗菌剂。
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