公开(公告)号：US20070161695A1

公开(公告)日：2007-07-12

申请号：US11714352

申请日：2007-03-06

申请人： Jaime Bunda ,  Robert DeVita ,  Jinlong Jiang ,  Sander Mills

发明人： Jaime Bunda ,  Robert DeVita ,  Jinlong Jiang ,  Sander Mills

IPC分类号： A61K31/4035 ,  C07D209/44

CPC分类号： C07D209/44

摘要： The present invention is directed to certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

公开(公告)号：US20050165083A1

公开(公告)日：2005-07-28

申请号：US11043213

申请日：2005-01-26

申请人： Jaime Bunda ,  Robert DeVita ,  Jinlong Jiang ,  Sander Mills

发明人： Jaime Bunda ,  Robert DeVita ,  Jinlong Jiang ,  Sander Mills

IPC分类号： C07D209/44 ,  A61K31/4035

CPC分类号： C07D209/44

摘要： The present invention is directed to certain hydroisoindoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

摘要翻译： 本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂，速激肽抑制剂，特别是物质P的某些加氢异吲哚啉化合物。本发明还涉及包含这些化合物作为活性成分的药物制剂和 使用化合物及其制剂治疗某些疾病，包括呕吐，尿失禁，抑郁和焦虑。

公开(公告)号：US20080009518A1

公开(公告)日：2008-01-10

申请号：US11667851

申请日：2005-11-29

申请人： Jaime Bunda ,  Robert DeVita ,  Jinlong Jiang ,  Sander Mills

发明人： Jaime Bunda ,  Robert DeVita ,  Jinlong Jiang ,  Sander Mills

IPC分类号： A61K31/47 ,  A61P13/00 ,  A61P25/06 ,  A61P25/22 ,  A61P25/24 ,  A61P29/00 ,  C07D215/20 ,  C07D215/26 ,  C07D215/60

CPC分类号： C07D215/20 ,  C07D215/26 ,  C07D215/60 ,  C07D401/06

摘要： The present invention is directed to certain 5-phenyl-5,6,7,8-hydroquinoline compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.

摘要翻译： 本发明涉及可用作神经激肽-1（NK-1）受体拮抗剂的某些5-苯基-5,6,7,8-氢喹啉化合物，以及速激肽抑制剂，特别是物质P。本发明也是 涉及包含这些化合物作为活性成分的药物制剂，以及这些化合物及其制剂在治疗某些疾病（包括呕吐，尿失禁，抑郁和焦虑）中的用途。