公开(公告)号：US07803837B2

公开(公告)日：2010-09-28

申请号：US11602551

申请日：2006-11-21

申请人： Jae-Kyu Jung ,  Graeme Semple ,  Benjamin R. Johnson

发明人： Jae-Kyu Jung ,  Graeme Semple ,  Benjamin R. Johnson

IPC分类号： A61K31/341 ,  A61K31/381 ,  C07D307/32 ,  C07D409/04

CPC分类号： C07D307/68 ,  C07D405/04 ,  C07D409/04 ,  C07D409/10

摘要： System for selecting a color shade comprising a very small number of color display cards with mixed shades of two or more colors. The system comprises means for selecting one shade among mixed shades, means for presenting the selected mixed shade as well as means for specifying the selected mixed shade for making paint in the desired color tone.

摘要翻译： 用于选择颜色的系统，其包括具有两种或更多种颜色的混合色调的非常少量的彩色显示卡。 该系统包括用于选择混合色调中的一个色调的装置，用于呈现所选择的混合色调的装置以及用于指定所选择的混合色调以用于制作所需色调的油漆的装置。

公开(公告)号：US08507473B2

公开(公告)日：2013-08-13

申请号：US13063305

申请日：2009-09-10

申请人： P. Douglas Boatman ,  Benjamin R. Johnson ,  Jae-Kyu Jung ,  Michelle Kasem ,  Thomas O. Schrader ,  Philip J. Skinner ,  Steven Colletti

发明人： P. Douglas Boatman ,  Benjamin R. Johnson ,  Jae-Kyu Jung ,  Michelle Kasem ,  Thomas O. Schrader ,  Philip J. Skinner ,  Steven Colletti

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/55 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10

CPC分类号： C07D471/04

摘要： The present invention is directed to certain 3H-imidazo[4,5-b]pyridin-5-ol derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the GPR81 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of GPR81 associated disorders, for example, dyslipidemia, atherosclerosis, atheromatous disease, hypertension, coronary heart disease, stroke, insulin resistance, impaired glucose tolerance, type 2 diabetes, syndrome X, obesity, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type 1 diabetes and acne.

摘要翻译： 本发明涉及式（Ia）的某些3H-咪唑并[4,5-b]吡啶-5-醇衍生物及其药学上可接受的盐，其表现出有用的药理学性质，例如GPR81受体的激动剂。 本发明还提供含有本发明化合物的药物组合物，以及使用本发明化合物和组合物治疗GPR81相关疾病例如血脂异常，动脉粥样硬化，动脉粥样硬化疾病，高血压，冠心病， 中风，胰岛素抵抗，葡萄糖耐量异常，2型糖尿病，X综合征，肥胖症，牛皮癣，类风湿性关节炎，克罗恩病，移植排斥反应，多发性硬化，系统性红斑狼疮，溃疡性结肠炎，1型糖尿病和痤疮。

公开(公告)号：US20110172209A1

公开(公告)日：2011-07-14

申请号：US13063305

申请日：2009-09-10

申请人： P. Douglas Boatman ,  Benjamin R. Johnson ,  Jae-Kyu Jung ,  Michelle Kasem ,  Thomas O. Schrader ,  Philip J. Skinner ,  Steven Colletti

发明人： P. Douglas Boatman ,  Benjamin R. Johnson ,  Jae-Kyu Jung ,  Michelle Kasem ,  Thomas O. Schrader ,  Philip J. Skinner ,  Steven Colletti

IPC分类号： A61K31/437 ,  C07D471/04 ,  A61K31/55 ,  A61P3/06 ,  A61P3/10 ,  A61P9/10 ,  A61P9/12 ,  A61P9/00 ,  A61P3/08 ,  A61P3/04 ,  A61P17/06 ,  A61P29/00 ,  A61P37/06 ,  A61P25/28 ,  A61P17/10

CPC分类号： C07D471/04

摘要： The present invention is directed to certain 3H-imidazo[4,5-b]pyridin-5-ol derivatives of Formula (Ia) and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists of the GPR81 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of GPR81 associated disorders, for example, dyslipidemia, atherosclerosis, atheromatous disease, hypertension, coronary heart disease, stroke, insulin resistance, impaired glucose tolerance, type 2 diabetes, syndrome X, obesity, psoriasis, rheumatoid arthritis, Crohn's disease, transplant rejection, multiple sclerosis, systemic lupus erythematosus, ulcerative colitis, type 1 diabetes and acne.

摘要翻译： 本发明涉及式（Ia）的某些3H-咪唑并[4,5-b]吡啶-5-醇衍生物及其药学上可接受的盐，其表现出有用的药理学性质，例如GPR81受体的激动剂。 本发明还提供含有本发明化合物的药物组合物，以及使用本发明化合物和组合物治疗GPR81相关疾病例如血脂异常，动脉粥样硬化，动脉粥样硬化疾病，高血压，冠心病， 中风，胰岛素抵抗，葡萄糖耐量异常，2型糖尿病，X综合征，肥胖症，牛皮癣，类风湿性关节炎，克罗恩病，移植排斥反应，多发性硬化，系统性红斑狼疮，溃疡性结肠炎，1型糖尿病和痤疮。

公开(公告)号：US09085581B2

公开(公告)日：2015-07-21

申请号：US13581846

申请日：2011-03-02

申请人： Robert M. Jones ,  Daniel J. Buzard ,  Tawfik Gharbaoui ,  Benjamin R. Johnson ,  Michelle Kasem ,  Thomas O. Schrader ,  Scott Stirn

发明人： Robert M. Jones ,  Daniel J. Buzard ,  Tawfik Gharbaoui ,  Benjamin R. Johnson ,  Michelle Kasem ,  Thomas O. Schrader ,  Scott Stirn

IPC分类号： C07D487/16 ,  A61K31/403 ,  C07D487/04

CPC分类号： C07D487/04

摘要： The present invention relates to salts, processes, and process intermediates useful in the preparation of (R)-2-(9-chloro -7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid of Formula (Ia), salts, and crystalline forms thereof. The compound (R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid has been identified as an S1P1 receptor modulator that is useful in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development, and atherosclerosis).

摘要翻译： 本发明涉及可用于制备（R）-2-（9-氯-7-（4-异丙氧基-3-（三氟甲基）苄氧基）-2,3-二氢-1H- - 吡咯并[1,2-a]吲哚-1-基）乙酸，其盐和结晶形式。 化合物（R）-2-（9-氯-7-（4-异丙氧基-3-（三氟甲基）苄氧基）-2,3-二氢-1H-吡咯并[1,2-a]吲哚-1-基） 乙酸被鉴定为可用于治疗S1P1受体相关疾病的S1P1受体调节剂，例如由淋巴细胞介导的疾病和病症，移植排斥反应，自身免疫性疾病和病症，炎性疾病和病症（例如急性和 慢性炎性病症），癌症和特征在于血管完整性的潜在缺陷或与血管发生相关的病症，例如可能是病理性的（例如，可能发生在炎症，肿瘤发展和动脉粥样硬化中）。

公开(公告)号：US20140010497A1

公开(公告)日：2014-01-09

申请号：US13994429

申请日：2012-08-22

申请人： David P. Kelly ,  Peter A. Ketteridge ,  Daniel J. Creeden ,  Benjamin R. Johnson

发明人： David P. Kelly ,  Peter A. Ketteridge ,  Daniel J. Creeden ,  Benjamin R. Johnson

IPC分类号： G02B6/26

CPC分类号： G02B6/268 ,  G02B6/14 ,  G02F1/383 ,  G02F2001/3528 ,  H01S3/06704 ,  H01S3/102 ,  H01S3/302

摘要： A broadband spectral power generator in a multimode optical fiber utilizes a standard multimode fiber that is coiled. A plate is placed on the coiled fiber and a force is applied to compresses the coiled fiber and thereby increase the interactions between the compressed windings and induce modal mixing and birefringence in the fiber. In addition, the compression causes additional non-linear processes to be excited and occur in the compressed fiber coil to generate more broadband light. This allows for better “mixing” of the spatial beam in the multimode fiber coil and allows for the various modes to overlap. The multimode fiber coil is made of silica, silicate, germinate, phosphate, fluoride, chalcogenide, or telluride. The compressed coiled fiber may be driven by a laser providing more than one wavelength output and this greatly increases the amount of nonlinear mixing in the fiber for a greatly enhanced spectral coverage.

摘要翻译： 多模光纤中的宽带光谱发生器利用卷绕的标准多模光纤。 将板放置在卷绕的纤维上并施加力以压缩卷绕的纤维，从而增加压缩绕组之间的相互作用，并引起纤维中的模态混合和双折射。 此外，压缩使得额外的非线性处理被激发并发生在压缩的光纤线圈中以产生更多的宽带光。 这允许在多模光纤线圈中更好地“混合”空间光束，并允许各种模式重叠。 多模纤维线圈由二氧化硅，硅酸盐，发芽体，磷酸盐，氟化物，硫族化物或碲化物制成。 压缩的盘绕的光纤可以由提供多于一个波长输出的激光器驱动，并且大大增加了光纤中的非线性混合量，从而大大增强了光谱覆盖。

公开(公告)号：US07019439B2

公开(公告)日：2006-03-28

申请号：US10208433

申请日：2002-07-30

申请人： Eugene A. DeCastro ,  Benjamin R. Johnson ,  Eugene Phaneuf ,  Timothy W. Piazza

发明人： Eugene A. DeCastro ,  Benjamin R. Johnson ,  Eugene Phaneuf ,  Timothy W. Piazza

IPC分类号： H01L41/00 ,  H01L41/04

CPC分类号： B06B1/0618

摘要： A transducer assembly for receiving a stimulating signal and producing ultrasound therefrom at one or more frequencies, over an ultrabroad bandwidth at each frequency, includes a front mass disposed about a central axis, and a back mass disposed about the central axis, laterally offset from the front mass. The transducer assembly also includes one or more resonators disposed about the central axis and between the front mass and the back mass, including at least one electrical contact for receiving the stimulating signal. The back mass consists of a low-density material, such as aluminum, aluminum alloy, magnesium, or magnesium alloy, or any of various low-density materials known in the art. In general, the back mass is characterized by a density of less than 6.0 g/cc. In one embodiment, the front mass and the back mass are made from different materials, and the front mass includes a deviation from symmetrical symmetry.

公开(公告)号：US09176278B2

公开(公告)日：2015-11-03

申请号：US13994429

申请日：2012-08-22

申请人： David P. Kelly ,  Peter A. Ketteridge ,  Daniel J. Creeden ,  Benjamin R. Johnson

发明人： David P. Kelly ,  Peter A. Ketteridge ,  Daniel J. Creeden ,  Benjamin R. Johnson

IPC分类号： G02B6/26 ,  G02B6/42 ,  H01S3/30 ,  G02F1/383 ,  H01S3/067 ,  H01S3/102 ,  G02B6/14 ,  G02F1/35

CPC分类号： G02B6/268 ,  G02B6/14 ,  G02F1/383 ,  G02F2001/3528 ,  H01S3/06704 ,  H01S3/102 ,  H01S3/302

摘要： A broadband spectral power generator in a multimode optical fiber utilizes a standard multimode fiber that is coiled. A plate is placed on the coiled fiber and a force is applied to compresses the coiled fiber and thereby increase the interactions between the compressed windings and induce modal mixing and birefringence in the fiber. In addition, the compression causes additional non-linear processes to be excited and occur in the compressed fiber coil to generate more broadband light. This allows for better “mixing” of the spatial beam in the multimode fiber coil and allows for the various modes to overlap. The multimode fiber coil is made of silica, silicate, germinate, phosphate, fluoride, chalcogenide, or telluride. The compressed coiled fiber may be driven by a laser providing more than one wavelength output and this greatly increases the amount of nonlinear mixing in the fiber for a greatly enhanced spectral coverage.

摘要翻译： 多模光纤中的宽带光谱发生器利用卷绕的标准多模光纤。 将板放置在卷绕的纤维上并施加力以压缩卷绕的纤维，从而增加压缩绕组之间的相互作用，并引起纤维中的模态混合和双折射。 此外，压缩使得额外的非线性处理被激发并发生在压缩的光纤线圈中以产生更多的宽带光。 这允许在多模光纤线圈中更好地“混合”空间光束，并允许各种模式重叠。 多模纤维线圈由二氧化硅，硅酸盐，发芽体，磷酸盐，氟化物，硫族化物或碲化物制成。 压缩的盘绕的光纤可以由提供多于一个波长输出的激光器驱动，并且大大增加了光纤中的非线性混合量，从而大大增强了光谱覆盖。

公开(公告)号：US20150309275A1

公开(公告)日：2015-10-29

申请号：US14649584

申请日：2014-10-02

申请人： Benjamin R. JOHNSON ,  David P. KELLY ,  Michael J. SHAW ,  BAE SYSTEMS INFORMATION AND ELECTRONIC SYSTEMS INTEGRATION INC.

发明人： Benjamin R. Johnson ,  David P. Kelly ,  Michael J. Shaw

IPC分类号： G02B6/44

CPC分类号： G02B6/4407 ,  G02B6/3814 ,  G02B6/4268 ,  G02B6/4296 ,  G02B6/4436 ,  G02B6/4477

摘要： A system and method for passing a fiber cable through a fiber connector is presented. A fiber connector includes an outer body and a series of flutes inside the outer body. The outer body forms an interior chamber that has a first opening and a second opening. The first opening allows a coolant to flow into the first opening and the first and second openings allow the fiber cable to pass through the first opening and the second opening and through the fiber connector. A series of flutes are attached to an inner surface of the outer body and extend into the interior chamber. The flutes are spaced apart from each other and extend from the inner surface toward the fiber cable but do not touch the fiber cable when no liquid is flowing in the fiber connector.

摘要翻译： 提出了一种使光纤通过光纤连接器的系统和方法。 光纤连接器包括外部主体和外部主体内的一系列凹槽。 外部主体形成具有第一开口和第二开口的内部室。 第一开口允许冷却剂流入第一开口，并且第一和第二开口允许光缆穿过第一开口和第二开口并穿过光纤连接器。 一系列凹槽连接到外体的内表面并延伸到内腔中。 凹槽彼此间隔开并从内表面向纤维缆线延伸，但是当光纤连接器中没有液体流动时，不会接触光缆。

公开(公告)号：US20120329848A1

公开(公告)日：2012-12-27

申请号：US13581846

申请日：2011-03-02

申请人： Robert M. Jones ,  Daniel J. Buzard ,  Tawfik Gharbaoui ,  Benjamin R. Johnson ,  Michelle Kasem ,  Thomas O. Schrader ,  Scott Stirn

发明人： Robert M. Jones ,  Daniel J. Buzard ,  Tawfik Gharbaoui ,  Benjamin R. Johnson ,  Michelle Kasem ,  Thomas O. Schrader ,  Scott Stirn

IPC分类号： C07D487/04 ,  C07C41/01 ,  A61P37/00 ,  A61P9/10 ,  A61P3/10 ,  A61P17/10 ,  A61P1/16 ,  A61P17/06 ,  A61K31/407 ,  A61P1/04

CPC分类号： C07D487/04

摘要： The present invention relates to salts, processes, and process intermediates useful in the preparation of (R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid of Formula (Ia), salts, and crystalline forms thereof. The compound (R)-2-(9-chloro-7-(4-isopropoxy-3-(trifluoromethyl)benzyloxy)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetic acid has been identified as an S1P1 receptor modulator that is useful in the treatment of S1P1 receptor-associated disorders, for example, diseases and disorders mediated by lymphocytes, transplant rejection, autoimmune diseases and disorders, inflammatory diseases and disorders (e.g., acute and chronic inflammatory conditions), cancer, and conditions eases characterized by an underlying defect in vascular integrity or that are associated with angiogenesis such as may be pathologic (e.g., as may occur in inflammation, tumor development, and atherosclerosis).

摘要翻译： 本发明涉及可用于制备（R）-2-（9-氯-7-（4-异丙氧基-3-（三氟甲基）苄氧基）-2,3-二氢-1H- - 吡咯并[1,2-a]吲哚-1-基）乙酸，其盐和结晶形式。 化合物（R）-2-（9-氯-7-（4-异丙氧基-3-（三氟甲基）苄氧基）-2,3-二氢-1H-吡咯并[1,2-a]吲哚-1-基） 乙酸被鉴定为可用于治疗S1P1受体相关疾病的S1P1受体调节剂，例如由淋巴细胞介导的疾病和病症，移植排斥反应，自身免疫性疾病和病症，炎性疾病和病症（例如急性和 慢性炎性病症），癌症和病症特征在于血管完整性的潜在缺陷或与血管发生相关的疾病，例如可能是病理性的（例如，可能发生在炎症，肿瘤发展和动脉粥样硬化中）。